International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - vol 08 issue 08, April, 2016

Pages: 44-49

Date of Publication: 20-Apr-2016


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INTRAOPERATIVE AND POSTOPERATIVE COMPLICATIONS, ACCIDENTS AND FAILURES RELATED WITH DENTAL IMPLANT APPLICATIONS

Author: Damla Torul, Mehmet Cihan Bereket, Ismail Sener, Ali Ilker Bastan

Category: Healthcare

Abstract:With revolutions in biotechnology, implant surgery has become a routine therapy in the last three decades for the rehabilitation of completely or partially edentulous patients. Despite implant surgery increasing popularity and high success rates of, complications due to implant therapy are still unavoidable. Complications can occur either intra-operative or post-operative period of the surgery. Intra-operative complications such as hematoma and ingestion or inhalation of mechanical components or instruments can be serious as life-threatening. Other complications that occur during implant placements are usually associated with local damages such as nerve injury, adjacent teeth damage and perforations of the nasal cavity or maxillary sinus. Also mandible fractures, sinusitis, peri-implant mucositis, peri-implantitis and periapical implant lesions are the complications that frequently encountered after surgery. Therefore implant therapy is a complicated procedure and the management of the complications associated with this therapy requires a special training and experience. This review categorized complications associated with dental implant applications and discusses management options of these complications.

Keywords: Dental implant, Displacement, Hemorrhage, Life-threating, Nerve injury

Full Text:

INTRODUCTION Dental implants are appliances placed in the jawbones for the management of tooth loss to maintain adequate function and aesthetic [1].Since dental implants have been first introduced in 1970s, they are used in various areas of the mouth with an increasing success rate and popularity[2,3].In 2003, Ardekian et al. [4] reported the 5-year success rate of implants range between 93 % and 97 %.However, complications in implant surgery are frequently encountered and management of these complications are become an important issue [5-7]. Until recently, these implant-related complications have increased by the increase in the number of implants placed and dentists, not only specialist, placing implants [2]. This article examined implant complications in two parts. The first section focuses on intraoperative complications and the second segment addresses the post-operative complications of the implant therapy.

INTRAOPERATIVE COMPLICATIONS Intraoperative complications occur during surgeries and could either be life threatening or local damage triggering. Hemorrhage Hemorrhages can occur during any kind of surgery and they can be taken care of by simple local measures. However, excessive and long lasting hemorrhage is generally considered to be a complication, while it is rarely as serious as life threatening [4,8]. Severe hemorrhages can be associated with the incision of arteries, sinus-lift procedures and preparation of the implant hole [5].The facial and maxillary arteries and their branches are mainly provided the blood supply of the mandible [6].During surgery these arteries may be injured because of the perforation of cortical plates and may leads hemorrhagic accidents [6].Bleeding can be result with a “pseudo-Ludwig phenomenon” which is characterized by elevation of the tongue, elevation of the floor of the mouth and airway obstruction[9]. In maxilla the posterior superior alveolar, infraorbital, descending palatinal and posterior palatin arteries can be damaged during placement of implant or sinus lift procedures [5,6]. Bleeding which arise from the branch of the maxillary artery has been described previously [10,11]. In the presence of hemorrhage, treatment techniques include bone wax, compression, electrocoagulation, bone grafts and in severe cases ligation of the damaged vessels [5,7,8].

It is not recommended to aspirate the area because of its limiting effect on the tamponading effect of the blood clot. In the cases which have restricted visibility external carotid angiography and endovascular management may be necessary [9]. In severe cases airway control can be provided by nasotracheal intubationand cricothyroidotomyor tracheostomy [11]. To prevent this kind of complication, detailed preoperative evaluation and rigorous surgery should be provided. Also, preoperative CT scans and usage of short implants in the risk areas decreases the prevalence of this complication(Figure 1) [4,7,12].

Involuntary Ingestion or Inhalation of Mechanical Components or Instruments During intraoperative period of surgery, a slippery area shows up due to blood and saliva. Hence, the instruments or implant components can slip and fall into the mouth accidentally from the operator’s hand [8].In these accidents, instruments can aspirated or ingested in 13 % and 87 % of the cases respectively [13].Also, sharpness of the instruments may cause vital structure injuries[13]. Therefore, a life threatening complication may occur when these materials are ingested or inhaled by the patient [7,8]. When the instrument is in the gastrointestinal tract the first management options are radiographic examination and a fiber-rich diet [13]. If, a foreign object is aspirated, airway embarrassment can occur and this is a potentially life-threatening condition. Thus, the patient airway must provide immediately and the foreign object should remove as quick as possible [5,14]. Also, bronchoscopy or gastroscopy are useful to reduce the morbidity [13].

To prevent this complication, gauze throat screens and silk ligatures can be used during surgery[5,14]. Nerve injury Neurosensory disturbances are unpleasant experiences that occur as a result of poor flap design, direct mechanical damage to nerve, compression of intra-alveolar edema or hematoma, excessive preparation during implant placement, nerve repositioning and implant placement in atrophic mandible [4,5,7,8]. These disturbances are classified in increasing severity as neuropraxia, axonotmesis and neurotmesis, respectively. Generally these injuries are temporary and continue as 4 weeks to 10 months [7]. Within this period, patients with such injuries may have difficulties performing common activities due to paresthesia, anesthesia dysesthesia or hyperesthesia [7,15]. Commonly inferior alveolar nerve, the mental nerve, the incisor branch of the mandibular nerve, the lingual nerve, and the nasopalatine nerve are likely to be exposed to iatrogenic injury during implant placement procedures [8]. To prevent the nerve injury the preoperative evaluation and exact localization of anatomic structures in the implantation area are mandatory. CBCT and CT scans are the techniques of choice for locate the anatomic structures [6,7,16].

When nerve injury occur as a result of pressure originate from an implant, management options include the removal of the implant or placement of a short implant. In the cases of minor injuries spontaneous healing can observed within days or months. However, prolonged pressure and neuritis may result with permanent degeneration of the nerve [17]. The primary treatment of nerve injuries include neuronal anti-inflammatory drugs or vitamin B-complex, but if a persistent anesthesia or dysesthesia is present more specialized procedures such as microsurgery may be required [5,17]. Damage to Adjacent Teeth Adjacent tooth damage is a rare complication of implant surgery and generally occurs with single implant placements [4,8].Tooth damage can be associated with inadequate distance between the implant and adjacent tooth, wrong angulation of the implant or occurrence of excessive heat during surgery [18].

As a result of above mentioned factors total or partial vitality loss can be seen in the adjacent tooth. Patients are generally asymptomatic but pain or sensitivity may occur occasionally [8]. To prevent the damage of adjacent tooth, a minimum distance of 1,5 to 2mm should be provided between adjacent tooth and the implant [6,7].Also, pre-surgical computed tomography may help ensure accurate diagnosis [18].In the presence of this complication, root-canal treatment, apicectomy and extraction are among the available treatment options(Figure 2) [6]. Perforations of Nasal Cavity or Maxillary Sinus Placement of implants in maxilla close to the nasal cavity or maxillary sinus may result with the perforation of the maxillary sinus or the nasal floor [5-8,19]. Management of perforations of the sinus membrane is commonly provided with the placement of biomaterials [6,19]. Other methods for treating perforation are folding the membrane up against itself, using sutures and fibrin glue[19].However, in the presence of large perforations surgery must postpone during the healing process [7,8]. Several investigators mentioned that these complications are generally well-tolerated and didn’t affect the implant survival [4,5,7].

Displacement of the Implant Inside the Sinus or Nasal Cavity Insertion of implant several millimeters into the sinus or nasal cavity is well tolerated [7]. However, displacement of the implant inside the sinus or nasal cavity is a serious complication [8]. This may be caused by inadequate primer stability, suction effect and improper distribution of occlusal forces [6]. Also, thin maxillary bone, inadequate planning and lack of experience are contribute the movement of the implants in the maxillary sinuses and nasal cavities [20]. In the case of a dislocated implant, it must remove surgically by intraoral or transnasal approach to prevent further complications [6,8]. To prevent these complications knowledge of anatomy, correct pre-surgical planning and adequate post-surgical follow up is mandatory(Figure 3) [6].

EARLY POSTOPERATIVE COMPLICATIONS Mandible Fractures The most important risk factor for the mandible fractures is the placement of an implant in the severely atrophic mandible. Also, lateralization of inferior alveolar nerve increases the risk of the fracture [4,6,7]. The compression stress during these surgical procedures and the prepared osteotomy sites weakens bones and leads to pathologic fractures [4]. The reported prevalence of this complication is 0,2% in the edentulous mandible [21]. Fractures of the mandible associated with implant placement can occur either immediately or in the post-operative period of the surgery [22]. To avoid such complications, Parkand Wang [17] mentioned that atrophic mandible must have a minimum of 7 mm height and 6 mm width. The management of this complication is related with severity of the fracture, volume of the mandibular bone and the location of the implant [5,7].

Open reduction or conservative approaches with bone grafts can used for the fixation of the fractured mandible [22]. Flap Dehiscence Dehiscence can be defined as the surgical wound opening that result with the exposure of the dental implant [8].Coverscrew loosening, mechanical irritation and flap tension are among the contributing factors of this complication [17]. The reported incidence of this complication vary between 2% and 13% [6].In the presence of small dehiscence, granulation tissue can compensate the opening but if the dehiscence is large re-suturing of the area should be performed [8].

Emphysema Emphysema is a complication which is caused by the high intraoral pressure and it is rarely encountered [7,8]. Air originate from the surgical devices or materials can be forced into the surgical area and the emphysema will occur [7]. Clinically it presents with swelling of half of the face and patients complained of pain similar to the tension sensation [23]. A characteristic crackling sound is evinced upon palpation [8,23]. Massage and compression are the therapeutical measures to manage emphysema by accelerating resorbtion of the air trapped in the tissues [8].

LATE POSTOPERATIVE COMPLICATIONS Failed Osseointegration Impaired healing, occlusal loading during osseointegration, failure to follow the planned protocol, technical errors during surgery, infections and especially bone overheating during implant site preparation leads failures in osteointegration. Lack of osseointegration is results in loss of the implant [8,24].Failure of endosseous implants can occur before or after occlusal loading with a prosthetic superstructure. The reported failure rate is from 0,7% to 3,8% [25]. Infections Maxillary Sinusitis Posterior maxilla is a complicated area for implant placement, so sinus lifting and grafting procedures are usually used to overcome the limitations of this area. However, complications include sinusitis and infection can unavoidably occur as a result of these procedures [26]. Symptoms of sinusitis may include fever, facial pain, and yellow to green purulent discharge from the nose, which may drain posteriorly causing a cough and malaise [7]. Management of implant associated sinusitis is surgical and maintaining the drainage and ventilation are the purposes of this procedure [20].

Peri-Implant Mucositis Peri-implant mucositis is defined as the reversible inflammation of the mucosa adjacent to the implant and may be caused by inadequate prosthetic restorations, poor oral hygiene and improper abutments or healing caps [4,27,28]. Generally no signs of bone losses are observed in this situation [4]. Reddish color of the inflamed mucosa adjacent to implant, swelling and bleeding are the clinical features of the periimplant mucositis[28]. Mechanical, antiseptic and antibiotic treatments are possible procedures of choice for controlling an ongoing infection (Figure 4)[28].

Peri-Implantitis Peri-implantitis is an inflammatuar process around tissues of an implant and it results with the loose of the bone around the implant [29,30]. It is an important cause of implant failures and accounts for 10% to 50% of all failures observed one year after the implantation [1]. Early implant exposure, poor oral hygiene are the risk factors contributing peri-implantitis [4]. Diagnosis of peri-implantitis is based on degree of supporting boneloss, clinically detectable pocket depths, purulent discharge and implant mobility [28]. Management of peri-implantitis depend on the severity of the cases and include debridement, antimicrobial treatment or regenerative procedures [1,30].

Periapical Implant Lesions The symptoms of apical peri-implantitis is pain, swelling, tenderness and occasionally the presence of a fistula [31]. Possible causes of this complication are excessive heating, contamination, vascular ischemia and pre-existing bone pathology [4,31,32]. Removal of granulation tissue, curettage of the bony walls and if the primary stability is absent scarification of the implant are the treatment options [32]. Implant Fractures Implant fracture is a biomechanical complication with the reported incidence of 0,2 % in totally edentulous and 1,5 % in the partially edentulous jaws. The lack of periodontal ligament is an important risk factor for this complication and hinder the compensation against the forces that occur at the time of chewing [33].

Also bone loss, manufacturing defects, excessive occlusal load and patients-related habits are the other possible causes of the implant fractures [30]. To overcome these shortcomings, periodic occlusal evaluation and proper preoperative planning by considering biomechanical principles are essential. Removal of the implant, modification of the existing prosthesis or modification of the fractured implant are the options for management of this condition (Figure 5) [34].

CONCLUSION Nowadays, there is no doubt that implant therapy has become the most predictable treatment option for rehabilitation of tooth loss. However, complications related with implant therapy are inevitable events that effect the success of the entire therapy. To reduce the incidence of these complications knowledge of surgical anatomy, careful clinical and radiographic examination, proper treatment planning, usage of appropriate instruments and rigorous surgery are important prerequisites. If all of these factors are carefully followed, the complications are effectively avoided. But, adequate training and experience are required when these complications occur.

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9. Del Castillo-Pardo de Vera JL, Lopez-Arcas Calleja JM, Burgueno-Garcia M. Hematoma of the floor of the mouth and airway obstruction during mandibular dental implant placement: a case report. Oral Maxillofac Surg 2008;12(4):223-6.

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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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