International Journal of Current Research and Review
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IJCRR - 14(8), April, 2022

Pages: 16-25

Date of Publication: 19-Apr-2022

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Preliminary Study on the Composition of Nanoparticles for the Treatment of Peptic Ulcer

Author: Shubhrajit Mantry, Sahil Shaikh, Shubham Shinde, Shital Bidkar, Ganesh Dama

Category: Healthcare

Abstract:One of the most frequent gastrointestinal issues is a gastric ulcer. Throughout their lives, peptic ulcer disease affects more than 10% of the adult population in Western countries. The pathogenesis of peptic ulcer disease is based on an imbalance between mucosal defense factors (bicarbonate, mucin, prostaglandin, nitric oxide, and other peptides and growth factors) and hazardous chemicals (acid and pepsin). Certain acid-related illnesses can be addressed and prevented by lowering gastric acidity or improving mucosal protection. In the treatment of stomach ulcers, nanoparticles are being developed for antiulcer drug delivery. Other treatments, such as nanotechnology, are gaining prominence as a result of the challenges in treating peptic ulcers. Different types of nanoparticles have strong antibacterial properties, polymeric nanoparticles have advantages in drug delivery and drug protection and membrane-coated nanoparticles have prominent properties of indirect targeting, demonstrating the importance of nanotechnology in the development of new peptic ulcer treatments. The pharmacokinetic performance and ulcer healing response of an antiulcer medicine in the form of nanoparticles were evaluated in Wistar rats with produced ulcers during characterization. The size distribution of the drug-filled particles was limited, with a size of approximately 200 nm.

Keywords: Proton Pump Inhibitor, Peptic Ulcers Disease, Gastro-intestinal track, Nanoparticles, Nonsteroidal Anti-inflammatory Drug, Nano- Materials

Full Text:


Acids and pepsin cause ulcers on the lining of the duodenum and stomach, causing peptic ulcers (PUD). PUD is caused by an imbalance between protective factors such as prostaglandins, blood flow, and cell regeneration and aggressive factors such as alcohol abuse, smoking, Helicobacter pylori colonization, and the use of nonsteroidal anti-inflammatory drugs.1

Peptic ulcer (PUD) is a term used to describe a wound in the gastrointestinal tract (GIT) that reaches the inner, submucosal, and possibly outer muscle layers, causing perforation and death. Organ wall lead. The disease affects a significant portion of the world's population and increases public health costs. Ulcers are a common condition that affects people around the world. Symptomatic treatment of ulcers hurts health due to unpleasant side effects. Many herbs and secondary metabolites are currently used to treat ulcers.2

Traditional oral treatments are well known. However, drug degradation in the gastrointestinal environment, reduced oral bioavailability and lack of drug delivery to the target site can reduce the effectiveness of this treatment. After this approach, it becomes attractive to use tactics to improve the effectiveness of these traditional medicines.1 For better effect, the particle size of the formulation in the nanometer range is preferred for high penetration efficiency. Therefore, the composite material is prioritized over the nanoparticles formed. Nanomaterials are gaining importance in innovation due to their adjustable physical, chemical, and biological properties, and their superior performance compared to bulk materials. The size, composition, shape, and origin of nanomaterials are all factors that need to be considered.3

Role of nanoparticles in peptic ulcer-

Nanoscale devices less than 50 nanometresin diameter can easily penetrate most cells, while devices less than 20 nanometresin diameter can easily exit the blood arteries as they circulate through the body. Due to their small size, nanoscale devices can easily interact with biomolecules both on the surface and inside the cell. As a result, it is made of high molecular weight nanoparticles that can be used to treat ulcers.4The production of high molecular weight nanoparticles by high-speed homogenizer and ultrasonic technology increases the solubility and absorption of the drug, increasing its availability at the action site and the therapeutic index.5In peptic ulcers, sucralfate is a topically active chemical that combines with hydrochloric acid in the stomach in an acidic environment to produce a pasty, viscous crosslinker capable of serving as an acid buffer for up to 6 to 8 hours after a single dose in an acidic environment6. This project creates polymeric nanoparticles, reducing the available particle size and increasing treatment efficiency7. Due to the formation of a polymeric coating, the absorption rate is also increased in the stomach and intestine.8 Using an ultrasonic homogenizer is very efficient in reducing soft and hard particles. Homogeneity is based on cavitation9. When a liquid undergoes intensive sonication, the sound waves propagate through the liquid, causing alternating high-pressure and low-pressure cycles (approximately 20,000 cycles/sec).10

The epithelium of the small and large intestines is in intimate contact with ingested material to absorb nutrients. Disaccharides, peptides, fatty acids, and monoglycerides are produced in the small intestine, then converted and absorbed in the villi. Due to electrostatic repulsion and trapping means, charged particles such as carboxylate polystyrene nanoparticles or those made from positively charged polymers have limited oral bioavailability 11. The smaller the diameter of the particles, the faster they can pass through the mucus and reach the colon cells; a Diameter of 14 nm penetrates in 2 min, the diameter of 415 nm penetrates in 4 min. particles look 30 min while 1000 nm particles cannot shift this barrier.12

Ulcer Anatomy & Pathophysiology-

An ulcer is a continuous rupture of the covering epithelium, whether it is the skin or the mucosa, due to molecular death. An ulcer is a rupture or rupture of the inner lining of the body that prevents a membrane-bound organ from continuing to function normally. An imbalance between protective and destructive factors in the gastrointestinal tract lining causes peptic ulcer disease. duodenum (PUD). Risk factors for PUD include H. pylori infection, NSAID use, first-degree relative with PUD, migration from developed countries, and African-American/Hispanic ethnicity. A mucosal defect extending to the muscular mucosa is common with peptic ulcers. The inner layers are susceptible to acid when the mucous membrane that protects the surface is damaged. The ability of mucosal cells to release bicarbonate is also impaired. H. pylori is known to localize and inflame the gastric mucosa. H. pylori also inhibits bicarbonate release, promotes metabolism, and increases gastric acidity.12

Preliminary test for peptic ulcer-

Stool monoclonal antigen tests-

When using a laboratory-certified monoclonal test, fecal antigen screening uses a monoclonal antibody that is as accurate as of the urea breath test 16. The urea breath test is more expensive and requires more equipment. Similar to how a urea breath test only detects an existing infection, a stool antigen test can be used as a curative test. PPIs should avoid for two weeks before testing, but stool antigen testing is not as affected as urea breath tests using PPIs. 17

Mechanism of Action of drug -

Finally, PPIs work by reducing gastric acid secretion. These drugs are absorbed near the small intestine and then released into the circulation, where they affect the stomach’s parietal cells.18 The enzyme H+/K+ ATPase, or proton pump, is found in parietal cells and is blocked by PPIs. The penultimate stage in gastric acid secretion is this enzyme. PPIs are active precursors in the acid-secreting tubules of parietal cells only after acid-catalyzed cleavage. PPIs are broken down by the liver enzyme P450.19 Though there are slight differences in which the P450 enzyme predominates in breaking down some PPIs, CYP2C19 is the most common.14Understanding how PPIs are metabolized can help us understand why certain PPIs work better for some people than others. For example, people of Asian descent have higher bioavailability of PPIs and should start at a lower dose. The bioavailability of PPIs increases with age. Therefore, the dosage in the elderly should be checked frequently and changed as necessary. PPIs are the most effective drugs to reduce acid production in the stomach.15

Figure. 3 - Schematic representation of the major pathophysiological mechanisms involved in the pathogenesis of peptic ulcer disease and the sites of action of the most commonly used pharmacological treatment options for peptic ulcer disease. CCK2 = cholecystokinin receptor; PGE2 = prostaglandin E2; PGI2 = prostaglandin I2; EP3 = prostaglandin E3 receptor; HIST = histamine. 21

Role of additives for nanoparticles drug targeting-

Organic Solvent-

Organic solvents recognized as neurotoxins include hexane, tetrachlorethylene, and toluene. Fatty and aromatic hydrocarbons, amines, esters, ethers, ketones, and nitrated or chlorinated hydrocarbons are all examples of organic solvents.16


Allows the modification of ligand surfaces for stealth and drug delivery, ensuring the stability of labile molecules. e.g. Gelatine, lecithin, albumin17.


Surfactants reduce the average particle size by changing the surface energy of the particles. As a result, the surface tension decreases, and the Kelvin barrier changes, allowing more particles to avoid agglomeration18.

Aq. Solvent-

The aq. Solvents are used to dissolve the surfactant and form a solution19.

Production technique used in particles –

Solvent Evaporation Method –

Solvent evaporation was the original approach to producing macromolecular NPs from a prefabricated polymer. The production of an oil-in-water (o/e) emulsion is required for this process, which leads to the synthesis of nanoparticles 25. The whole process is described, to begin with, an organic phase is produced using a polar organic solvent, in which the polymer is dissolved and the active ingredient (eg a drug) is decomposed. canopy. Both chloroform and dichloromethane have been used extensively in the past, but more often in the past. Due to their toxicity, they have been replaced by ethyl acetate, which is more toxic and therefore more suitable for biomedical applications 20. Aqueous phases containing surfactants (eg polyvinyl acetate; PVA) were also frequently produced. The organic solution is emulsified in the aqueous phase with a detergent and processed into a nanodroplet dispersion using high-speed homogenization or ultrasonic waves. Evaporation of the polymeric solvent that can diffuse into the continuous phase of the emulsion results in a suspension of NP. The solvent is expelled either by continuous magnetic stirrer at room temperature (for more polar solvents) or constant depressurization (as for dichloromethane and chloroform). The cured nanoparticles can then be washed and collected by centrifugation, and after the solvent has evaporated, they can be lyophilized for long-term storage21.

Emulsions - Diffusion Method-

This is due to Leroux et al. The patented approach is a modified version of the salting-out process. The polymer was dissolved in a water-miscible solvent (propylene carbonate, benzyl alcohol) and then the solution was saturated with water 28. The solvent phase saturated with polymer water is emulsified into an aqueous solution containing stabilizers29. Then the solvent is removed by evaporation or filtration 30. The advantages of this approach are excellent encapsulation efficiency (typically 70%), minimal homogenization requirements, high batch-to-batch reproducibility, easy scaling, simplicity, and limited size distribution31. The leakage of water-soluble drugs into the saturated aqueous outer phase during emulsification reduces encapsulation efficiency, which is a drawback of this approach 32.

Characterization of nanoparticles- 


Scanning and transmission electron microscopes (SEM and TEM) are widely used to learn more about the shape and size of polymer NPs. To analyse the morphology of NP, NP is often used in combination with cryofracture technology. Electron microscopy (TEM) is often used to distinguish between nanocapsules and nanospheres and to measure the wall thickness of nano-capsules. Nanospheres have a spherical, solid polymer structure, while nano-capsules have an oily core surrounded by a thin polymer shell (about 5 nm). Atomic force microscopy is another approach that has been used to analyse the surface morphology of macromolecular NPs (AFMs)33.

Particle size and size distribution-

Microspheres were suspended in liquid paraffin and observed with an optical microscope. The size distribution of the microsphere was investigated using laser diffraction technology (Malvern Instruments Ltd., Malvern, UK). Average particle size was calculated and reported in micro-meters using cyclohexane as a dispersant 34.

The yield of Nanoparticles-

The total weight of the nanoparticles produced was compared to the total weight of the copolymer and the drug to calculate the nanoparticle yield. 35

Entrapment efficiency-

The nanoparticles were separated from the dispersion by centrifugation at 22,000 rpm for 25 min. The supernatant obtained after centrifugation was appropriately diluted and analysed for free diazepam by UV-Visible spectrophotometer at specific nanometres. The trap effectiveness percentage is calculated as follows 36

Drug Content analysis-

Properly weigh 10 mg of microspheres into a clean 100 ml volumetric flask, dissolve in approximately 2 ml of acetone, adjust the volume with a pH 7.4 buffer, then increase the volume with a pH 7.4 buffer for marking. Rice field. completely. After filtration and dilution, samples were analysed spectrophotometrically to estimate drug concentrations in microspheres. The drug content of each sample was averaged in three separate tests. The containment efficiency of microspheres was estimated by dividing the actual drug content by the theoretical drug content of microspheres 37

Stability of Nanoparticles-

The storage of optimal formulations at 4°C 1°C and 30°C 2°C in a stabilization chamber for 90 days determines the stability of the resulting nanoparticles. Samples were examined for drug content, drug release rate (t50%), and any changes in appearance after some time, such as 0, 1, 2, and 3 months 38

Drug-Excipients Compatibility Studies-

Excipients are essential components of almost all pharmaceutical dosage forms, so it is essential to investigate any physical or chemical interactions between the drug and the excipients, as excipients can change in drug bioavailability and stability. To create a product that is stable, effective, attractive, easy to use, and safe, drugs and excipients must be compatible. Compatibility studies are especially important if the excipients are new and have never been used in formulations containing the active ingredient. To test drug compatibility with different excipients used, DSC and FTIR techniques have been widely used 39

Pharmacokinetic study-

We generated three groups of four Wistar rats (250-300 g) with ulcers. Drugs with NaHCO3 solution (5 mg/kg) or drug formulation (5 mg/kg) were administered to Wistar rats. Blood samples were obtained from the tail vein of each rat before drug treatment and at levels of 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10, 12, and 24 h after dosing. The supernatant was collected after centrifugation of the blood sample at 12,000 rpm for 10 min at 4 °C. Using acetonitrile and centrifugation, the drug formulation of each sample was extracted. The supernatant was collected, dried, and reconstituted using the mobile phase for HPLC analysis. The number of drug formulations that can be recovered from serum samples has been calculated. Using a non-inhibitory pharmacokinetic analysis model, pharmacokinetic parameters were calculated.40

Pharmacodynamic study-

Wistar rats with ulcer-induced ulcers were divided into four groups (n = 4) and received saline (control group), drug solution, or capsule containing the drug formulation. For 7 days, the formulations were administered orally once daily. After 24 h, the mice were dead. The stomach was sectioned along the greatest curvature and its mucosal surface was cleaned with saline solution 40. The total mucosal area and ulcerated area were measured using Axio Vision software after imaging the gastric mucosa. The equation used to determine ulcer index (IU)

Biodistribution of nanoparticles in stomach tissue-

Male Wistar rats weighing 250-300 gms were used in this investigation, and they were obtained from the local Laboratory Animal Center. All animal experiments followed the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals, and all procedures were reviewed by the Animal Research Ethics Board. During the night, the rats were fasted but were given free water. Oral doses of 100% ethanol (5 ml/kg) cause gastric ulcers. The ulcer-induced mice were divided into three groups, with four mice each (one control and two treatment groups). The treatment groups received ready-to-use drugs, while the control groups received only physiological saline. Formulas were used orally 1 h after ethanol administration40 Four after receiving the dose, the rats were slaughtered. The stomach is opened longitudinally and saline solution is rubbed. Stomach tissue was divided into ulcerated and non-ulcerative sections, and freshly removed tissue was frozen using Tissue Tek. A CM3050 S cryostat was used to segment the molded tissue sample, which was then examined under a fluorescence microscope with an integrated digital microscopy system.41 Hematoxylin and eosin were also stained with hematoxylin and eosin to show healthy and ulcerated tissue morphology. The total mucosal area and ulcerated area were measured using Axio Vision software for quantitative determination. Ulcerated and non-ulcerative tissues were lyophilized separately in the dark. Each tissue sample was sonicated for 15 min after immersion in acetone. The supernatant was obtained after centrifugation of those tissue samples for 5 min at 2000 pm. Three times the extraction process was performed. Finally, the supernatant was diluted with acetone and examined with a fluorescence spectrometer at 430 nm and 490 nm. The absorption ratio of nanoparticles per cm2 of gastric tissue, whether ulcerated or not, was used to calculate the absorption of nanoparticles. 42


According to evaluations of multiple papers, reducing the particle size of the dosage form increases porosity and permeability, which increases bioavailability and therapeutic efficacy, and this phenomenon is useful for treating peptic ulcers. Proton pump inhibitors are the best category of the drug in polymeric nanoparticle form, according to the review, and produce better results than other drug categories. When standard dose forms are compared to novel drug delivery systems (NDDS) dosage forms, we discover that NDDS is more effective and patient compliance is higher.


We can treat PU with high drug potency, bioavailability and efficacy by using formulations containing NPs, resulting in reduced dosing frequency. A lot of research has been done to better understand how nanoparticles heal peptic ulcers, but one of the 4,444 hardest parts of characterizing is their microscopic size. The charge carriers are about 200 nm in size and narrow in size distribution. Nano-sized devices with a diameter of fewer than 50 nanometres can easily enter most cells, while those with a diameter of fewer than 20 nanometres can easily exit blood arteries as they travel. in the body. Nanoscale devices can easily interact with biomolecules both on the surface and inside cells due to their small size.


The authors express their sincere gratitude to Sharad Chandra Pawar College of Pharmacy, College of Pharmacy, Our, University Libraries, and all other sources for their cooperation and advice in writing this review.

Source of Funding-


Conflict of Interest: Nil

Author Contribution-

All authors contributed equally towards the data collection, data analysis & compilations.


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[52] Rodrigues DF, Do Couto RO, Sinisterra RD, de Jensen CE. “Novel eudragit-based polymeric nanoparticles for sustained release of simvastatin,” Brazilian J. Pharm. Sci., vol. 56, pp. 1–12, 2020, doi: 10.1590/s2175-97902019000418363.

[53] Tavares EJM, De Araújo DR, Fraceto LF. “Ivermectin-loaded polymeric nanoparticles: Screening the effects of polymers, methods, and the usefulness of mathematical models,” J. Nanosci. Nanotechnol., vol. 17, no. 6, pp. 4218–4234, 2017, doi: 10.1166/jnn.2017.13111.

[54] El Hady WEA, Mohamed EA, El-Aazeem Soliman OA,El-Sabbagh HM. “In vitro-in vivo evaluation of chitosan-PLGA nanoparticles for potentiated gastric retention and anti-ulcer activity of diosmin,” Int. J. Nanomedicine, vol. 14, pp. 7191–7213, 2019, doi: 10.2147/IJN.S213836.

[55] Safarov T, Kiran B, Bagirova M, Allahverdiyev AM, Abamor ES. “An overview of nanotechnology-based treatment approaches against Helicobacter Pylori,” Expert Rev. Anti. Infect. Ther., vol. 17, no. 10, pp. 829–840, 2019, doi: 10.1080/14787210.2019.1677464.

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[57] Ramesh KD, Amol K, Jaydeep P.“Formulation and in-vitro Evaluation of floating tablets of Antibiotics used in the treatment of Peptic ulcer,” vol. 11, no. 1, pp. 1–7, 2021, doi: 10.5958/2231-5713.2021.00004.0.

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[62] Gupta R, Prajapati SK, Pattnaik S, Bhardwaj P. “Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study,” Asian Pac. J. Trop. Biomed., vol. 4, no. 9, pp. 729–735, 2014, doi: 10.12980/APJTB.4.201414B73.

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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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SCOPUS indexing: 2014, 2019 to 2021

Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to for more details.

Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award

A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award

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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.


International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal


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