International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 13 Issue 07, April, 2021

Pages: 04-08

Date of Publication: 12-Apr-2021


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Antiprostatic Activity of Ferulene in Male Rats

Author: Tukhtasheva Visola Farmonovna, Rejepov Jumadilla, Djakhangirov Farkhod Nabievich, Zakhidova Lola Tishaevna, Halilov Ravshanjon Muratjanovich, Saidkhodjayeva Dilfuza Mir-Taxirovna

Category: Healthcare

Abstract:Introduction: Studied the antiprostatic activity of the sum of esters of sequiterpine alcohols obtained by ferula thin-braided (ferule). Objective: The purpose of the study was to substantiate the feasibility of using the developed new drug ferulene as a means of antiprostatic action in the body. Methods: To assess the effect of ferulene on androgen-dependent organs, the drug was administered to male rats orally using a metal probe at doses of 1-5-10 mg/kg for 10 days. Each dose of the drug was tested on 10 rats. Results: It was found that ferule has a pronounced ant prostatic effect when administered orally, reduces the mass of adrenogenesis-dependent organs (ventral prostate, coagulating gland, seminal vesicles, and testes) and reduces the level of testosterone in the blood. In terms of ant prostatic activity, ferule is not inferior to surgical castration. Conclusion: Long-term use of ferulene is well tolerated by experimental animals and does not have a toxic effect on the part of biochemical parameters, a decrease in the mass of androgen-dependent organs (ventral prostate, coagulating gland, seminal vesicles, testes) and a decrease in the content of testosterone in the blood associated with the specific activity of the drug about target organs.

Keywords: Ferula finely dissected, Ferula tenuisecta, Esters of sequiterpine alcohols, Ferulen, Prostate, Chronic toxicity

Full Text:

INTRODUCTION

Prostate cancer (PC) is currently one of the most pressing diseases in urology oncology. Survival outcomes for patients with hormonal treatment are different. PC is a fairly common disease. On average, 71 cases per 100 thousand men are registered per year. Moreover, in the last decade, there has been an increase in the incidence of 3% annually. This is an alarming signal that suggests an increase in the number of registered cases by almost 2 times already by 2030. Treatment of patients with prostate cancer is an important task of modern urology due to the prevalence of the disease and the unresolved issues of its therapy. Drug therapy occupies an important place in the treatment of patients with prostate cancer and is based on the results of the latest research on the pathogenesis of this disease. For the drug treatment of patients with prostate cancer, 5-α-reductase inhibitors, α1-adrenergic receptor blockers, polyene antibiotics, antiandrogens, estrogens, and preparations of plant and biological origin are used.1,2

Prostate cancer is one of the most common diseases of men of elderly and senile age, occupying the 2-3rd place in the structure of oncological diseases of the male population and showing a clear tendency to an increase in frequency.3,4

The main functions of the gland are the partial production of semen (about 30% of the total volume), as well as participation in the process of ejaculation. A man's ability to retain urine is also related to prostate function.5,6 Because of the above, the creation of a new agent for the treatment of adenoma and prostate cancer is a scientific novelty and an urgent task.

Based on the esters of ferutinin (C22H30O4), ferutin (C23H32O5), tenuferin (C23H32O6), tenuferidine (C22H30O5) and fertidine (C27H36O4) isolated from the roots of the finely dissected ferula (Ferula tenuisecta celery), a new family has been created. the drug "Ferulen" for the treatment of adenoma and prostate cancer.3

Technology has been developed for the preparation of ferulene, which consists in the extraction of plant materials with alcohol, thickening of the alcohol extract, dilution with water and extraction of esters with ethyl acetate, treatment with 5% potash solution, extraction of esters with 1% KOH solution, acidification with sulfuric acid, extraction with ethyl acetate, evaporation of ethyl acetate solution, chromatographic purification of esters on a column of silica gel (eluent - ethyl acetate-hexane 1: 3) and drying of the esters by adding microcrystalline cellulose. The yield of the ferulene substance is 18.6% by weight of the raw material, esters - 80% of the content in the raw material.4,7 The purpose of the study was to substantiate the feasibility of using the developed new drug ferulene as a means of antiprostatic action in the body.

?ATERIALS AND METHODS

Animals and habitat

All animals were kept in stationary vivarium conditions on a regular diet with free access to water. Experiments with them were carried out by the rules adopted by the International Convention for the Protection of Vertebrate Animals used for Experimental Purposes.6,8

Experimantal design

To assess the effect of ferulene on androgen-dependent organs, the drug was administered to male rats orally using a metal probe at doses of 1-5-10 mg/kg for 10 days. Each dose of the drug was tested on 10 rats. The control group of animals under similar experimental conditions was injected with a solvent (distilled water with the addition of apricot gum). After the end of the experiment, all experimental and control animals were decapitated, the weight of the ventral prostate, coagulating gland, seminal vesicles and testes was determined; the content of testosterone in the blood serum was determined by the radiomunal method on the counter "Gamma-12" with kits for the in vitro radioimmunoassay and the immunoenzyme (Human GmbH (Germany) kit "Diagnostiksistema", Russia) by the method for the determination of testosterone in the blood serum of the Czech company "JMMUNOTECH as" Content of bioactive luteinizing hormone in the blood plasma of male rats was determined using the enzyme immunoassay analyzer MINDRAY-MR-96A. (the work was carried out at the Research Institute of Endocrinology, Ministry of Health of the Republic of Uzbekistan), histological studies were also carried out.

The study of the effect of ferulene on androgen-dependent organs in comparison with surgical castration was carried out on white male rats weighing 300-320 g. the drug was administered orally using a metal probe at a dose of 10 mg/kg for 10 days. Surgical castration (orchiectomy) was performed with a longitudinal incision at the base of the scrotum, the skin and testicular membrane were dissected to the albuminous. The testicle with the epididymis and part of the spermatic cord was bluntly isolated. The rope was clamped in parts with a clamp and crossed. The proximal part of the transected cord was sutured with strong ligatures and the testicle and cord were removed. The control group of animals was injected with a solvent under similar experimental conditions. After the end of the experiment, all experimental and control animals were decapitated, the weight of the ventral prostate, coagulating gland, seminal vesicles and testes was determined; determined the content of luteinizing hormone and testosterone in the blood serum.3,4

The study of the chronic toxicity of the drug Ferulen was carried out in experiments on 40 white outbred rats - males. The drug was injected into the stomach daily at doses of 10-25-50 mg/kg for 2 months. Each dose was tested in 10 rats. The control group of animals was injected with the solvent under similar conditions. All experimental and control animals were kept in the same conditions and on the usual diet.

Statistical analysis

The digital material obtained during the experiments was statistically processed using the Student's t-test.

RESULTS AND DISCUSSION

The results of the studies showed that oral administration of ferulene at a dose of 1 mg/kg reduced the weight of the ventral prostate, coagulating gland, seminal vesicles and testicles compared with the control group of rats by 35%, 26.2%, 34% and 11%, respectively. With an increase in the dose of the drug to 5 mg/kg, ferulene reduced the mass of these organs by 56%, 39%, 41% and 23%, respectively. A further increase in the dose of ferulene to 10 mg/kg reduced the mass of the ventral prostate and the coagulating gland to values close to post-castration and compared with the control group, the mass of the ventral prostate decreased by 73%, the coagulating gland by 61%, seminal vesicles by 60% and testes by 41% (Table 1).

The results of the studies carried out to assess the content of luteinizing hormone and testosterone in the blood serum showed that ferulene with 10 days of oral administration in doses of 1-5-10 mg/kg leads to a decrease in testosterone, compared with control animals by 19%, 28% and 54 % of a luteinizing hormone by 24.5%, 31% and 47.13%, respectively (Table 2).

The results of a histological study showed that the introduction of ferulene at a dose of 1 mg/kg caused in some animals a slight decrease in the amount of secretion in the lumen of the prostate, a decrease in the height of epithelial cells and an increase in the connective tissue of the organ. In other animals, the reaction to the introduction of ferulene at a dose of 1 mg/kg was significantly stronger.

When the dose of ferulene was increased to 5 mg/kg, the histological changes became permanent and deeper. The size of the lumens of the end sections of the gland decreased, even more, the volume of the cytoplasm of epithelial cells, their shape changed, they became low-cylindrical or cubic. Desquamation of the epithelium from a large area of the alveoli was observed. The connective tissue grew, replacing the atrophied secretory parts of the gland. The cells of the basal layer of the glandular epithelium had a pycnotic nucleus and an optically transparent cytoplasm. Hypertrophy and hyperplasia of myocytes around the secretory glands were observed.4,7-9

With a further increase in the dose of ferulene to 10 mg/kg against the background of hyperplasia of connective tissue and muscle elements, pronounced dystrophic and destructive changes in the secretory epithelium were observed.

Thus, the results of the studies carried out have established that, depending on the administered dose, ferulene, to varying degrees, reduces the mass of androgen-dependent organs, causes dystrophic destructive changes in the prostate and reduces the content of luteinizing hormone and testosterone in the blood serum of male rats (Table 1 and 2).

The results of the studies on the effect on the mass of androgen-dependent organs in comparison with orchiectomy are presented in Table 3. As can be seen from the table, ferulene at a dose of 10 mg/kg reduced the mass of the ventral prostate and coagulating gland at the level of surgical castration, and compared with the control animals, the mass of the ventral prostate decreased by 67%, the coagulating gland by 66%, seminal vesicles by 59%. and testicles by 35% (Tables 3, 4 and 5).

The results of the studies have shown that long-term oral administration of ferulene at doses of 10-25-50 mg/kg is well tolerated by experimental animals. All experimental animals did not differ from control rats in general condition, in haematological parameters (Tables 6 and 7).

The results of the studies have shown that long-term oral administration of ferulene at doses of 10-25-50 mg/kg is well tolerated by experimental animals. All experimental animals did not differ from the control rats in general condition, behaviour, and haematological parameters (Table 6 and7). On the part of biochemical parameters, a decrease in urea was noted, b- lipoproteins, cholesterol and lipids (Table 5)

CONCLUSION

The studies carried out in this work showed that ferulene has a pronounced antiprostatic effect when administered orally, reduces the mass of adrenogenesis-dependent organs (ventral prostate, coagulating gland, seminal vesicles, testes) and reduces the level of testosterone in the blood. In terms of antiprostatic activity, ferulene is not inferior to surgical castration. When applied again, it does not accumulate. Long-term use of ferulene is well tolerated by experimental animals and does not have a toxic effect on the part of biochemical parameters, a decrease in the mass of androgen-dependent organs (ventral prostate, coagulating gland, seminal vesicles, testes) and a decrease in the content of testosterone in the blood associated with the specific activity of the drug concerning target organs.

Conflict of Interest: None

Source of Funding: None

References:

  1. Huggins C, Hodges CV. Studies on prostatic cancer: I. The effect of castration, estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 2019;1(19):293-297.

  2. Tukhtasheva VF, Rejepov J, Djakhangirov FN, Azamatov AA, Zakhidova LT. Preclinical study of safeness of the drug ferulen. Am J Med Sci Pharm Res 2020;2(6):134-143.

  3. Guryeva MV, Yu. B,  Kotov VA.  Daily monitoring of blood pressure and heart rate in the diagnosis. Russ Bull Obstet Gynecol 2013;3:4-9.

  4. Wu YW, Colford Jr JM. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA 2000;284(11):1417-142

  5. Fox R, Kitt J, Leeson P, Aye C, Lewandowski AJ. Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact on the Offspring. J Clin Med 2019;8(10):162

  6. Vasiliev V, Tyagunova  AV, Drozheva VV. Renal function and indicators of endogenous intoxication with gestosis.  Obstet Gynaecol 2013; 4:16-20.

  7. Mallick S. Study on the clinical profile of patients with cerebral palsy (Doctoral dissertation) 2011; 52(172):127-4

  8. Tukhtasheva VF, Rejepov J, Djakhangirov FN, Azamatov AA, Amonov MA. Study on the antiandrogen activity of ferulen in the experiment. Eur Appl Sci 2018;1:30-32.

  9. Garg, SA, Chakravarti R, Singh NR, Masthi RC, Goyal GR. Jammy E. Dengue serotype-specific Seroprevalence among 5- to 10-Year-Old Children in India: A Community-Based Cross-Sectional Study. Int J Infer Dis 2017;54:25–30.

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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