Introduction: The strength of all-ceramic restoration depends not only on the fracture resistance of the material but also on a suitable preparation design that provides adequate material thickness. Objective: The purpose of the study was to evaluate the property of fracture resistance and marginal accuracy of zirconia core restorations with two different margin designs. Methods: Two stainless steel dies, with deep chamfer and shoulder margin designs were fabricated. Impressions of the dies were made in polyvinylsiloxane material and poured in die stone followed by fabrication of zirconia copings using CAD/CAM technology. A stereomicroscope was used to evaluate the marginal accuracy before and after cementation. For testing fracture resistance, a universal testing machine was used. Results: Comparison of mean values of marginal accuracy before cementation for deep chamfer 11.41 __ampersandsignplusmn; 4.61__ampersandsignmicro;m and shoulder margin group 51.9 __ampersandsignplusmn; 13.1__ampersandsignmicro;m and after cementation for deep chamfer 40.38 __ampersandsignplusmn; 9.47 __ampersandsignmicro;m and shoulder margin groups 77.4 __ampersandsignplusmn; 14.3__ampersandsignmicro;m were calculated. The data for both the groups was statistically analyzed P__ampersandsignlt;0.0001. The mean value of fracture resistance for deep chamfer 1874 __ampersandsignplusmn; 723N and shoulder margin 1069 __ampersandsignplusmn; 288N was calculated, P__ampersandsignlt;0.005. Conclusion: Hence within the limitations of the study, deep chamfer margin showed better marginal accuracy and fracture resistance than shoulder margin for zirconia copings.