International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 13 Issue 13, July, 2021

Pages: 184-189

Date of Publication: 05-Jul-2021


Print Article   Download XML  Download PDF

A Cross-Sectional Study on Brain Lesions Diagnosed Through Magnetic Resonance Spectroscopy in Patients from South Kerala

Author: Smitha H, Meena Devi V N, Jacob Vinoo, Sreekanth K S

Category: Healthcare

Abstract:Introduction: A hospital-based study is conducted to find out the frequency, types, and aetiology and gender differences in brain lesions in patients diagnosed through Magnetic Resonance Spectroscopy (MRS) from South Kerala. Objectives: The study aims to assess the socio-demographic characteristics with the increasing incidence of brain lesions in patients attending a tertiary care hospital in South Kerala. Materials and Methods: In this study, there were 81 patients, both males and females, who underwent MRS for the diagnosis of brain lesions and studied for their socio-demographic characteristics which were recorded and compared. Results: The present study revealed that brain lesions were more common in males (57%) as compared to females (43%) (46:35). The frequency of brain lesions was higher in the middle aged group (52%) when compared to the younger age (6%) and old age group (42%). It is found that out of the 81cases, Meningioma is the most common types of brain lesions and also found that the symptoms are well correlating with clinical conditions as indicators for intervention. Conclusion: The analysis of the study indicates the need for special attention of such patients who come with early symptoms suggestive of brain lesions for the correct diagnosis through MRS and for further treatments.

Keywords: Age, Gender, Headache, Meningioma, Magnetic resonance spectroscopy, Vomiting

Full Text:

INTRODUCTION

There is an increasing prevalence of brain lesions in recent years and the underlying diseases associated with lesions are also drastically increasing. In most cases since there are tissue damages involved it is very difficult to treat, however, an early diagnosis may help to lead a quality life with proper treatment and medication.

    In the UK, the annual incidence of brain tumour is approximately 0.06-0.01%. In which 72 % of people with a brain tumour are above the age of 50 years.1The prevalence of the previous history varies depending on location, type of tumour and age of the patient.2 After a head injury at any age, vomiting is another common symptom noticed.3 Another risk factor of brain injury is high and low blood pressure. The incidence of the infarct is higher in patients with high blood pressure.4

     Brain lesions include brain abscess, tuberculoma, neurocysticercosis, tumours and sarcoidosis.5 The studies revealed that per year the incidence of Central Nervous System (CNS) tumours varies from 10-17 per lakh persons for intracranial and 1-2 per lakh persons for intraspinal tumours.6 With the help of newer advanced techniques like Diffusion-weighted  Magnetic Resonance imaging, Perfusion weighted  Magnetic Resonance, Magnetic Resonance Spectroscopy etc, Neoplastic lesions can be distinguished from non-neoplastic lesions.7 Magnetic Resonance Spectroscopy (MRS) is a specialized in vivo technique that is used to differentiate the lesions by distinct patterns for the specific disease process to offer quality treatments.8, 9 To our knowledge literature is scarce regarding history like headache, vomiting, nausea, dizziness etc in patients with a brain lesion. The current study was undertaken to investigate the incidence of brain lesions in patients with characteristic risk factors involved including headache, vomiting, dizziness etc to assess the diagnostic significance.

MATERIALS AND METHODS

This is a retrospective study, conducted in the Radiology Department of one of the major tertiary health care centres in South Kerala. All the patients suspected of brain lesions and who underwent MRS for the diagnosis were included in the study from January 2018 to December 2018. The study was approved by the Institutional Ethics Committee. Only patients with proven MRS diagnosis for brain lesion were included as study subjects. In addition to the types of brain lesions, patient’s demographics including age and gender were also taken for analysis and interpretation. Both males and females were included in the study. Patients with implants, aneurysm clips, pacemakers, heart valves and those who are not willing to participate in the study and patients with age below 20 years were excluded from this study.

 The ethical clearance number is SGMC-IEC NO: /383/11/2018(F)

        The patients were categorised according to the age as patients with 20-40 years, patients with 40-60 years and patients with > 60 years. There were 81 patients, both males and females, who underwent MRS for the diagnosis of brain lesions and studied for their age, gender, types of lesions and history and were recorded to get the distribution and pattern of brain lesions.MRI scans of three different planes- Axial, Coronal and Sagittal were performed by using MRI scans of 1.5 T with sequences like FLAIR T2 weighted imaging and diffusion-weighted imaging (DWI). For analysing the spectra, Spectroscopy-2D Brain software was used.  MRS requires radiofrequency (RF) coils and a software package. For the spectrum acquisition, different spatial localization techniques like Single-voxel and Multi-voxel imaging were used. The Single-voxel technique records spectra from one region of the brain at a time. 10 Multi-voxel technique simultaneously recorded spectra from multiple regions.11    

RESULTS

      The brain tissue concentrations of metabolites (Figure 1) like N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), lactate (Lac), Myo-Inositol (mI) etc and measured as spectral peaks through MRS. A raised Cho or decreased NAA combined with a rise in Cho/Cr and Cho/NAA ratios indicated a tumour. Additionally, lipid and lactate peaks were observed in infections.  The relation between types of lesions and gender are represented in figure 2. From this study it was observed that out of 81 patients analysed for the study, 46 patients (57%) were males and 35 (43%) were females. The present study indicates that brain lesions were more common in males (57%) when compared to females (43%) with a male to female ratio of (46: 35). Figure.3 represents the frequency of brain lesions concerning age. Among these 81 cases, age varied from 20 years to 60 years. It was revealed that the frequency of brain lesions was higher in the middle aged group (52%) when compared to younger age (6%) and old age groups (42%). Patients with age 20-40 years accounted for 5 cases (6%), 40- 60years accounted for 42 cases (52%) and >60  years accounted for 34 cases (42%).

The types of lesion detected by Magnetic Resonance Spectroscopy in these patients are represented in figure 4. It was found that out of the 81 cases, meningioma was the most common types of brain lesions affecting the South Kerala population as diagnosed through MRS. Other types of brain lesions observed were glioma, granuloma, seizure, ophthalmoplegia, cranioplasty, oligodendroglioma, cerebral metastasis, tuberculoma, cavernoma, 6th nerve palsy, subarachnoid haemorrhage (SAH), peripheral vertigo, cerebellopontine angle (CPA) tumour, migraines, macroadenoma, amyotrophic lateral sclerosis, cerebral ischemia, fazeka’s grade II, glioblastoma multiforme, cerebral atrophy, granulomatous, cystic lesion, meningitis, Fazekas's grade I, ethmoid sinusitis, Tolosa hunt syndrome, multiple sclerosis, Rathke's cleft cyst, microadenoma, encephalomalacia, tubercular granuloma, mastoiditis, glomus tympanum.

                       As per the study, it was observed that out of 34 types of brain lesions, meningioma is the most common type of lesion affecting females as compared to males (figure 5). Figure: 6 show the types of lesions in three different age groups of 20-40 years,40-60 years and   > 60 years.  It was observed that meningioma is more common in people age >60 years.

                       The history of other inflammatory diseases and symptoms were represented in figure 7. It was found that out of 81 patients, 39 % had a headache, 30 % had vomiting, 23 % had Type-2 diabetes mellitus and 7% had dizziness. Further, it was observed that in most of the brain lesions the blood pressure was high for the subjects. Based on the clinical examination, the main symptom observed was vomiting in patients with meningioma, glioma, seizure, oligodendroglioma, tuberculoma, CP angle tumour, amyotrophic lateral sclerosis, fazeka’s gradeII, meningitis, Tolosa hunt syndrome, Rathke's cleft cyst, encephalomalacia and tubercular granuloma. Similarly, it was also found that patients suffering from lesions like glioma, seizure, cerebral metastasis, tuberculoma, cavernoma, CP angle tumour, migraines, macroadenoma, cerebral ischemia, fazeka’s grade II were also presented with headache. It was noted that the dizziness was there in patients with CP angle tumour, granulomatous and glomus tympanum. It was also observed that there was a history of type -2 Diabetes mellitus for patients affected with meningioma, cerebral metastasis, tuberculoma, nerve palsy, peripheral vertigo, migrainosus, macroadenoma, cysticlesion, tubercular granuloma and mastoiditis. Another history like hemiparesis was found in lesion granuloma.     

DISCUSSION

Nowadays clinician takes a keen interest in the management of brain lesions due to their high incidence. In this study, we retrospectively analyzed the data regarding incidence, medical history and the symptoms associated with different types of brain lesions presented in patients who attended a major tertiary health care centre in South Kerala over 12 months. This information may help to predict the need for a specific diagnosis to confirm the lesions as early as possible to get better treatment.

 In this study, it was observed that the middle-aged group is more affected with brain lesions unlike in other studies from developed countries. Previous studies indicate that the incidence of brain lesions in developed and developing countries are common in the elderly population.12 In England, about 1.5 % -1.9% of all cancers, Central Nervous System (CNS) tumours are predominant in old age.13 Present study shows that males are more prone to brain lesions as compared to females in South Kerala indicating gender has a major role in disease risk and prognosis. Earlier study it was also found that there is a measurable difference in the prevalence, mortality and progression of cancer in men and women.14  Earlier studies show that there is a higher incidence of CNS tumours in females in the United States compared to England.13 But a study conducted in Asia revealed that brain metastases were more common in males as compared to female.12 Another study also revealed that males are more proponent with seizures compared to females, which were supporting our findings.15

The present study also found that one of the common types of lesions detected is meningioma.  Similarly, it was found to be more in females compared to males. A previous study also revealed that meningioma is asymptomatic and was found that it is the more frequent type of lesion observed in people.16 According to World Health Organization (WHO) meningioma are more common in women.17  Similarly in one of the studies it was mentioned that females are more prone to meningioma than male, in the ratio 2:1.18  It was observed that in developed countries the meningioma is more common in children.13 In another study it was reported that women are more susceptible to develop meningioma than men.18 It was also detected that females are prone to low-grade meningioma while males are more susceptible to malignant type.14 In one of the study conducted in the US it was found that of all primary central nervous system tumours, 37% were of meningioma.  Also, the incidence increases with twice as common in females as in males.19 In our present study it was also found that the meningioma is more in old age group (›60yrs). Previous  studies  revealed   that there is an increase in the incidence of meningioma with the increase in age.20

   This study shows that the lesions like cerebral metastases were presented with headache. In one of the study, it was also found that headache was the presenting symptom in intracranial metastases.21 Present study also shows that for the brain lesions including tumours like meningioma, glioma, tuberculoma, CP angle tumour and other lesions like seizure and cerebral metastasis there was a symptom of vomiting. In this study, it was found that the lesion like glioma, the main history was vomiting and headache.  Earlier studies also confirmed that vomiting is a common symptom after a head injury at any age.3

         In the present study, it was observed that lesion like subdural hematoma was presented with intracranial bleed. The previous study shows that acute subdural hematoma was a reason for intracranial haemorrhage.22 Present study revealed that nerve palsy was associated with diplopia.  Earlier studies revealed that there is a clinical history of uncrossed diplopia associated with eye pain in nerve palsy lesions.23  In this study it was found out that SAH was presented with a history of bleed from the nose and mouth. Studies also found that SAH is associated with ruptured intracranial aneurysms.24  In this study it was observed that peripheral vertigo was presented with a history of nephropathy and retinopathy.  From one of the study, it was concluded that the complications of diabetes like retinopathy and neuropathy may affect the vestibular system .25 

       The current study shows that the lesion including tumours like meningioma, tuberculoma, nerve palsy, peripheral vertigo, migraines, macroadenoma, cystic lesion, tubercular granuloma and mastoiditis were diagnosed with type -2 diabetes mellitus (DM). Earlier studies also reported that DM is a significant risk factor for several types of cancer, including cancer of the breast. In the previous study, it was also found that diabetic individuals had a risk of brain tumours.26 In this study, it was found that individuals with other lesions like cerebral metastasis were also diagnosed with DM. In earlier studies also it was confirmed that DM was a significant predictor in patients treated for brain metastasis.27 

Conclusion

     Meningioma is the most common types of Brain Lesions which are detected through Magnetic Resonance Spectroscopy (MRS) among the old aged group of patients from South Kerala. It is also found that meningioma is predominant in females. This indicates the need for special attention from the clinicians to take care of female patients in the old aged group who comes with early symptoms suggestive of brain lesions and to impart correct diagnosis through Magnetic Resonance Spectroscopy for time management. This may lead to an improved understanding of the mechanisms of advanced diagnostic modalities, better categorization of symptom constructs, and prospective trials for the management of the symptoms in patients with brain lesions.

Acknowledgement

The authors are greatly thankful to the hospital management of   Sree Gokulam Medical College & Research Foundation for their help and support in the patient's study and facility provided. The authors are also thankful to the Department of Physics, Noorul Islam Centre for Higher Education for their technical support for the study.

 Conflict of Interest

All authors declared that they have no conflict of interest and no source of funding.

Authors Contribution

Mrs. H Smitha – First author

Is the principal investigator involved in the study. Done in the design, data acquisition, data analysis and manuscript preparation, manuscript editing and literature search.

Dr. VN Meena Devi – Second author

She is involved in coordinating the work and giving valuable suggestions for modifications as the corresponding author.

Dr. Jacob Vinoo

Provided the patients for the study and helped in the interpretation of the report of MRS.

Dr. K S Sreekanth - Fourth author

Contributed to the preparation of the manuscript. Involved in the data analysis especially for the analysis and interpretation of the biochemical changes in MRS.

References:

1.Kernick D P, Ahmed F, Bahra A, Dowson A, Elrington G, Fontebasso M, et.al. Imaging patients with suspected brain tumour: guidance for primary care. Bri J of Gen Pract. 2008 Dec; 58 (557): 880–885.  DOI: https://doi.org/10.3399/bjgp08X376203

2.Kirby S, Purdy R A . Headache and brain tumours. Curr Neurol Neurosci Rep . 2007  April; 7(2):110-116.DOI : https://doi.org/10.1007/s11910-007-0005-7

3. Borland ML, Dalziel SR, Phillips N, Dalton S, Lyttle MD, Bressan S ,et al . Vomiting With Head Trauma and Risk of Traumatic Brain Injury. Paedia. 2018 Apr;141(4): 1 -12. doi: 10.1542/peds.2017-3123.

4.Jain V, Choudhary J, Pandit R. Blood Pressure Target in Acute Brain Injury. Indian J Crit Care Med. 2019 Jun;23(Suppl 2): S136-S139. doi:10.5005/jp-journals-10071-23191

5.Sharma V, Prabhash K, Noronha V, Tandon N, Joshi A. A systematic approach to the diagnosis of cystic brain lesions. South Asian J Cancer. 2013 Apr; 2(2):98-101. doi: 10.4103/2278-330X.110509.

6.Acharya S, Azad S, Kishore S, Kumar R, Arora P. Squash Smear Cytology, CNS Lesions – Strengths and Limitations. Nat J Lab Med. 2016 Jul; 5(3): PO01-PO07. DOI: 10.7860/NJLM/2016/18686.2125

 7.Garg R, Sinha M.Multiple ring-enhancing lesions of the brain, J Postgraduate Med 2010Oct;56(4):307-316. https://www.jpgmonline.com/text.asp ?2010/56/4/307/70939

 8.Salih M, Yousef M, Abukonna A, Elnour A, Elamin A. Evaluation of Brain Lesions Using MagneticResonanceSpectroscopy. J Am Med Res. 2016Sep;18(2):1-6 https://doi.org/10.9734/BJMMR/2016/28984

9.Cecil K M. Proton magnetic resonance spectroscopy technique for the neurologist .Neuroim Clin N Am. 2013 Jan: ; 23 (3) : 381-392 . doi:10.1016/j.nic.2012.10.003

10.Bertholdo D, Watcharakorn A, Castillo M. Brain proton magnetic resonance spectroscopy: introduction and overview. Neuroimaging Clin N Am. 2013 Aug;23(3):359-80. doi: 10.1016/j.nic.2012.10.002.

11.Horská A, Barker PB. Imaging of brain tumours: MR spectroscopy and metabolic imaging. Neuroimaging Clin N Am. 2010 Aug; 20(3):293-310. doi: 10.1016/j.nic.2010.04.003.

12.Saha A, Ghosh SK, Roy C, Choudhury KB, Chakrabarty B, Sarkar R. Demographic and clinical profile of patients with brain metastases: A retrospective study. Asian J Neurosurg. 2013 Jul; 8(3):157-61. doi: 10.4103/1793-5482.121688.

13.Arora RS, Alston RD, Eden TO, Estlin EJ, Moran A, Birch JM. Age-incidence patterns of primary CNS tumours in children, adolescents, and adults in England. Neuro Oncol. 2009; 11(4):403-413. doi:10.1215/15228517-2008-097

14. Sun T, Plutynski A, Ward S, Rubin JB. An integrative view on sex differences in brain tumours. Cell Mol Life Sci. 2015 Sep;72(17):3323-42. doi: 10.1007/s00018-015-1930-2.

15.Rudresh K, Krishna M V, Sebastian K J . Clinical and Aetiological Profile of Ring-enhancing Lesions on CT Brain. Journal, Indian Academy of Clinical Medicine journal.2008 April; 9(2):100-102.

 16. Shaikh N, Dixit K, Raizer J. Recent advances in managing/understanding meningioma F1000Res. Clin Cancer Res.  2018 Apr; 490(7): 1-8. DOI: 10.12688/f1000research.13674.1

17.Asgharian B, Chen YJ, Patronas NJ, Peghini PL, Reynolds JC, Vortmeyer A, et. al. Meningiomas may be a component tumour of multiple endocrine neoplasia type 1. Clin Cancer Res. 2004 Feb 1;10(3):869-80. DOI : 10.1158/1078-0432.

18. Shah S, Gonsai R N, Makwana R. Histopathological Study of Meningioma in Civil Hospital, Ahmedabad. Int J Cur Res Rev. 2013 Feb ; 05 (03) 76-82 .

 19.Fogh SE, Johnson DR, Barker FG, Brastianos P K, Clarke JL, Kaufmann TJ,et al . Case-BasedReview:meningioma.NeurooncolPract.2016Jun;3(2):120-134.doi: 10.1093/nop/npv063.

20.Wiemels J, Wrensch M, Claus EB. Epidemiology and aetiology of meningioma. J Neurooncol. 2010 Sep; 99(3):307-14. doi: 10.1007/s11060-010-0386-3.  

21.Kaul D, Budach V, Graaf L, Gollrad J, Badakhshi H. Outcome of Elderly Patients with Meningioma after Image-Guided Stereotactic Radiotherapy: A Study of 100 Cases. Biomed Res Int. 2015 May 2015: 1-6. doi: 10.1155/2015/868401.

22.Christiaans MH, Kelder JC, Arnoldus EP, Tijssen CC. Prediction of intracranial metastases in cancer patients with headache. Cancer. 2002 Apr 1;94(7):2063-8. doi: 10.1002/cncr.10379.

23.Patel PV, FitzMaurice E, Nandigam RN, Auluck P, Viswanathan A, Goldstein JN, et al. Association of subdural hematoma with increased mortality in lobar intracerebral haemorrhage. Arch Neurol. 2009 Jan;66(1):79-84. doi: 10.1001/archneur.66.1.79.

24 Hussaindeen, J. R., Mani, R., Rakshit, A., Ramasubramanian, S., Vittal Praveen, S.  Natural history of idiopathic abducens nerve paresis in a young adult. J Opt. 2016 Feb: 9(4), 264–268. https://doi.org/10.1016/j.optom.2016.02.002

25.Nomani, A. Z., Rajput, H. M., Iqbal, M., Jan, Z., Irshad, M., Badshah, M, et al.  Subarachnoid hemorrhage secondary to forceful sneeze. Case Rep Neur Med. 2015 Dec; 1-5. https://doi.org/10.1155/2015/896732.

26..D'Silva LJ, Lin J, Staecker H, Whitney SL, Kluding PM. Impact of Diabetic Complications on Balance and Falls: Contribution of the Vestibular System. Phys Ther. 2016 Mar; 96(3):400-9. https:// doi: 10.2522/ptj.20140604.

27.Tong JJ, Tao H, Hui OT, Jian, C.  Diabetes mellitus and risk of brain tumors: A meta-analysis. Expt Therap Med. 2019; 4(5), 877–882. https://doi.org/10.3892/etm.2012.698

28. LeCompte MC, McTyre ER, Strowd RE, Lanier C, Soike MH, Hughes RT, et al. Impact of diabetes mellitus on outcomes in patients with brain metastasis treated with stereotactic radiosurgery. J Radiosurg SBRT. 2018; 5(4):285-291. PMID: 30538889; PMCID: PMC6255719.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2022 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions