International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - 12(18), September, 2020

Pages: 42-47

Date of Publication: 22-Sep-2020


Print Article   Download XML  Download PDF

Evaluation of Anxiogenic Effect of Pseudoephedrine in Albino mice

Author: Srinivasa Rao Konijeti, Kadiri Sunil Kumar, Sri Leela Movva, Muralikrishna K. S.

Category: Healthcare

Abstract:Objectives: The study was designed with the rationale to investigate the anxiety-like behaviour with pseudoephedrine treatment in albino mice. Numerous reports of case studies suggest that pseudoephedrine treatment triggers anxiety symptoms in patients. Methods: Pseudoephedrine at doses 2 mg/kg and 5 mg/kg p.o was tested for its anxiogenic effect in albino mice by using elevated plus maze (EPM) and elevated zero mazes (EZM) models. Control and test group mice were treated with distilled water and pseudoephedrine for 15 days. The anxiogenic assessment was done on 15th day one hour after pretreatment with distilled water and pseudoephedrine. Results: In EPM study, there is a significant reduction in the number of entries (1.8 \? 0.63 with 5 mg/kg and 2.8 \? 1.39 with 2 mg/kg) and time spent in open arm (5.8 \? 0.47 seconds with 5mg/kg and 8.0 \? 1.98 seconds with 2mg/kg) with pseudoephedrine treatment at both doses when compared to control-treated mice (Number of entries=3.2 \?1.78 and time spent in open arm= 12 \? 0.14 seconds). In EZM there is a significant decrease in the number of entries in open arm (1.4 \? 0.21) and time spent in open arm (4.4 \? 1.72 seconds) with pseudoephedrine 5 mg/kg treatment when compared to control mice (Number of entries= 2.6 \? 1.35 and time spent in open arm= 11.6 \? 1.26 seconds). Conclusions: The reduction in the tendency of the mice to enter into the open arm after pseudoephedrine treatment indicates anxiety. This indicates that pseudoephedrine has an anxiety-inducing property.

Keywords: Pseudoephedrine, Anxiogenic, Elevated plus maze, Elevated zero maze, Open arm, Number of entries.

Full Text:

INTRODUCTION

Anxiety disorders are a group of conditions set apart by outrageous or obsessive uneasiness or dread.1 Anxiety disorders can meddle with an individual's work, family and public activity. They will in general be constant and can be impairing. Despite their across the board commonness, anxiety issues have not gotten a similar acknowledgement as other significant conditions, for example, mood and psychotic disorders, also, the primary care doctor is typically the central assessor and treatment provider.2,3  In any case, anxiety turns into an issue when it interferes with typical capacities, is irrelevant to a genuine danger, causes physical side effects and gets excruciating to the individual.4 Pseudoephedrine is a sympathomimetic drug beneficial and widely used in nasal congestion problems during the common cold.5 The psychotropic impact of pseudoephedrine is notable since their broad use by belligerents on all sides of the Second World War, is one of stimulation with increased aggression and higher fatigue threshold.6 There are several reports which indicate that continuous treatment with pseudoephedrine can lead to cardiovascular, neurological, anxiogenic and mood-related issues.7,8,9 However there are no preclinical studies till date regarding the anxiogenic effect of pseudoephedrine treatment. Therefore the present study was planned to explore the anxiety-like behaviour induced by pseudoephedrine treatment in albino mice by using widely accepted anxiety models such as elevated plus maze and elevated zero mazes.  

MATERIALS AND METHODS

  For the present study, a pure sample of pseudoephedrine was purchased from Chandra Laboratories, Hyderabad. Pseudoephedrine was suspended in 0.5% w/v acacia and the suspension of pseudoephedrine was utilized for acute toxicity and in vivo anxiety study.

Experimental animals

Albino mice (20-25g) were used for the anxiogenic evaluation. They were procured from Sainath agencies, Musheerabad, Hyderabad (282/99/CPCSEA). After randomization into various groups and before initiation of the experiment, the rats were acclimatized for 10 days.  Animals were housed in polypropylene cages and maintained under standard environmental conditions such as temperature (26±2°C), relative humidity (45-55%) and 12 hr. dark/light cycle. The animals were fed with mice/rodent pellet diet (Golden Mohur Lipton India Ltd) and water ad libtum. The research was carried out in the experimentation room of animal husbandry of Marri Laxman Reddy Institute of Pharmacy, Dundigal, Hyderabad. The study protocol was approved from the Institutional Animal Ethics Committee (IAEC) before the commencement of the experiment (1567/PO/Re/S/11/ CPCSEA)

Determination of Acute Toxicity (OECD Guidelines 423)10

 Pseudoephedrine was studied for single-dose oral acute toxicity study at a dose of 5 mg/kg, 50 mg/kg, 300 mg/kg and 2000 mg/kg p.o in albino mice (6 mice in each group) by following the guidelines of OECD 423.  All the mice were observed for toxicity signs for 24 hrs followed by 14 days. On 8th day and 14th-day body weights of mice were recorded.

Evaluation of Anxiogenic activity of Pseudoephedrine in albino mice11

Control and test mice were treated with 0.5% acacia and pseudoephedrine suspension 1 hour before the evaluation of anxiogenic effect.

Elevated Plus Maze

The EPM mechanical assembly comprises two crossing arms that frame the state of a '+'. Two contradicting shut arms are built with high dividers and are frequently named alleys. The converging open arms are a similar width and length as the closed arms, yet need sides to make a raised, thin strolling surface. Mazes can be built of the scope of materials, including wood or shaded Plexiglas, or metal. The size of the maze changes by species, research facility and producer. A common rodent maze raised roughly 70cm over the floor, with each arm estimating 10cm wide by 45cm long with the dividers of the encased arms around 30cm high. For mice, the device is downsized with arms that are around 5 cm wide by 30cm long, the side nooks 15cm high, and the whole contraption raised roughly 30cm over the floor. The walking surface might be secured with elastic or fixed with ledged on the external edges of the open arms to improve footing. All the animals were also subjected to elevated plus-maze assessment of anxiety levels. Every rodent was set separately in the focal point of the maze looking towards the open arm and coming up next were recorded a) time spent in open arm.  b) Number of entries in the open arm during 5 minutes session.12  

  Elevated Zero Maze

All the animals were investigated for anxiety levels by employing elevated zero mazes set up.  This test is the pharmacological validated assay of anxiety in animal models that is based on the natural aversion of mice to EZM. It is composed of a 6 cm wide range ring with outer diameter of 45cm containing four equal quadrants of alternating walled or installed sections. The entire ring is elevated to a height of 20 cm from the floor. Control and Pseudoephedrine treated mice were placed in the walled region at the start of 5 minutes session and the number of entries and time spent in the open arm by individual mice were recorded during these 5 minutes.13

Statistical Methods

The values are demonstrated as mean ± S.E.M and measurable noteworthiness among treated and control group was analyzed utilizing One way ANOVA, trailed by Dunnett's test where ***P<0.001, **P<0.01 and *P<0.05 was considered statistically significant.

RESULTS

Acute toxicity study

Pseudoephedrine was found to be toxic orally at 50 mg/kg which is evident by the death of all the mice at 50 mg/kg. At 5 mg/kg the mice were found to be healthy and exhibited no clinical signs and symptoms of toxicity even after 14 days. Hence 5 mg/kg (higher dose) and 2 mg/kg (lower dose) were considered as therapeutically safer doses for the Pharmacological studies.

Elevated plus Maze apparatus (EPM)

The results obtained from EPM indicates the anxiety-inducing potential of Pseudoephedrine (Anxiogenic effect) when treated in albino mice with both higher and lower doses for 15 days. In Pseudoephedrine treated group it was found that Number of entries in open arm (higher dose= 1.8±0.63, Lower dose= 2.8±1.39) is significantly less when compared to control-treated mice (Number of entries in open arm= 3.2±1.78). The time spent in open arm in Pseudoephedrine treated mice (higher dose= 5.8 ± 0.47sec, Lower dose= 8.0±1.98 sec) is significantly less when compared to Control mice (time spent in open arm = 12±0.14 sec). This reduction in the number of entries in open arm and time spent in open arm in Pseudoephedrine treated mice when compared to control mice indicates induction of anxiety with Pseudoephedrine. The results are shown in tables 1, 2 and 3 and displayed in Figure 3 and 4.

Elevated zero Maze apparatus (EZM)

 In EZM apparatus, it was found that Pseudoephedrine treated mice exhibited a significant reduction in the number of entries in open arm (higher dose= 1.4±0.21 and lower dose = 2.2±0.59) and time spent in open arm (higher dose= 4.4±1.72 seconds and lower dose = 7.8±0.43 seconds) when compared to the control group mice (number of entries in open arm = 2.6±1.35 and time spent in open arm = 11.6±1.25 seconds). This indicates that the Pseudoephedrine treated mice have a fear for the open areas and have more tendencies towards the closed arm. Hence Pseudoephedrine at both doses has produced anxiety in albino mice on treatment for 15 days.  The results are depicted in Table 5, 6 7 and 8 and figure 5 and 6.

 

DISCUSSION

Cough and cold remedies comprise a major portion of the OTC market. An excessive dose of a nasal decongestant Sympathomimetic is reported to cause bipolar disorder in a 13-year-old girl.14 Several case reports are describing the anxiogenic symptoms with Pseudoephedrine such as restlessness, irritability and insomnia.15,16 The participation of 9 of 74 children in a clinical trial of Pseudoephedrine has to be terminated because of severe side effects such as dizziness, irritability, nightmares and general malaise.17 Few countries have banned Pseudoephedrine due to its undesirable effects on CNS. However, it is widely used in India as an effective nasal decongestant. There are no preclinical or clinical reports to substantiate the anxiogenic potentials of Pseudoephedrine. Therefore the current study was planned to evaluate the anxiogenic effect of Pseudoephedrine in mice by using EPM and EZM models. Pretreatment with Pseudoephedrine for 15 days has shown a significant decrease in the number of entries in open arm and time spent in the open arm when compared to control mice. This shows that Pseudoephedrine can induce anxiety in albino mice. There is no precise mechanism to correlate Pseudoephedrine with anxiety but it can be hypothesized that Pseudoephedrine as a mixed acting sympathomimetic can trigger anxiety symptoms by directly acting on adrenergic receptors or by increasing the availability of norepinephrine or epinephrine to stimulate adrenergic receptors. Pseudoephedrine may also enhance glutamate levels which result in anxiety-like symptoms.

CONCLUSIONS:

Neuropsychiatric adverse effects such as sedation, bipolar disorder, psychosis, disturbed sleep and memory impairment have been linked to medications used in the treatment of asthma and allergic rhinitis. One such OTC marketed drug which on long term use is reported to cause anxiety-like behaviour is Pseudoephedrine. Therefore by employing standard anxiety-based animal models such as EPM and EZM in the present study to evaluate the effect of Pseudoephedrine on anxiety in albino mice. Based on the results of the present study we conclude that Pseudoephedrine (5 mg/kg and 2 mg/kg) treatment for 15 days exhibited significant anxiety in albino mice in EPM and EZM models. There is a significant reduction in the number of entries in open arm and time spent in open arm with Pseudoephedrine treatment at both doses. However further biochemical and histopathological studies are required to establish the exact neurochemical mechanism behind the induction of anxiety with Pseudoephedrine.

ACKNOWLEDGEMENT

The authors are grateful to the management of Marri Laxman Reddy Institute of Pharmacy, Hyderabad for providing the facilities for our research.

SOURCE OF FUNDING

No Funding

CONFLICT OF INTERESTS

This is to inform you that the authors declare that they have no conflict of interest regarding this article. 

References:

Frye CA, Walf AA, Rhodes ME, Harney JP. Progesterone enhances motor, anxiolytic, analgesic, and anti-depressive behaviour of wild-type mice, but not those deficient in type 1 5α-reductase. Brain research. 2004 Apr 9;1004(1-2):116-24.

2. Roy-Byrne PP, Craske MG, Stein MB, et al. A randomized effectiveness trial of cognitive-behavioural therapy and medication for primary care panic disorder. Arch Gen Psychiatry. 2005;62(3):290–298.

3.  Stein MB, Sherbourne MG, Craske MG, et al. Quality of care for primary care patients with anxiety disorders. Am J Psychiatry. 2004;161(12):2230–2237.

4.  Qiu A, Tuan TA, Ong ML, Li Y, Chen H, Rifkin-Graboi A, Broekman BF, Kwek K, Saw SM, Chong YS, Gluckman PD. COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology. American Journal of Psychiatry. 2015 Feb 1;172(2):163-72.

5. Lockey RF. Rhinitis medicamentosa and the stuffy nose. Journal of allergy and clinical immunology. 2006 Nov 1;118(5):1017-8.

6.  Mortuaire G, De Gabory L, François M, Massé G, Bloch F, Brion N, Jankowski R, Serrano E. Rebound congestion and rhinitis medicamentosa: nasal decongestants in clinical practice. A critical review of the literature by a medical panel. European annals of otorhinolaryngology, head and neck diseases. 2013 Jun 1;130(3):137-44.

7.   Laccourreye O, Werner A, Giroud JP, Couloigner V, Bonfils P, Bondon-Guitton E. Benefits, limits and danger of ephedrine and pseudoephedrine as nasal decongestants. European Annals of Otorhinolaryngology, Head and Neck Diseases. 2015 Feb 1;132(1):31-4.

8. Mucha SM, Detineo M, Naclerio RM, Baroody FM. Comparison of montelukast and pseudoephedrine in the treatment of allergic rhinitis. Archives of Otolaryngology-Head and Neck Surgery. 2006 Feb 1;132(2):164-72.

9.  Kanfer I, Dowse R, Vuma V. Pharmacokinetics of oral decongestants. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 1993 Nov 12;13(6P2):116S-28S.

10. P'ng XW, Akowuah GA, Chin JH. Acute oral toxicity study of Clinacanthus nutans in mice. International journal of pharmaceutical sciences and research. 2012 Nov 1;3(11):4202.

11.  Kulkarni, Shrinivas K., Kulwinder Singh, and Mahendra Bishnoi. "Comparative behavioural profile of newer antianxiety drugs on different mazes." September 2008 Vol. 46 (4): 633-638.

12. Emamghoreishi M, Khasaki M, Aazam MF. Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze. Journal of ethnopharmacology. 2005 Jan 15;96(3):365-70.

13. Matto V, Harro J, Allikmets L. The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in the rat. Neuropharmacology. 1997 Mar 1;36(3):389-96.

14. Dalton R. Mixed bipolar disorder precipitated by pseudoephedrine hydrochloride. South Med J 1990;83:64-5.

15. Erickson CH, McLeod RL, Mingo GG, Egan RW, Pedersen OF, Hey JA. Comparative oral and topical decongestant effects of phenylpropanolamine and d-pseudoephedrine. American journal of rhinology. 2001 Mar;15(2):83-90.

16. Bender B, Milgrom H. Neuropsychiatric effects of medications for allergic diseases. Journal of allergy and clinical immunology. 1995 Feb 1;95(2):523-8.

 17. Bain D. Can the clinical course of acute otitis media be modified by systemic decongestant or antihistamine treatment? Br Med J 1983;287:654-6.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2024 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions