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IJCRR - 13(21), November, 2021

Pages: 116-123

Date of Publication: 09-Nov-2021


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To Evaluate the Effect of Different Margin Designs on Marginal Accuracy and Fracture Resistance of Zirconia Core Restorations

Author: Milani Neha, Jagtap Amit, Attargekar Vikas, Athavale Smita, Dange Bhagyashree, Gandage Dhananjay

Category: Healthcare

Abstract:Introduction: The strength of all-ceramic restoration depends not only on the fracture resistance of the material but also on a suitable preparation design that provides adequate material thickness. Objective: The purpose of the study was to evaluate the property of fracture resistance and marginal accuracy of zirconia core restorations with two different margin designs. Methods: Two stainless steel dies, with deep chamfer and shoulder margin designs were fabricated. Impressions of the dies were made in polyvinylsiloxane material and poured in die stone followed by fabrication of zirconia copings using CAD/CAM technology. A stereomicroscope was used to evaluate the marginal accuracy before and after cementation. For testing fracture resistance, a universal testing machine was used. Results: Comparison of mean values of marginal accuracy before cementation for deep chamfer 11.41 \? 4.61µm and shoulder margin group 51.9 \? 13.1µm and after cementation for deep chamfer 40.38 \? 9.47 µm and shoulder margin groups 77.4 \? 14.3µm were calculated. The data for both the groups was statistically analyzed P< 0.0001. The mean value of fracture resistance for deep chamfer 1874 \? 723N and shoulder margin 1069 \? 288N was calculated, P< 0.005. Conclusion: Hence within the limitations of the study, deep chamfer margin showed better marginal accuracy and fracture resistance than shoulder margin for zirconia copings.

Keywords: Dental ceramics, Deep chamfer, Fracture resistance, Marginal accuracy, Shoulder margin, Zirconia

Full Text:

Introduction

The demand for tooth-colored restorations has surged by multitudes in the last decade.1Although a 94% success rate has been attributed to metal-ceramic restorations2 due to their conservative preparation and satisfactory aesthetics, concerns have been raised regarding their biocompatibility and optical properties.3 On the other hand, properties like biocompatibility, light absorption, light scattering behavior and relative affordability present a significant rationale for the use of all ceramics in dentistry.4 These materials can be defined by their inherent properties that form hard, stiff and brittle materials due to the nature of their inter-atomic bonding which is ionic and covalent.5

The all-ceramic restorations that were initially indicated exclusively in the aesthetic zone, are now also being used in the posterior regions owing to advancements in the material science & fabrication methodology of dental ceramics. Longitudinal clinical studies evaluating glass-ceramic crowns 6,7and those with a densely sintered alumina core8have shown similar results when compared to metal-ceramic crowns, but have shown higher failure rates in the posterior region, where these restorations are prone to brittle fracture.9 However, the use of toughened ceramics such as yttria-stabilized zirconia offers a more fracture-resistant application of all-ceramic crowns in the posterior region without compromising aesthetic qualities.10Zirconia is a crystalline dioxide of zirconium. Its mechanical properties are very similar to those of metals and its colour is like tooth colour.11

Zirconia ceramics have physical properties that can achieve twice the flexural strength and fracture toughness of densely sintered high purity alumina ceramics.11,12 The tetragonal crystals in the yttria-stabilized zirconium oxide ceramics are metastable and can be transformed into larger monoclinic crystals with the application of stress from cracks or flaws.13 This phenomenon is beneficial in hindering the crack growth and increasing fracture toughness; hence, it is referred to as transformation toughening.14

All-ceramic restorations must ensure requirements of fracture strength and precision for marginal accuracy to ensure their clinical success. Increased marginal discrepancies expose the luting agent to the oral environment leading to cement dissolution and microleakage.15 A weak cement seal permits the percolation of bacteria and causes inflammation of the vital pulp.16In-Vivo studies have correlated a large marginal discrepancy with a higher plaque index and compromised periodontal health.17-20

Since the preparation & fabrication of all-ceramic restorations are far more critical & technique sensitive as compared to metal-based restorations, adequate preparation guidelines are of paramount importance to ensure their success. The strength of an all-ceramic restoration depends not only on the fracture resistance of the material but also on a suitable preparation design that provides adequate material thickness.21 The most commonly used margin designs for all-ceramic restorations include chamfer, deep chamfer, chamfer with collar, round end shoulder & shoulder. The purpose of this study was to comparatively evaluate the effect of two margin designs deep chamfer and shoulder on the marginal accuracy & fracture resistance of zirconia core restorations.

Materials and Methods

The study was carried out using two machined standard stainless-steel dies with a height of 7mm and diameter of 5mm.22The marginal area of one machined die was prepared with a deep chamfer (Figure 1A) finish line (1mm depth) while the marginal area of the other die was prepared with a shoulder (Figure 1B) finish line (1mm depth). The convergence of the axial walls was kept at 10o. Four reference lines were scribed at the mid-point of each surface of the die (i.e.mid buccal, -distal, -lingual, -mesial) for evaluating the marginal accuracy. A custom tray for each die was fabricated for making the impression. Orientation grooves were machined on the base of the die to ensure the accurate fit of the custom tray (Figure 1C).Impression of each die was made using polyvinylsiloxane impression material (Dentsply AQUASIL; Monophase). An equal amount of base & catalyst paste was dispensed on a glass slab. Using a cement spatula, the two pastes were manipulated to achieve a uniform colour & consistency, after which it was carried onto the custom tray and an impression was made (Figure 1D and 1E). The impressions were poured in die stone (Kalabhai Ultrarock)following which zirconia copings (CDA ZIRCAM 5AXIS CAD/CAM) of 0.4mm thickness with 35μm cement space23 were fabricated on the stone dies, using CAD/CAM technology (Figure 2).

For evaluation of marginal accuracy before cementation, the fit of each coping was visually examined on the metal die before assessing the marginal accuracy. The marginal fit was evaluated by measuring the gap between the edge of the coping and the prepared steel die margin using a stereomicroscope (Wuzhou New Found Instrument Co. Ltd. China; Model: XTL 3400E) of 30X magnification Figure 3A and 3B. All the measurements were made perpendicular to the steel die axis.24At four different points (mid-buccal, mid-distal, mid-lingual, mid-mesial) the distance between the edge of the coping and the prepared steel die margin was measured using image analysis software.24 Three measurements were made at each of the four positions; a total of 12 measurements per coping was performed. The mean of 12 values indicated the mean marginal accuracy value for each coping.24

Before cementation, all the copings were thoroughly cleaned with distilled water and then air-dried. The copings were then luted to the master metal die with RelyX resin cement (3M ESPE) following the manufacturer’s recommendation. During the cementation procedure, the crowns were placed under the constant pressure of 10N for 1 minute to ensure complete and uniform seating and polymerized with light exposure of 30 seconds per crown.25After removing the excess cement and cleaning the restoration margin, post cementation marginal gap analysis was executed in the same manner as previously described in Figure 3Cand 3D.

For testing the property of fracture resistance, the cemented samples were loaded in distilled water at room temperature for 24hrs to mimic the hydrolytic effect of saliva on the ceramic.14Mechanical testing was done using a Universal Testing Machine26(Star Testing Systems, India Make, Software BasedModel no. MSTS 248). The samples were clamped in the holder of the machine and loaded vertically on the occlusal surface. As the position of the applied force has a significant influence on fracture strength results, the loading piston was positioned at the center of the occlusal surface.23 The load was applied along the long axis of each stainless-steel die with a crosshead speed of 3mm/min until fracture occurred. The fracture load data was automatically recorded using the software (Figure 4 A and B).

Method of data analysis

Statistical analysis was done by descriptive statistics as mean, SD, etc. Comparison of groups was done by applying Student’s ‘t’ test (unpaired) and inter-group comparison by Student’s t-test (paired). The level of significance (P) was calculated using SSPS Version 17.0 Software program.

Results

The following values were obtained for Marginal accuracy (deep chamfer and shoulder) using Image analysis software and fracture resistance (deep chamfer and shoulder) using a Universal testing machine as shown in Table 1 and 2.

For marginal accuracy before cementation, the mean ± SD was 11.41 ± 4.61µm (deep chamfer) and 51.9 ± 13.1 µm (shoulder margin) as shown in Table 3. The marginal accuracy was better in the deep chamfer group as compared to the shoulder group.

The mean ± SD of marginal accuracy after cementation were 40.38 ± 9.47µm (deep chamfer) and 77.4 ± 14.3µm (shoulder margin) as shown in Table 4. The data were analysed for both the groups using a student t-test which showed a statistically significant difference (P<0.0001). The marginal accuracy was better in the deep chamfer group as compared to the shoulder group.

The comparison of marginal accuracy gap before and after cementation in deep chamfer and shoulder group is shown in Figures 5A and 5B. The marginal gap increased in both groups post cementation.

Similarly, fracture resistance for deep chamfer the mean ± SD was 1874 ± 723N and for shoulder margin, the mean ± SD was 1069 ± 288N. The data was analysed using the student’s t-test which showed a statistically significant difference (P <0.005) as shown in Table 5.Chamfer margins showed a better fracture resistance as compared to shoulder margins.

Discussion

Marginal fit & fracture strength are two important criteria for the clinical success & longevity of all-ceramic restorations. During a systematic review of clinical complications in fixed prosthodontics,27 all-ceramic crowns showed an 8% incidence of complications, with crown fractures being the most common. A decrease in strength after thermal and/or mechanical fatigue has been reported for various ceramic materials. Ceramic materials are particularly vulnerable to tensile stresses, and mechanical resistance is also additionally influenced by the presence of superficial flaws and internal voids. Such defects may represent the sites of crack initiation.26 This phenomenon could also be influenced by various factors, like marginal design and thickness of the restoration, residual processing stress, magnitude direction and frequency of the applied load, modulus of elasticity of restoration components, restoration cement interfacial defects and oral environmental effects.28

It is desirable to possess close marginal adaptation to scale back the width of cement lines.  Open marginal configurations encourage microleakage of bacteria and their by-products due to the dissolution of the luting agents. This will cause severe effects on the health of pulpal tissues. The connection between margin adaptation and periodontal health has been confirmed in experimental animals and humans.29 Inaccurate margin adaptations also affect the fracture strength of the ceramic restoration. Hence, there’s a continuing quest to determine the best way to minimize the width of the cement line within accepted technique constraints & increase the fracture strength of all-ceramic restorations.

This study aimed to comparatively evaluate the influence of two margin designs namely- deep chamfer and shoulder on the marginal accuracy and fracture resistance of zirconia core restorations. The metal dies utilized in this study, although not replicating the elastic modulus of teeth, were homogeneous in composition and provided even, void-free support for the ceramic restorations.28 It has been previously stated that since metal dies are obtained by milling processes, they permit for more uniform measurements along any preparation30.31 compared to natural teeth32 or acrylic resin dies.33 The non-uniform nature of the preparations within the natural teeth and acrylic resins incorporate other variables during discrepancy measurements. Thus, the utilization of metal dies aided in the standardization of the study. In the present study, zirconia copings were tested without any veneering material, this is because studies have indicated that marginal gaps of zirconia crowns are within clinically acceptable limits after porcelain veneering34 and that neither the veneering porcelain nor the thickness of the veneering porcelain had a significant effect on the compressive load to failure of bi-layered crowns.28

The marginal accuracy was better with deep chamfer preparation as compared to the shoulder group; with a mean of 11.41µm & 51.9 µm for deep chamfer & shoulder respectively, before cementation and 40.38 µm & 77.4 µm for deep chamfer & shoulder margins, after cementation, respectively. These results were in concurrence with the studies by Jalalian et al.,201126Pera et al.,199435, Att et al.,200936, Bindl et al., 200537 and contrary to the results obtained by Edson et al., 200438and Souza et al., 201239

Gavelis et al., 198140 gave an insight into how the finish lines can affect cementation. The author stated that when the crown is cemented, the axial wall of the preparation approaches the axial wall of the interior crown surface. The escape path for the cement decreases causing the hydrostatic pressure within the crown to increase until it matches the patient’s biting pressure. At this point, the crown fails to seat further. If the cement does not set, it will continue to escape until the particles at the axial walls prevent further seating.40 Certain finish lines like deep chamfer used in this study, apparently facilitated the escape of cement early in the cementation process & thus offered a better seal with decreased width of the cement line.

The student’s t-test revealed a significant difference in the fracture resistance between the two groups, with a deep chamfer margin showing a mean fracture resistance of 1874 N & shoulder margin of 1069 N respectively.

These results are in concurrence with the study carried out by Jalalian et al.,201122,26 wherein the authors suggested that the chamfer margin showed better fracture strength than the shoulder margin because the marginal fit was superior in the former. They suggested that this could be because of a curve in the chamfer finish line that causes a better spread in the load. However, such a condition does not exist in a 90o shoulder margin that has sharp endings. According to their studies, shoulder margin had the worst marginal fit for all-ceramic restorations.

However, the fracture resistance of the two groups is more than biting forces & the marginal gap is within acceptable limits (120 µm). Resin cement is indicated for cementation of all-ceramic crowns; hence we have a strong marginal adaptation of the crowns that enhances the fracture strength. But a statistically significant difference exists between the two groups that revealed the deep chamfer margin has better fracture resistance than the shoulder margin.

Conclusion

The deep chamfer margin showed better marginal accuracy than the shoulder margin for zirconia coping restoration. Deep chamfer margin shows better fracture resistance than shoulder margin for zirconia copings. Both the margin designs showed clinically acceptable values for marginal accuracy (≤120µm). Within the limitations of this study, it can be concluded that preparation margin design influences the marginal accuracy and fracture resistance of all-ceramic restorations.

Acknowledgement

The authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/ editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

Conflict of interest: Nil

Source of funding: Nil

References:

1. Stavridakis MM, Krejci I, Magne P. Immediate dentin sealing of only preparations: the thickness of pre-cured Dentin Bonding Agent and effect of surface cleaning. Oper Dent. 2005 Nov-Dec;30(6):747-57.

2. Walton TR. A 10-year longitudinal study of fixed prosthodontics: clinical characteristics and outcome of single-unit metal-ceramic crowns. Int J Prosthodont.1999 Nov-Dec;12(6):519-26.

3. Sadowsky SJ. An overview of treatment considerations for esthetic restorations: a review of the literature. J Prosthet Dent. 2006 Dec;96(6):433-42.

4. Kelly JR, Campbell SD, Bowen HK. Fracture-surface analysis of dental ceramics. J Prosthet Dent. 1989 Nov;62(5):536-41.

5. McLaren EA, Cao PT. Ceramics in Dentistry—Part I: Classes of Materials. Inside Dentistry 2009 Oct;5(9)94-103.

6. Fradeani M, Redemagni M. An 11-year clinical evaluation of leucite-reinforced glass-ceramic crowns: a retrospective study. Quintessence Int. 2002 Jul-Aug;33(7):503-10.

7. Malament KA, Socransky SS. Survival of Dicor glass-ceramic dental restorations over 14 years: Part I. Survival of Dicor complete coverage restorations and effect of internal surface acid etching, tooth position, gender, and age. J Prosthet Dent. 1999 Jan;81(1):23-32.

8. Odman P, Andersson B. Procera AllCeram crowns followed for 5 to 10.5 years: a prospective clinical study. Int J Prosthodont. 2001 Nov-Dec;14(6):504-9.

9. De Jager N, Pallav P, Feilzer AJ. The influence of design parameters on FEA-determined stress distribution in CAD-CAM produced all-ceramic dental crowns. Dent Mater. 2005 Mar;21(3):242-51.

10. Raigrodski AJ. Contemporary all-ceramic fixed partial dentures: a review. Dent Clin North Am. 2004 Apr;48(2):531-44.

11. Piconi C, Maccauro G. Zirconia as a ceramic biomaterial. Biomaterials 1999 Jan;20(1):1–25.

12. Cales B, Stefani Y, Lilley E. Long-term in vivo and in vitro ageing of a zirconia ceramic used in orthopaedic. J Biomed Mater Res. 1994 May;28(5):619-24.

13. Guazzato M, Albakry M, Ringer SP, Swain MV. Strength, fracture toughness and microstructure of a selection of all-ceramic materials. Part II. Zirconia-based dental ceramic materials. Dent Mater. 2004 Jun;20(5):449-456.

14. Zahran M, El-Mowafy O, Tam L, Watson PA, Finer Y. Fracture strength and fatigue resistance of all-ceramic molar crowns manufactured with CAD/CAM technology. J Prosthodont. 2008 Jul;17(5):370–377.

15. Jacobs MS, Windeler AS. An investigation of dental luting cement solubility as a function of the marginal gap. J ProsthetDent.1991 Mar;65(3):436-42.

16. Goldman M, Laosonthorn P, White RR. Microleakage—full crowns and the dental pulp. J Endod.1992 Oct;18(10):473-5.

17. Valderhaug J, Birkeland JM. Periodontal conditions in patients 5 years following insertion of fixed prostheses. The pocket depth and loss of attachment. J Oral Rehabil.1976 Jul;3(3):237-243.

18. Valderhaug J, Heloe LA. Oral hygiene in a group of supervised patients with fixed prostheses. J Periodontol. 1977 Apr;48(4):221-4.

19. Janenko C, Smales RJ. Anterior crowns and gingival health. Aust Dent J.1979 Aug;24(4):225-30.

20. Silness J. Periodontal conditions in patients treated with dental bridges. 3. The relationship between the location of the crown margin and the periodontal condition. J PeriodontalRes.1970;5(3):225-9.

21. Friedlander LD, Munoz CA, Goodacre CJ, Doyle MG, Moore BK. The effect of tooth preparation design on the breaking strength of Dicor crowns: Part I. Int J Prosthodont.1990 Mar-Apr;3(2):159-68.

22. Jalalian E, Rostami R, Atashkar B. Comparison of chamfer and deep chamfer preparation designs on the fracture resistance of zirconia core restorations. J Dent Res Dent Clin Dent Prospects. 2011;5(2):41-45.

23. Beuer F, Aggstaller H, Edelhoff D, Gernet W. Effect of preparation design on the fracture resistance of zirconia crown copings. Dent Mater J. 2008 May;27(3):362-7.

24. Subasi G, Ozturk N, Inan O, Bozogullari N. Evaluation of marginal fit of two all-ceramic copings with two finish lines. Eur J Dent. 2012;6(2):163-168.

25. Jung RE, Sailer I, Hämmerle CH, Attin T, Schmidlin P. In vitro colour changes of soft tissues caused by restorative materials. Int J Periodontics Restorative Dent. 2007 Jun;27(3):251-7.

26. Jalalian E, Aletaha NS. The effect of two marginal designs (chamfer and shoulder) on the fracture resistance of all-ceramic restorations, Inceram: an in vitro study. J Prosthodont Res. 2011 Apr;55(2):121-5.

27. Goodacre CJ, Bernal G, Rungcharassaeng K, Kan JY. Clinical complications in fixed prosthodontics. J Prosthet Dent. 2003 Jul;90(1):31-41.

28. Webber B, McDonald A, Knowles J. An in vitro study of the compressive load at fracture of Procera AllCeram crowns with varying thickness of veneer porcelain. J Prosthet Dent. 2003 Feb;89(2):154-160.

29. Felton DA, Kanoy BE, Bayne SC, Wirthman GP. Effect of in vivo crown margin discrepancies on periodontal health. J Prosthet Dent. 1991 Mar;65(3):357-64.

30. Lui JL. The effect of firing shrinkage on the marginal fit of porcelain jacket crowns. Br Dent J.1980 Jul 15;149(2):43-5. 

31. Groten M, Axmann D, Pröbster L, Weber H. Determination of the minimum number of marginal gap measurements required for practical in-vitro testing. J Prosthet Dent.2000 Jan;83(1):40-9.

32. Tao J, Han D. The effect of finish line curvature on marginal fit of all-ceramic CAD/CAM crowns and metal-ceramic crowns. Quintessence Int. 2009 Oct;40(9):745-52.

33. Beuer F, Aggstaller H, Richter J, Edelhoff D, Gernet W. Influence of preparation angle on the marginal and internal fit of CAD/CAM-fabricated zirconia crown copings. Quintessence Int. 2009 Mar;40(3):243-50.

34. Vigolo P, Fonzi F. An in vitro evaluation of the fit of zirconium-oxide-based ceramic four-unit fixed partial dentures, generated with three different CAD/CAM systems, before and after porcelain firing cycles and after glaze cycles. J Prosthodont. 2008 Dec;17(8):621-6.

35. Pera P, Gilodi S, Bassi F, Carossa S. In vitro marginal adaptation of alumina porcelain ceramic crowns. J Prosthet Dent. 1994 Dec;72(6):585-90. 

36. Att W, Komine F, Gerds T, Strub JR. Marginal adaptation of three different zirconium dioxide three-unit fixed dental prostheses. J Prosthet Dent. 2009 Apr;101(4):239-47.

37. Bindl A, Mörmann WH. The marginal and internal fit of all-ceramic CAD/CAM crown-copings on chamfer preparations. J Oral Rehabil. 2005 Jun;32(6):441-7.

38.Hilgert E, Buso L, Neisser MP, Bottino MA. Evaluation of marginal adaptation of ceramic crowns depending on the marginal design and the addition of ceramicBrazilian Journal of Oral Sciences. 2004;3(11):619-623. 

39. Souza RO, Özcan M, Pavanelli CA, Buso L, Lombardo GH, Michida SM, Mesquita Am, Bottino MA. Marginal and internal discrepancies related to margin design of ceramic crowns fabricated by a CAD/CAM system. J Prosthodont. 2012 Feb;21(2):94-100.

40. Gavelis JR, Morency JD, Riley ED, Sozio RB. The effect of various finish line preparations on the marginal seal and occlusal seat of full crown preparations. J Prosthet Dent. 1981 Feb;45(2):138-45. 

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A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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