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IJCRR - 6(8), April, 2014

Pages: 04-13

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COMPARATIVE STUDY OF DIFFERENT DOSES OF EPIDURAL BUTORPHANOL FOR POSTOPERATIVE ANALGESIA IN ORTHOPAEDIC PATIENTS

Author: Sanjeev B. Birajdar, Vaishali A. Gawande, Ramchandra G. Latti, Bhagyashri R. Latti

Category: Healthcare

Abstract:Introduction: Previously studied epidural narcotic agonist such as fentanyl and morphine are capable of producing post-operative analgesia with undesirable side effects such as pruritis, nausea and respiratory depression that have limited their use. The objective of our study was to compare the duration and quality of postoperative analgesia offered by two different doses of epidural butorphanol. Methods: Our study comprised of Group A and B of 30 patients each, receiving 1mg and 2mg of butorphanolrespectively, diluted upto 10ml of normal saline and given by epidural catheter. Results: The study was a prospective randomized double blind study.In bothgroups A and B, epidural butorphanol in doses of 1mg and 2mg, both provided good quality of postoperative analgesia as determined by the Visual Analogue Scale scores in the postoperative period. Conclusion: The duration of postoperative analgesia provided by 2mg of epidural butorphanol is slightly longer than that provided by 1mg, but the difference is statistically not significant

Keywords: Pain, Epidural Butorphanol, Postoperative analgesia, Orthopaedic, Visual Analog Scale (VAS) score, Hemodynamic effects, Sedation

Full Text:

INTRODUCTION

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage as defined by the International Association for Study of Pain. Surgical trauma causes severe tissue damage.Intraoperative and postoperative pain management should be an essential and integral part of the care given to the patient. Severity of postoperative pain varies with site of operation, age, sex, premedication employed, anaesthetic agent used, psychological makeup of the patient and quality of postoperative care given. Attenuation of postoperative pain, especially using certain type of analgesic regimens may decrease peri-operative morbidity and mortality. Anaesthesia administered for orthopaedic lower limb surgery is quite frequent and a routine practice for anesthesiologist.The importance of such intervention and effective pain control for ambulation of operated patients is essential. Epidural anaesthesia, has become a safe technique with advancement in procedures as well as in equipments (needle, catheter) etc. It is particularly preferred to administer intraspinal or epidural narcotic along with local anaesthetic. The addition of opioid to an epidurally administered local anaesthetic has been suggested to improve the quality of analgesia provided by a local anaesthetic like bupivacaine alone. A drug such as butorphanol a mu-agonist / antagonist and S / K agonist might be expected to be useful in the management of post-operative pain. Our aim was to study and compare the duration of postoperative analgesia offered by two different doses (1mg and 2mg) of epidurally administered butorphanol; to compare the hemodynamic changes and the incidence of side effects of two different doses of epidural butorphanol. And our objective was to compare the duration and quality of postoperative analgesia offered by two different doses of epidural butorphanol.

MATERIALS AND METHODS

The study was a prospective randomized double blind study conducted in orthopaedic operation theatre ofGrant Medical College, Mumbai. It comprised of 60 patients, aged 20- 70 years, of either sex and of ASA grade I and II posted for elective orthopaedic surgery of lower limb and hip. Patients were evaluated preoperatively. Detailed history was taken and the procedure of spinal/ epidural and visual analogue scale was explained to the patients. Thorough physical examination was carried out. Patients’ height and weight were recorded.All routine investigations such ashaemoglobin, complete blood count, blood sugar, kidney and liver function tests, coagulation profile, Echocardiography (ECG) and Chest X-ray were done. The study was approved by the Ethical committee anda written valid informed consent was taken from all the patients. Patients with ASA grade III, IV,V; those with age 70 years; those with co-existing systemic diseases like Hypertension, Asthma, Diabetes, Heart disease, renal and hepatic diseases, and psychiatric diseases; those undergoing surgery with operative time more than 3 hours; and uncooperative patients were excluded from the study. Baseline pulse rate, blood pressure, respiratory rate and oxygen saturation were recorded. Intravenous access with 18 gauge cannula was established.Preloading was done with Ringer lactate at the rate of 10 ml/ kg. Under all aseptic precautions epidural catheter was inserted through 16 G epidural needle at L3-L4 / L4 - L5 space and spinal anaesthesia was given with 3 ml of 0.5% heavy bupivacaine one space below (i.e. two level spinal – epidural) in sitting position.Patients were made to lie supine on the table. The sensory level by pin prick, Bromage scale and subjective pain score were recorded. Intraoperative pulse rate, blood pressure, respiratory rate and oxygen saturation were recorded for every 2minutes for first 10minutes and every 10 minutes for next 20minutes and there after every 30minutes. Also intravenous fluids, blood given were recorded. On completion of surgery duration of surgery were evaluated. Postoperatively the patients were observed in the recovery room. Patients complaining of discomfort or pain (Visual Analog Scale score of 1) were administered study drug. GROUP A: 30 Patients receiving 1mg of butorphanol diluted upto 10 ml of Normal saline and given by epidural catheter. GROUP B: 30 Patients receiving 2mg of butorphanol diluted upto 10 ml of normal saline given by epidural catheter for pain relief. The patients were observed in the recovery room and later in their respective wards for 8 hours with written instructions to withhold any analgesic or sedative. The patients were monitored for Pulse rate, Blood pressure (Systolic and Diastolic), Oxygen saturation (SpO2), Respiratory rate and Duration of analgesia. Patients were assessed for pain by 0 – 10 cm linear Visual Analogue Scale (VAS). It is a 10 cm long  scale of which 0 end is marked as no pain while other end as worst possible pain. The patients were asked to point out the intensity of pain as experienced by them on the scale. Duration of postoperative analgesia was calculated from the time of first dose of epidural Butorphanol to the time upto when patient again experienced pain (i.e. VAS score of 1). Rescue analgesia was given in the form of 75 mg of Diclofenac Sodium given intramuscularly whenever the patients experienced visual analogue pain score ≥ 4. The following parameters were noted in the postoperative period. 1. Pain score and duration of analgesia. 2. Vital parameters like pulse rate, systolic and diastolic blood pressure, respiratory rate and oxygen saturation. 3. Side effects like nausea, vomiting, pruritis, respiratory depression and urinary retention. Patients were also observed post operatively for sedation caused by epidural Butorphanol for 8 hours by simple sedation score. Sedation Scores 0 = Alert, conversant; 1 = mildly sedated; 2 = moderately sedated and drowsy; 3 = Asleep but arousal; 4 = Asleep and not arousal At the end of study, all data were compiled and analyzed statistically using paired and unpaired statistical difference between the two groups. A P value of <0.05 was taken as statistically

RESULTS

Demographic data in both the groups was comparable (Table 1). The mean duration of analgesia was calculated from the time of first dose of epidural butorphanol to the time when patient experienced pain i.e.VAS score of 1. In group A, it was 187 ± 29.14and in group B, it was 201± 33.56 minutes. The difference between the two was statistically not significant (Table 2). At the end of 2hours 30minutes, the number of patients who were pain free were 25 in group A and 27 in group B, the difference being statistically non significant. At 3hours, 22 patients had VAS score of 1 in group A and 16 in group B while 2 patients in both group had VAS score of 2.The result was statistically not significant.At 4 hrs, 28 patients had VAS score of 1-3 each in group A and group B.2 patients in both groups had VAS score ≥4 and were given rescue analgesia. The results were statistically not significant. At 5 hours, 15 patients in group A and 14 patients in group B had VAS score ≥4 and the results were statistically not significant.At 6 hours, 11 patients in group A and 14 patients in group B had VAS score ≥4 and were given rescue analgesia. The results were statistically not significant.None of the patients in both groups remained under observation for postoperative analgesia till 8 hours, which was the study period (Table 3 and Graph 1). Postoperatively, nausea and vomiting was observed in 1 patient in both group A and group B. Pruritis was observed in 1 patient in group B and not observed in any patient in group A. No patient had urinary retention and respiratory depression in either group. The difference in incidence of these side effects was statistically not significant (Table 4). After 30 minutes, 23 patients in group A and 15 patients in group B were mildly sedated (S1), while 11 patients in group B were moderately sedated(S2) compared to 0 patients in group A. The difference was found to be statistically significant. After 1 hour, 17 patients in group A and 11 patients in group B were mildly sedated (S1). At the same time, 1 patient in group A and 17 patients in group B were moderately sedated (S2). One patient in group B was asleep but arousal. This difference was found to be statistically significant. After 1 hour 30 minutes, 6 patients in group A and 14 patients in group B were mildly sedated (S1). At the same time, 10 patients in group B were moderately sedated (S2) compared to 0 patients in group A. The difference is statistically significant. After 2 hours, 1 patient in group A and 3 patients in group B were mildly sedated(S1). At the same time, 1 patient in group B and no patient in group A was moderately sedated i.e(S2) .The difference was found to be statistically significant. Henceforth none of the patients in either groups complained of sedation(Table 5and Graph 2).

DISCUSSION

The present study was comprised of 60 patients of ASA class I or II, aged 20-70 years, weight between 40 – 80kgs and undergoing elective lower limb orthopaedic surgery. All patients were randomly assigned to one of the two groups of 30 patients each. Group A - Comprised of 7 females and 23 male patients of mean age 44.70 ± 11.05 years, mean weight 59.93 ± 6.36 kg and height of 164.40 ± 7.74 cm who received 1mg of inj. Butorphanol diluted upto 10 ml of Normal Saline and given epidurally. Group B – Comprised of 5 females and 25 male patients of mean age 47.17 ± 10.04 years, mean weight 60.73 ± 7.14 kg and height of 164.80 ± 6.74 cm who received 2mg of injection ofButorphanol diluted upto 10 ml of Normal Saline and given epidurally. A drug such as butorphanol a mu-agonist / antagonist and S / K agonist might be expected to be useful in the management of post-operative pain (Bromage P. R. et al 1982 17). Demographic data in both the groups was comparable (Table 1). The time interval between the first dose of epidural butorphanol and the time of onset of pain in the patient (i.e. VAS score of 1) was taken as the duration of analgesia. The patients underwent various types of lower limb orthopaedic surgeries which was comparable in both the groups. The mean duration of analgesia in group A was 187 ± 29.14 mins and in group B was 201± 33.56 mins (Table 2). The difference in duration of analgesia between the two groups was statistically not significant. Our study did not correlate with studies conducted by J. S. Naulty et al (1984)8 , Abboud et al (1987)26, W.E. Ackerman et al (1988)28, of epidurally administered butorphanol in different dosesfor postoperative analgesia in patients undergoing elective caesarean section which reported a stastistically significant post operative analgesia in patients receiving epidural butorphenol in doses of >1mg compared to doses of 1mg. Our results correlated with the study conducted byCatherine. O. Hunt et al (1989)1 , Q.T. Palacios, M. M. Jones (1991)19 , J. L. Howkins et al(1991)19 Pramila Malik et al (2006)18, according to which it was evident that in both groups i.e. 1mg and 2mg butorphanol administered epidurally provided effective longer duration of analgesia..Slightly longer duration of analgesia in group B i.e. 2 mg group but the difference is statistically not significant (p value < 0.05). In our study, the VAS score of 1-3 was considered as mild painandscore of 4 or >4 was considered as moderate painandrescue analgesia was given at this point of time. On comparing the VAS scores of two groups(Table 3), which shows the number of patients at different time intervals and number of patients requiring rescue analgesia, at the end of 2 hours 30 minutes, 3 hours, 4 hours, 5 hours, 6 hours,were similarandresults were not statistically significant. The findings in our study correlated with the studies conducted by D. Lawhorn et al (1991)2 , Q.T. Palacios, M. M. Jones et al (1991)19, David R. Gambling et al (1994)3 , Pramila Malik et al (2006)18 , according to which there was no statistical significant difference in VAS scores at varying time intervals in patients receiving 1mg and 2 mg of epidural butorphanol. In our study, pulse rate, systolic blood pressure and diastolic blood pressure remained stable in the post operative period and difference between the 2 groups was not statistically significant (p > 0.05), which were well supported by the studies conducted by Catherine O’ Hunt et al (1989)1 , Q.T. Palacios, M. M. Jones et al (1991)19, Pramila Malik et al (2006)18 . In our study, the incidence of nauseaandvomiting in both groups was minimalandstatistically not significant (Table 4). The incidence of prutitis in patients who received 2mg of butorphanol was 3.3% which correlated with studies conducted by Ackerman et al (1988) 28 - 6.7%, Palacios et al(1991)19 - 1.4 %, Pramila Malik et al(2006)18 - 3% respectively. According to our study (Table 5), the sedation scores at varying time intervals of 30 mins, 1 hour, 1hour 30 mins and 2 hrs were higher in patients receiving 2mg of butorphanol as compared to those receiving 1mg. Thus, the sedation scores were higher in group B when compared to group A, but none of the patients developed respiratory depression i.e. respiratory rate 2mg compared to those receiving 1mg

SUMMARY AND CONCLUSION

The present study comprised of 60 patients of ASA class I or II, aged 20 – 70 years, weighing between 40-80Kgs and undergoing elective lower limb orthopaedic surgery and were randomly assigned to one of the two groups of 30 patients each to receive either. Group A – 1mg of Butorphanol diluted up to 10ml of Normal saline and given by epidural catheter. Group B – 2mg of Butorphanol diluted up to 10ml of Normal saline and given by epidural catheter. The duration of postoperative analgesia was calculated from the time of first dose of epidural butorphanol to the time when patient again experienced pain (VAS score of 1). Epidural Butorphanol, in doses of both 1mg and 2mg are effective means of providing postoperative analgesia. The duration of analgesia with 1mg of epidural Butorphanol is 187 ± 29.14 minutes and the duration of analgesia with 2mg of epidural Butorphanol is 201 ± 33.56 minutes. The duration of analgesia provided by 2 mg of epidural butorphanol is slightly longer than 1mg of epidural Butorphanol, but the difference is statistically not significant. Epidural Butorphanol in doses of 1mg and 2mg, both provide good quality of postoperative analgesia as determined by the Visual Analogue Scale scores in the postoperative period. Haemodynamic changes i.e. Pulse rate, Systolic B.P, Diastolic B.P. were comparable throughout the study period. On comparing the changes in these parameters in each group at various time intervals with the preoperative value, it was found that the difference is statistically not significant in both the groups. Therefore it can be concluded that the haemodynamic changes in both the groups were acceptable. Epidural Butorphanol in doses of 1mg and 2mg had minimal incidence of side effects and the difference between the two groups was statistically not significant. Sedation scores in 2mg Butorphanol group i.e. Group B were higher after 30 minutes, 1 hour, 1 hr 30 mins and 2 hours interval than in 1mgButorphanol group i.e. Group A. The difference is statistically significant.(p value < 0.05).But the duration of sedation in the two groups was comparable and the difference was not statiticallysignificant. 

ACKNOWLEDGEMENT

Our sincere thanks to the post graduate students and attendants of Dept of Anaesthesiology and HOD Dr C. B. Upasani. We are thankful to all the patients

for their co-operation. Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles / journals and books from where the literature for the article has been reviewed and discussed.

References:

REFERENCES

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A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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