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IJCRR - 14(2), January, 2022

Pages: 29-35

Date of Publication: 16-Jan-2022


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Influence of Mini-Scleral Contact Lens Wear on Cornea in Ectatic Corneal Disorders

Author: Simi Afroz, Khowal Ritesh, Dubey Gaurav, Jamshed Ali, Yadav Juhi, Das Prasenjit, Manik K. R.

Category: Healthcare

Abstract:Introduction: Scleral lenses are gaining popularity in places where contact lenses are fitted. MSCL's sub-group of scleral contact lenses with a total lens diameter between 14 and 18 mm, which rest entirely upon the sclera. Aim: The study aims to evaluate the influence of mini-scleral contact lens (MSCL) wear on corneal shape, thickness, and higher-order aberration after the lens settled on the eye for 4 to 6 hours in non-inflammatory ecstatic corneal disorders. Purpose: The study aims to check the change in corneal curvature and thickness after settling the lens on the eye for 4 to 6 hours. Also, check if there is any change in corneal aberration just after insertion and after settling the lens for 4 to 6 hours. Methods: This study was a prospective Cross-sectional experimental study to prove what was hypothesized in advance. Scheimpflug imaging was done for 15 subjects (mean age 26.4(\?6.57)), first before insertion of mini-scleral contact lens. Second, just after wearing the mini-scleral contact lens. Third, after 4 to 6 hours of wearing of mini-scleral contact lens. Fourth, just after removal of MSCL in non-inflammatory ecstatic corneal disorder patient. Natural diurnal variations were considered by measuring separate control groups. Results: Small but significant increase in corneal thickness was observed just after removal of the lens after 4 to 6 hours of wearing (from 447.2(\?46.8) to 457.8(\?50.35) µ) P=0.023. After 4 to 6 hours of wearing, significant flattening of steep and steepest corneal curvature was observed having mean (0.0524(\?0.085) mm, 0.933(\?1.6) D respectively (P=0.032). Conclusion: Increase in corneal thickness, and significant flattening of steep corneal curvature was observed immediately after removing the lens after 4 to 6 hours of wearing. Modern MSCL decreases both higher and lower order aberration immediately after wearing the lens. Modern mini scleral lenses influence the corneal shape and induce small but significant corneal oedema after 4 to 6 hours of wearing.

Keywords: Mini scleral contact lens (MSCL), Corneal Aberrations, Corneal thickness, Ecstatic cornea, Keratoconus, RGP Contact Lens

Full Text:

Introduction
Scleral lenses are gaining popularity in places where contact lenses are fitted. MSCL’s a sub-group of scleral contact lenses with a total lens diameter between 14 and 18 mm, which rest entirely upon the sclera, is sealed to the anterior eye with minimal movement upon blinking or ocular versions (Sindt, 2008).1 They are primarily used to correct irregular corneal optics commonly encountered in Keratoconus, Keratoglobus, Post LASIK Ectasia, as the post-lens tear layer (the fluid reservoir between the posterior lens and anterior cornea) effectively neutralizes most of corneal astigmatism. More recently, scleral lenses have also been utilized as a therapeutic intervention in cases of ocular surface disease (e.g., Exposure Keratopathy, Sjogren's syndrome, Steven–Johnson's Syndrome) as they provide hydration to the cornea during lens wear without evaporation. Previously, scleral lenses were larger in diameter, and the fitting was empirical and primarily relied upon practitioner interpretation of haptic (landing zone) vascular compression of the bulbar conjunctiva. Newer technology and advancements in anterior eye imaging with corneal topography and optical coherence tomography have resulted in a more reliable and accurate fitting process. Improved lens design led to the increase in the prescription of scleral lenses. This has led to a subsequent increase in the scleral contact lens prescription. Scleral lenses are significantly thicker (up to 1300 µ central thickness for full scleral lenses) than corneal rigid gas permeable (RGP) lenses to avoid the eye and handling flexure. Consequently, to counteract this increased thickness, modern scleral lenses are manufactured from highly permeable materials to maximize oxygen transmission to the cornea (Vincent, 2014).2 This is particularly important since scleral lenses do not move upon blinking to allow freshly-oxygenated tears to replenish the post-lens tear layer.Post-lens tear thickness varies from lens to lens, cornea to cornea and practitioner to practitioner. It may act as an additional barrier to the corneal oxygen reaching the atmosphere. The increased lens thickness, poor tear exchange and the presence of a thick post-lens tear layer are all possible hypoxia variables, however clinical reports of substantial corneal oedema associated with current scleral lens usage are rare. There have been several investigations into the corneal response to scleral lens wear in an attempt to quantify it. In an early study using full scleral lenses, Bleshoy and Pullum reported corneal edema in a single subject following 5hrs of sealed scleral contact lens wear using an RGP material with a Dk of 24. Central lens thickness was varied from 180 to 500 µ, and corneal swelling increased slightly with increasing lens thickness from 3.6% to 4.8% centrally and 4.6–5.3% in the periphery (although these central and peripheral zones were not defined). More recently, Pullum and Stapleton assessed central corneal swelling for four subjects following 3 hours of sealed scleral lens wear while varying lens thickness and oxygen permeability. Sclera lenses with a thickness of 1200 and a Dk of 32 showed up to 8% corneal edema, although this decreased as the lens thickness was reduced and the Dk increased. Other studies have looked at how well scleral contact lenses fit (such as apical clearance) and how they affect vision and ocular health (such as enhanced acuity, lens tolerance, and problems).This study assessed the physiological changes in corneal characteristics (biometrics and optical properties including anterior higher order aberrations) associated with modern MSCL wear. Scheimpflug imaging was used to investigate the influence of MSCL wear on the irregular cornea, young subjects with the ecstatic non- inflammatory irregular cornea (i.e., keratoconus or corneal abnormalities including ocular surface disease) over a substantially larger corneal region than previously examined. There are some drawbacks to correcting higher-order aberrations in normal eyes, including the fact that the eye is a dynamic optical and biological system. Consequently, the optical aberrations measured and corrected one day may not yield the same level of visual improvement on another day (Jinabhai, 2009). 3 Jinabhai study also reports that aberration measurements can come from accommodation fluctuations, tear film fluctuations, small eye movements and pupil size changes (Jinabhai, 2009). 3Simply said, correcting aberrations in normal eyes is like correcting a little fluctuating value. Despite the disadvantages for normal eyes, higher-order aberration contact lenses could improve vision in ecstatic eyes due to the huge magnitudes of optical aberration present in these patients. The practicality of ecstatic eye contact lenses with aberration control is being studied. Correction of these optical imperfections would greatly improve joyful eyes' visual performance. The first step is to precisely measure sick optical defects. To explain the optical distortions, present in the ecstatic cornea. It will also assess the progress made in correcting them with micro scleral contacts. Currently, these tailored lenses only partially correct higher-order aberrations in keratoconus eyes. The use of aberration-controlling contact lenses in non-inflammatory ecstatic eyes is investigated in this research. Currently, aberration-controlling contact lenses seem realistic. If designers can create bespoke lenses with precision and movement stability. The study aims to estimate the change in corneal curvature and thickness after settling the MSCL on eye for 4 to 6 hours and to evaluate the change in aberration after settling the lens for 4 to 6 hours.The Stephen study concludes that Modern mini-scleral contact lenses that vault the cornea may slightly influence corneal shape and power but do not induce clinically significant corneal oedema during short-term wear. (Stephen J. Vincent, 2014).3,4 Pullum says in his study that the calculations of oxygen transmissibility, with varying tear layer and lens thicknesses, ranged from 10 to 36.7 at the scleral lens centres and from 17.4 to 62.6 at the peripheries. Their calculations of maximum central lens thicknesses show a practical range of 250–495 µm, in conjunction with a post-lens tear layer thickness of 100–250 µm. He also used the Holden–Mertz Dk/t criteria of 24 Fatt units for the central cornea. The Harvitt–Bonanno criteria of 35 Fatt units for the limbal area were used as reference points (Pullum, 1997).5 Article by customized lenses is found to correct only partially the higher-order aberrations found in keratoconic eyes. Suppose contact lens designers can manufacture customized lenses with accuracy and good movement stability. In that case, aberration-controlling contact lenses could prove to be a very useful tool for those involved in managing keratoconus patients (keratoconus, 2015).6 Jinabhai said the use of MSCL correcting higher-order aberrations may still be extremely beneficial in improving visual function in keratoconic eyes due to the enormous magnitudes of optical aberration observed in these patients. (Jinabhai, 2009). 3 Alio J. L., in his study, shows that the eyes with the lenses have a statistically significantly thicker cornea compared to the non-lens wearing eye after wearing either lens for 8 hours, lying within clinically and physiologically acceptable limits. Their clinical findings contradict existing theoretical estimates, which predict an increase in corneal edema as the tear layer thickness increases.It has to be evaluated if the effect on corneal oedema changes with longer wearing periods, larger samples, or other influences (Alió J. L., Corneal higher order aberrations: a method to grade keratoconus, 2006).6,7 Christiane Arlt's Despite current theoretical estimates, clinical evidence show that increased tear layer thickness does not increase corneal edema.It has to be evaluated if the effect on corneal oedema changes with longer wearing periods, larger samples, or other influences (Christiane Arlt, 2015). 8 As far as my knowledge ours is the only study done on young, healthy corneas but not on irregular or ecstatic corneas. Also, there is no study on aberration change after settling the lens for 4 to 6 hours. The study's main objective is to estimate the change in corneal curvature and thickness after settling the lens on eye for 4 to 6 hours and to check the change in aberration before and after insertion of the lens.
Methodology 
This study was a prospective Cross-sectional experimental study to prove what was hypothesized in advance. The author collected the data according to the hypothesis. The prevalence of the ecstatic corneal disorder is very low. (2300/100,000 for keratoconus) (Jonas, 2009).9 So sample size collection was based on convenient sampling. This study's inclusion criterion was Irregular cornea (ecstatic non-inflammatory corneal disorders); all subjects were between the ages of 18 yrs. to 50 yrs. with both males and females, and Post collagen cross-linking were also included. All kinds of Systemic Diseases, Presence of ocular disease except for non-inflammatory ecstatic corneal disorders), Age Group above 50 years, Age Group below 18 years, those who were absent on the day of the study, those who did not consent to participate in the study were excluded from this study All the patients presented in the visual aids centre Lajpat Nagar New Delhi were included in our study. They all took part voluntarily and without a financial refund. Ten subjects were included in the study. The average age within the sample was 34.5 years, with a standard deviation of 11 06 years at the time of the measurements. The consent form was signed, which shows their voluntary participation in my study. All the subjects had to pass the pre-fitting evaluation; the ideal diameter and base curve were chosen using the provided fitting set. If evaluation with fluorescein at the slit lamp did not look as expected, modifications were made in cooperation with the manufacturer. After finalizing the lens parameters, the lens was ordered with final refractive power incorporated in the lens. The vault used in the study is 300±25 micron. To avoid diurnal variation, the subject had to wear the lens in the morning at about 10:00 am and remove after 4 to 6 hours, about 3:00 pm. Only if all requirements were fulfilled, the lens could be used in the study. Data were coded and recorded in the MS Excel spreadsheet program. SPSS v16 was used for data analysis. Shapiro-Wilk normality test, paired-sample t-test, and Wilcoxon sign ranked test were used according to suitability and analysed data. The level of significance was taken as p < 0.05. Various graphs were used for showing the pre vs post changes of each parameter. The prior approval was taken by the hospital authority to conduct this.
Table-1
Four scans were taken in the following Sequence of the Measurement:
First, before fitting the mini-scleral contact lens.
Second, just after fitting the mini-scleral contact lens.
Third, after 4 to 6 hours of wearing of mini-scleral contact lens.
Fourth, just after removal of the mini- scleral contact lens.

Above mentioned parameters were measured. Visual acuity was measured five times using a log MAR chart in the following way
First unaided visual acuity was measured before fitting the contact lens and also without any refractive error.
Second, just after fitting the final lens.
Third after 4to 6 hours of wearing the lens.
Fourth unaided visual acuity was measured just after removal of the lens.  

RESULT
Fifteen (15) subjects (12 male and 3 Female) of mean age 26.4(±6.57). The mean apex pachymetry (micron) increased from 447.2(± 46.476) before insertion of MSCL to 457.8(±50.35) after removal of the lens after approx. 5hours. This change was statistically significant (Paired Sample-Test), ‘p’ = 0.023 (Figure- 1).
The mean of Thinnest corneal thickness before insertion of MSCL increase from 431(±38.46) to 443(± 44.34) after approx. 5 hours. This change was significant paired-sample t-test), ‘p’= 0.013 (Figure-2).

There is no significant change in the flat corneal curvature before insertion of mini scleral and just after removal of MSCL. But there is a significant change in steep corneal curvature before insertion, and just after removal of MSCL with ‘p’ = 0.032, mean value of steep corneal curvature before insertion of MSCL and just after removal of mini sclera contact lens is 6.55(±0.78) and 6.61(±0.082) respectively (Figure-3).

There is no significant change in the flat corneal curvature before insertion of mini scleral and just after removal of MSCL. But there is a significant change in steep corneal curvature before insertion, and just after removal of MSCL with ‘p’ = 0.032, mean value of steep corneal curvature before insertion of MSCL and just after removal of mini sclera contact lens is 6.55(±0.78) and 6.61(±0.082) respectively (Figure-3).

There was also a significant change in the steepest corneal curvature before insertion and just after removal of MSCL with‘p’= 0.049(Figure-4). There is a flatting of approximately 0.933(±1.6) in the steepest corneal curvature. The mean value of the steepest corneal curvature before insertion of MSCL and just after removal of MSCL are 58.57(±7.76) and 57.64(±7.85), respectively. There were no significant changes in Pmax, variance index, and irregularity index with ‘p’= 0.158, 0.619 and 0.426, respectively (Table-1).

Relation between before insertion and just after insertion of MSCL:
RMS of total aberrations before insertion of MSCL decreases from 10.397(±3.70) to 4.67(±3.05) (mean value) just after insertion of MSCL with ‘p’= 0.001, which is highly significant (Figure-5).

RMS of LOA aberration before insertion of MSCL also decreases from 10.08(±3.57) to 4.87(±2.70) (mean value) just after insertion of MSCL, which is statistically significant with ‘p’= 0.000. RMA of HOA decreases before insertion of MSCL from 2.75(±1.16) to 1.3873(±0.92) (mean value) just after insertion of MSCL, which is statistically significant with ‘p’=0.001. Spherical aberration before insertion of MSCL decreases from 0.756(±0.76) to 0.392(±0.34) (mean value) just after insertion of MSCL with ‘p’ = 0.017, which is statistically significant. Secondary astigmatism before insertion of MSCL decreases from 2.88(±2.21) to 2.013(±2.76) just after insertion of MSCL with ‘p’ =0.020, which is statistically significant. Defocus before insertion of MSCL decreases from 3.362(±2.95) to 1.33(±1.30) just after insertion of MSCL with significant ‘p’= 0.003. Trefoil aberration before insertion of MSCL decreases from 0.408(±0.29) to 0.332(±0.35) just after insertion of MSCL with ‘p’ =0.001, which is highly statistically significant. Coma aberration before insertion of MSCL decreases from 0.85(±1) to 0.627(±0.74) just after insertion of MSCL with ‘p’= 0.036, which is statistically significant.  Quadra foil, Penta foil, and hexafoil did not show statistically significant results with ‘p’ =0.394, 0.443and 0.609 (Figure-6).

Relation between just after insertion and before removal after 4 to 6 hours:
RMS of HOA further decreases from 1.387(±0.92) to 1.17(±0.87) (mean value) with ‘p’=0.047 which is statistically significant. RMS of LOA further decreases from 4.87(±2.7) to 3.847(±2.29) with a ‘p’=0.036 which is statistically significant (Table-2). Secondary astigmatism further decreases from 2.013(±2.76) to 1.107(±0.95) with a ‘p’ =0.044 which is statistically significant. Spherical aberration, Defocus, Trefoil, Coma, Quadra foil, Penta foil and Hexa foil did not show any statistically significant result having ‘p’ = 0.82, 0.394, 0.334, 0.191, 0.307, 0.307and 0.293, respectively (Figure-7).



 

Before insertion and just after removal of MSCL:
There is no statistically significant change in any aberration before insertion and just after removal of MSCL after 4 to 6 hours of wearing.
Discussion
Our best knowledge is the only Indian study that reveals statistically significant corneal oedema following 4 to 6 hours of wearing of MSCL. There is an increase in central corneal thickness following 4 to 6 hours of wearing MSCL with the mean percentage change of 0.0236, whereas Stephen Vincent et al. study says the opposite. The increase in corneal thickness is either due to hypoxia or the imbibition of saline used in MSCL or it may be a combination of both. To minimize saline imbibition, we use near equivalent composition, osmolarity, pH, and refractive index as that of tear layer. (Michaud, 2012)10 in his study concluded that scleral contact lens with Dk of 100 and lens thickness of 300 µm and corneal vault of 400 µm would yield a predicted Dk/t of 12.5, which do not satisfy Holden and Merts criteria for successful daily wear, so the clinically or statistically significant corneal swelling was observed (Michaud, 2012). 10 There is a flatting of steep corneal curvature following 4 to 6 hours of MSCL wear. Still, no significant change was noted in flat corneal curvature, whereas Vincent et al. study says overall flatting of corneal curvature. There is also a flatting of steepest corneal curvature (0.035(±0.1)) following 4 to 6 hours of MSCL wear. Analysis of change in individual Zernike coefficient up to 6th order aberration was done. But only up to 4th order aberration shows a significant change in before and immediately following MSCL wear.  When we take individual aberration into account, there is no further change after wearing 4 to 6 hours of MSCL except RMS of HOA, RMS of LOA, and secondary astigmatism shows a statistically significant decrease. RMS to LOA shows a highly statistically significant decrease in aberration. There is numerous higher-order aberration of which only spherical aberration, coma and trefoil are of clinical interest. Spherical aberration is commonly increased in myopic LASIK, surface ablation and keratoconus (non-inflammatory ecstatic corneal disorder (Michaud, 2012).10 Spherical aberration results in halos around the point image. It is statistically decreased in the ecstatic cornea after wearing MSCL. Coma is common in patients with decentred corneal graft, keratoconus, and decentred laser ablations (Michaud, 2012).10 Our study shows a statistically significant decrease in coma aberration after wearing MSCL. Trefoil produces less degradation in image quality compare with coma. It causes glare, ghost images and loss of contrast. They make up to about 15% of the total number of aberrations in an eye. (Vessel, 2020).11 LOA account for approx. 85% of the overall wave aberration in the eye. It includes positive defocus, negative defocus, and regular astigmatism. LOA mainly accounts for visual acuity, i.e., Measure of form sense. Our study shows a highly significant decrease in RMS of LOA (p-value=0.000) and the same we get by measuring visual acuity before and after insertion of MSCL (‘p’=0.001). There is a statistically significant decrease in defocus before insertion and just insertion of MSCL (‘p’=0.003).  RMS of LOA and RMS of HOA further decrease 3 hours after lens wear. Individual aberration remains content and no further change, showing that MSCL did not affect the corneal aberration after wearing short-term MSCL  (Vessel, 2020). 11There is no evidence of change in corneal aberration before insertion of MSCL and just after removal of MSCL after 4 to 6 hours of wear, which indicates that the lens does not cause any significant change in LOA. There is no evidence of change in corneal aberration just after insertion of MSCL and before removal of MSCL after 4 to 6 hours of wearing, which indicates mini scleral. This particular type of lens provides stable constant vision. Different lens materials and designs should be taken into consideration (Vessel, 2020).11
Conclusion
Corneal thickness has changed and increased after settling the MSCL on the eye for 4 to 6 hours. There is flattening of steep corneal curvature and the steepest corneal curvature (Kmax) after settling the MSCL on the eye for 4 to 6 hours. There is no evidence of change in flat corneal curvature. There is a decrease in total aberration after wearing the lens, and there is no evidence of a change in aberration after settling the lens for 4 to 6 hours of wearing. There is an increase in visual acuity just after wearing the lens. Modern MSCL decreases both higher and lower order aberration immediately after wearing the lens. Modern mini scleral lenses influence the corneal shape and induce small but significant corneal edema after 4 to 6 hours of wearing.  

Limitations
This study was a prospective Cross-sectional experimental study; further research on a more diverse group in terms of keratoconus, PMCD, post LASIK is required to arrive to reach a strong conclusion and recommendation. 
Smaller sample size.
Lack of human resources and lack of awareness among practitioners and patients.

Recommendation
We recommend a similar study with larger sample size, and a more diverse group should be considered to ascertain that similar findings will be revealed.

Acknowledgment
The authors would like to thank the higher authorities of the visual aids centre in Lajpat Nagar New Delhi for providing all possible support for the smooth conduction of this research. The authors acknowledge the immense help received from the scholars whose articles are cited and included in references to this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals, and books from where the literature for this article has been reviewed and discussed."

Conflict Of Interest
This research did not receive any outside funding or support
Source of funding-None
Ethical Statement- 
The prior approval was taken by the hospital authority to conduct this.

Authors’ Contribution:

Abbreviations:        
1.    MSCL- mini scleral contact lens
2.    MAR- minimum angle of resolution
3.    SPSS-  Statistical Package for the social sciences
4.    RMS- root mean square
5.    LOA- lower order aberration
6.    HOA-higher order aberration
7.    PMCD- pellucid marginal corneal degeneration
8.    LASIK- laser-assisted in situ keratomileusis

References:

  1. Sindt C. Basic scleral lens fitting and design. Contact Lens Spectrum. 2008; 23(10), 10.

  2. Vincent S. J.-C.Corneal changes following short-term mini scleral contact lens wear. contact lens and anterior eye.2014; 37(6), 461-468.

  3. Jinabhai A. R. Higher-order aberrations in keratoconus: A review. optom. pract.2009

  4. Stephen J. Vincent, D. A.-C.  Corneal changes following short-term mini scleral contact lens wear. Contact Lens & Anterior Eye.2014 37, 461–468.

  5. Pullum, K. W. Scleral lens-induced corneal swelling: what is the effect of varying Dk and lens thickness? The CLAO journal: official publication of the Contact Lens Association of Ophthalmologists, Inc.1997; 23(4), 259-263.

  6. Keratoconus, O. E.  The Epidemiology and etiology of keratoconus. International journals of keratoconus and ectatic corneal disease.2015; 7-15.

  7. Alió, J. L. Corneal higher-order aberrations: a method to grade keratoconus. Journal of Refractive Surgery.2006; 22(6), 539-545.

  8. Christiane Arlt, P. P.Clinical Effect of Tear Layer Thickness on corneal edema during scleral lens wear. alien university.2015; 1-79.

  9. Jonas, J. B.  Prevalence and associations of keratoconus in rural Maharashtra in central India: the central India eye and medical study. Am. J. Ophthalmol.2009;148 (5), 760-765.

  10. Michaud, L. V. Predicting estimates of oxygen transmissibility for scleral lenses. Contact Lens and Anterior Eye.2012; 35(6), 266-271.

  11. The vessel, M.2020 AAV Media, LLC. Retrieved from www.allaboutvision.com:https://www.allaboutvision.com/conditions/aberrations.html

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A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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