Introduction: Impact strength of denture base resin is an important factor for making a durable dental prosthesis. Reinforcement with nanoparticles improves the performance of any kind of medical and dental prosthesis. Purpose: To evaluate and compare the impact strength of heat-activated polymethylmethacrylate resin reinforced with Silver nanoparticles in the ratio of 4:1, 3:1, 2:1 to the weight of denture base resin. Materials and Method: According to the ISO 1570, the die was made with a dimension of 55x10x10 mm with a __ampersandsignlsquo;V__ampersandsignrsquo; shaped notch in the centre. The die was duplicated with putty material and the wax patterns were made in baseplate wax and poured into the mould. Then the synthesis of silver nanoparticles was done by reduction method and incorporated into the heat-activated polymethyl methacrylate (PMMA) resin in the ratio of 0:1 4:1, 3:1, 2:1 (Group A (control), Group B, Group C, and Group D) to the weight of denture base resin. The samples were polymerized at a temperature of 74__ampersandsigndeg;C for 8 hours. Then the impact strength was calculated with Charpy__ampersandsignrsquo;s tester. Comparison of impact strength within the group was done using one way ANOVA. Results: On comparing the impact strength of conventional heat-activated PMMA resin with PMMA resin reinforced with silver nanoparticles at 4:1,3;1,2;1 showed the significant value P __ampersandsignlt;0.001, hence the result is 99.9% statistically significant. Conclusion: The impact strength of heat-activated polymethylmethacrylate resin reinforced with silver nanoparticle in the ratio of 4:1,3;1,2;1 was more than the conventional heat-activated PMMA resin.