International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 13 Issue 13, July, 2021

Pages: 13-17

Date of Publication: 05-Jul-2021


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Evaluation of Impact Strength of Silver Nano-Particles Reinforced Heat-Activated Polymethylmethacrylate (Pmma) Resin at Various Proportions

Author: Suganya S, Ahila SC, MuthuKumar B, Vasantha Kumar M

Category: Healthcare

Abstract:Introduction: Impact strength of denture base resin is an important factor for making a durable dental prosthesis. Reinforcement with nanoparticles improves the performance of any kind of medical and dental prosthesis. Purpose: To evaluate and compare the impact strength of heat-activated polymethylmethacrylate resin reinforced with Silver nanoparticles in the ratio of 4:1, 3:1, 2:1 to the weight of denture base resin. Materials and Method: According to the ISO 1570, the die was made with a dimension of 55x10x10 mm with a 'V' shaped notch in the centre. The die was duplicated with putty material and the wax patterns were made in baseplate wax and poured into the mould. Then the synthesis of silver nanoparticles was done by reduction method and incorporated into the heat-activated polymethyl methacrylate (PMMA) resin in the ratio of 0:1 4:1, 3:1, 2:1 (Group A (control), Group B, Group C, and Group D) to the weight of denture base resin. The samples were polymerized at a temperature of 74\?C for 8 hours. Then the impact strength was calculated with Charpy's tester. Comparison of impact strength within the group was done using one way ANOVA. Results: On comparing the impact strength of conventional heat-activated PMMA resin with PMMA resin reinforced with silver nanoparticles at 4:1,3;1,2;1 showed the significant value P < 0.001, hence the result is 99.9% statistically significant. Conclusion: The impact strength of heat-activated polymethylmethacrylate resin reinforced with silver nanoparticle in the ratio of 4:1,3;1,2;1 was more than the conventional heat-activated PMMA resin.

Keywords: Impact strength; Polymethyl methacrylate resin; Silver nanoparticle

Full Text:

INTRODUCTION

       Removable dental prosthesis is most widely utilized to replace missing teeth in dental applications.1 Polymethyl methacrylate (PMMA) is the commonly used material to fabricate denture base by heat-curing technique since the 1940s.2 Polymethacrylate (PMMA) resins have dominated the denture base market since their introduction in 1937.3 It satisfies most of the requirements of denture base materials in terms of good esthetics, ease of processing and separability, reasonable cost, etc. However, it has relatively poor resistance to impact and flexural forces that may affect denture design and life span.4

       Most dentures fractures are caused by the combination of fatigue and impact failure, whereas for mandibular dentures, 80% of fractures are caused by impact and involves very high repair costs worldwide.5 Ahmed and Ebrahim 6 found that nearly 70% of dentures had broken within the first 3 years of their delivery.

       Impact failures usually occur out of the mouth as a result of a sudden blow to the denture or by accidental dropping.7The PMMA has a low modulus of elasticity, low impact strength, and low flexural strength but it has many characteristics,8 made it used as denture base material such as ease in processing, stability in the oral environment, lightweight, excellent aesthetic properties, low cost, low water absorption, and can easily recharge and repaired its shape.9,10

      Recent researches showed that the physical and mechanical properties of denture base materials were improved by the addition of fillers to PMMA resin material fibres like polyethene, aramid, carbon and Kevlar were used for reinforcement of denture base resin. But the carbon and Kevlar fibres gave a black tint to the denture base resin which will affect the esthetics of the denture.8

       With the advent of nanotechnology, silver nanoparticles have been synthesised and have been shown potent antimicrobial properties. Silver nanoparticles have been shown unique interaction with bacteria, fungi. They are smaller in size hence they possess physical, chemical and biological properties distinction from bulky material. The smaller particle with a larger surface area provides potent antibacterial action at a lower filler level and avoiding negative influence on mechanical properties. Although the literature related to silver nanocomposites reported with antimicrobial application in the medical field,11 very few studies about the addition of silver particles to denture base resins have been published. Hence this study was done to evaluate and compare the impact strength of heat-activated polymethylmethacrylate resin reinforced with Silver (Ag) nanoparticles in the ratio of 4:1, 3:1, 2:1 to the weight of denture base resin. A hypothesis was formulated that the impact strength of silver nanoparticles reinforced heat polymerized  PMMA resin would be similar to conventional denture base resin.

MATERIALS AND METHOD

Preparation of silver nanoparticles

      For the synthesis of silver nanoparticles chemical reduction method was followed in which the silver nanoparticles were prepared by dissolving 2.52 g of silver nitrate (Merck Specialities Pvt Ltd, India) in 15 mL of deionised water to get a solution of 1 mole. Then 2.23 g of sodium borohydride (Sisco Laboratories Pvt Ltd, India) mixed in 30 mL of deionised with a magnetic stirrer to get a solution of 2 moles in a conical flask. Then the silver nitrate solution is transferred to a burette and then allowed to drop slowly into sodium borohydride solution in a conical flask and mixed with a magnetic stirrer to prevent agglomeration. The temperature around the conical flask was controlled by placing ice cubes. As the stirring process continues, the agglomerates of silver nanoparticles start forming. Then the agglomerates of silver nanoparticles were washed with deionized water, centrifuged, and dried in an incubator at 65°C overnight. It is then ground with a mortar and pestle.

Sample preparation

        According to the ISO 1570, a metal die was made with a dimension of 55x10x10mm with a ‘V’ shaped notch in the centre. The notch is 2mm deep and at an angle of 45° to the horizontal plane. Polyvinylsiloxane (Aquasil, Dentsply, India) putty was used as duplicating material to create a mould space for the fabrication of wax patterns. Baseplate wax (Hindustan modelling wax, India) was used for fabricating the wax pattern.

       A total number of forty wax patterns (Figure.1) were thus made for the preparation of heat-cured acrylic resin samples with silver nanoparticles for evaluating the impact strength.  Heat cure acrylic denture base (Dental Products of India) was chosen as the material for fabricating the samples. The synthetic nanoparticle which was made earlier was mixed with the heat-activated polymer in the ratio of 4:1, 3:1, 2:1 was considered as a control- no nanoparticles (Group A), Group B, Group C, and Group D to the weight of denture base resin with a mortar and pestle. (Table.1)

           For the packing of resin, a compression moulding technique was followed. The hydraulic press (Silfradent, India) was used at 1500 Psi to apply pressure for 3 hours. The curing cycle followed was a long curing cycle and hence the entire flask with the packed material was polymerized at a temperature of 74°C for 8 hours (Delta poly bath, India).

       The fabricated samples are then evaluated for impact strength under Charpy tester (Izod digital Charpy impact tester, Blue star India). (Figure.2) Then the samples were analysed under Scanning Electron Microscope (Phenom X, Phenom-World B V, Netherland) for the distribution of silver nanoparticles. (Figure 3, 4 and 5)

Statistical analysis used

            The impact strength values were statistically analyzed using SPSS version 22.0 (Armonk, NY: IBM Corp). Power analysis was done to establish the sample size at a 99.9% confidence interval. Comparisons within the group were done using One way ANOVA.

RESULTS

        The mean, standard deviation and standard error of impact strength of  Group A, Group B, Group C, and Group D. were  0.9910 ± 0.02424, 1.4590 ±0.03725, 1.5330 ±0.01889, 1.9900 ± 0.01826 J/mm respectively. (Table2) showed the P-value  <0.001, hence the impact strength silver nanoparticles reinforced heat-activated PMMA resin showed 99.9% significant impact strength compared to the control group. (Table 3) Graph.1represents the impact strength values obtained with the control group and silver nanoparticles in the ratio of 4;1, 3:1, 2:1 to PMMA resin.

DISCUSSION

        PMMA resin has been used as a denture base material for more than 70 years. The properties that have contributed the most to the success are excellent appearance, simple processing and easy repair.12 Besides its favourable characteristics, this material has relatively poor mechanical properties such as low toughness and fatigue resistance, to be used as denture bases resulting in repeated fractures requiring repair.13 The Charpy type test selected for the present study has been used by investigators to evaluate the impact strength of denture base acrylic resins.14-17

       The reinforcement of ZrO2 nanoparticles with heat-cure denture base resin decreased the impact strength of the resin but increased the dimensional accuracy and fit of the denture base.18According to a study conducted by Abdulkareem and Hatim,19 its was concluded that samples prepared from PMMA resin is a biocompatible material and silver nanoparticles exhibited the good level of compatibility.

        In this study, the mean values of impact strength of control group A were 0.9910±0.02424 J/mm, for group B 1.4590±0.03725 J/mm, for group C 1.5330±0.01889 J/mm and 1.9900 ±0.01826J/mm for group D. On comparison of the mean values between the control and other groups showed a significant p-value < 0.001 and hence the result was 99.9% significant.

Synthetically prepared nanoparticle forms non agglomerated discrete particles that are likely to penetrate molecules of polymers getting themselves distributed homogenously in the resin molecular chain to produce nanocomposites. Interpretation of the chemistry of this reaction has shown that the silver nanoparticles influenced the formation of the molecular chain by its penetration and bonding molecules thereby increasing the molecular weight of polymers. The corresponding increased values could also be due to decreased ability of the polymer to flow during chain reactions from manipulating to the processing stage. Further increased strength also occurs due to alteration of relaxation behaviour generated by nano-agglomerates of silver nanoparticles incorporated into the polymer matrix. This reaction is responsible for the effects of intermolecular forms affecting the chain stiffness resulting in higher impact strength of acrylic resin.

       The limitations of the study are that the distribution of silver nanoparticles in PMMA resin was uncertain and also it affects the esthetics due to its colour hence, could be used only for the palatal and the lingual contours.

CONCLUSION

       Within the limitations of the study, the authors concluded the impact strength of heat-activated polymethylmethacrylate resin reinforced with silver nanoparticle in the ratio of 4:1,3:1,2:1 by weight was found to be 1.45 J/mm, 1.53 J/mm and1.99 J/mm, which was statistically significant compared to conventional heat-activated polymethylmethacrylate resin. Hence the impact strength of heat polymerized denture base resin was increased by the addition of silver nanoparticles.

Acknowledgement: Nil

Financial support: Nil

Conflicts of interest: The authors declared that there is no conflict of interest.

References:

1.Jancar J, Hynstova K, Pavelka V.Toughening of denture base resin with short deformable fibres.Comp Sci Technol.2009;69:457-62.

2.Fernanda CPPS, Heitor P, Vieira A, Garcia LFR, Consani S.Impact and fracture resistance of an experimental acrylic polymer with elastomer in different proportions. Mater Res. 2009;12:415-18.

3.Hargreaves AS.polymethylmethacrylate as a denture base material in service. J Oral Rehabil. 1975;2:97-104.

4.O’Brien WJ.Dental materials and their selection. 2nd ed. Chicago (IL).Quintessence Pub.1997; 5:85-86.

5.Hari PA, Kalavathy DS, Mohammed HS. Effect of glass fibre and silane treated glass fibre reinforcement on the impact strength of maxillary complete denture. Ann Essences dent. 2011;3:7-12.

6.Ahmed MA, Ebrahim MI.Effect of zirconium oxide nanofillers addition on the flexural strength, fracture toughness, and hardness of heat-polymerized acrylic resin.World J Nano Sci Eng. 2014;4:50-57.

7.Gupta A, Tewari RK.Evaluation and comparison of transverse and impact strength of different high strength denture base resins.Indian J Dent Res. 2016;27:61-65.

8.Vojdani, M,Khaledi AAR.Transverse strength of reinforced denture base resin with metal wire and E glass fibres. J Dent Teh Univer Med Sci. 2006;3:159-166.

9.Engelmeier RL.The history and development of posterior denture teeth-introduction, part II: Artificial tooth development in America through the nineteenth century.J Prosthodont. 2003;12:288-301.

10.Rama KA, Suresh S, Venkata RA, Kishore G, Nagaraj U. Influence of Fiber Reinforcement on the Properties of Denture Base Resins. J Biomat Nanobiotech. 2012;4:91-7.

11.Correa JM,Morie M,Sanches HL,Da Cruz AD,Poiate E Jr,Poiate IA.Silver nanoparticles in dental biomaterials.Int J Biomater. 2015;1:1-9

 12.Furno F et al.Silvernanoparticles and polymeric medical devices: a new approach to prevention of infection. J Antimicrob Chemother. 2004;54:1019-24.

12.Schreiber CK.Polymethylmethacrylate reinforced with carbon fibers.Br Dent J. 1971;130:29-30.

13. Phoenix RD.Denture base materials.Dent Clin North Am. 1996,40;113-120.

14.Dogan OM,Bolayir G,Keskin S, Dogan A, Bek B, Boztug A.The effect of esthetic fibres on the impact resistance of a conventional heat-cured denture base resin.Dent Mat J. 2007;26:232-239.

15.Memon MS,Yunus N,Razak AA.Some mechanical properties of a highly cross-linked, microwave-polymerized, injection-moulded denture base polymer.Int J Prosthodont. 2001;14:214-18.

16.Straioto FG,Ricomini Filho AP, Fernandes Neto AJ,Del Bel Cury AA. Polytetrafluorethylene added to acrylic resins: mechanical properties. Braz Dent J. 2010;21:55-59.

17.Giampaolo ET, Pavarina AC.Effect of reline material and denture base surface treatment on the impact strength of a denture base acrylic resin.Gerodontology. 2010;27:62-69.

18.Begum SS, Ajay R, Devaki V, Divya K, Balu K, Kumar PA. Impact strength and dimensional accuracy of heat-cure denture base resin reinforced with ZrO2 nanoparticles: An in vitro study. J Pharm Biol Sci. 2019;11:S365-70.

 19.Abdulkareem MM, HatimNA.Evaluation of the biological effect of adding aluminium oxide, silver nanoparticles into microwave treated PMMA powder.Int J En Res Sc Tech Eng . 2015;4:172-78.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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