Objectives: The study was designed with the rationale to investigate the anxiety-like behaviour with pseudoephedrine treatment in albino mice. Numerous reports of case studies suggest that pseudoephedrine treatment triggers anxiety symptoms in patients. Methods: Pseudoephedrine at doses 2 mg/kg and 5 mg/kg p.o was tested for its anxiogenic effect in albino mice by using elevated plus maze (EPM) and elevated zero mazes (EZM) models. Control and test group mice were treated with distilled water and pseudoephedrine for 15 days. The anxiogenic assessment was done on 15th day one hour after pretreatment with distilled water and pseudoephedrine. Results: In EPM study, there is a significant reduction in the number of entries (1.8 __ampersandsignplusmn; 0.63 with 5 mg/kg and 2.8 __ampersandsignplusmn; 1.39 with 2 mg/kg) and time spent in open arm (5.8 __ampersandsignplusmn; 0.47 seconds with 5mg/kg and 8.0 __ampersandsignplusmn; 1.98 seconds with 2mg/kg) with pseudoephedrine treatment at both doses when compared to control-treated mice (Number of entries=3.2 __ampersandsignplusmn;1.78 and time spent in open arm= 12 __ampersandsignplusmn; 0.14 seconds). In EZM there is a significant decrease in the number of entries in open arm (1.4 __ampersandsignplusmn; 0.21) and time spent in open arm (4.4 __ampersandsignplusmn; 1.72 seconds) with pseudoephedrine 5 mg/kg treatment when compared to control mice (Number of entries= 2.6 __ampersandsignplusmn; 1.35 and time spent in open arm= 11.6 __ampersandsignplusmn; 1.26 seconds). Conclusions: The reduction in the tendency of the mice to enter into the open arm after pseudoephedrine treatment indicates anxiety. This indicates that pseudoephedrine has an anxiety-inducing property.