International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 01 Issue 01, September, 2009

Pages: 16-22

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INFLUENCE OF BENZENE EXTRACT OF PIPER BETEL ON DELAYED SMALL INTESTINAL TRANSIT BY
CHLORPROMAZINE INVOLVING CALCIUM INNERVATIONS IN MICE

Author: Bairagi G.B., Hatkar A.D., Zaferuddin S.D., Dhaked P.S., Tembhurne S.V., Sakarkar D.M

Category: Healthcare

Abstract:Piper Betel Popularly known as 'Pan' in India belongs to family Piperaceae. Medicinally it has stimulant, antiseptic, sialogogue activity. It is reported that calcium is involved in the initiation of contraction of smooth muscle. It increase intestinal motility through L-Type. Chlorpromazine blocks the calcium channel on smooth muscle and relaxes by attenuating intestinal motility. The present study was to evaluate the influence of benzene extract of Piper betel (BEPB) on small intestinal motility (SIT). The study was also undertaken to evaluate the mechanism involve in SIT. BEPB (400 and 800 mg/kg p.o) administered to 15 hrs fasted Swiss albino mice. 4% charcoal meal was administered (10 ml/kg p.o) 1hr after the drug administration and after 20 min all animals were dissected for determination of SIT. For exploration of calcium channel in gastrointestinal motility chlorpromazine (5mg/kg p. o.) was administer 30 min prior administration of drug respectively. The results of study indicate that BEPB accelerate the intestinal transit in normal mice. At 800mg/kg dose it was found to accelerate the transit by 89.5% compared to normal mice which was significant at (P < 0.05) compared to vehicle group. Chlorpromazine inhibits GI transit by 28.85% in normal mice. In presence of BEPB it able to reverse the effect ofchlorpromazine, while the significant effect was observed only at 800mg/kg BEPB. In presence of BEPB chlorpromazine could able to produce upto15.85% inhibitions of SIT which was comparable to standard Metaclopramide (10mg/kg p.o) indicates BEPB could partly produce acceleration effect through calcium involvement as well as by some other pathway as chlorpromazine could not completely inhibit the acceleratory effect of Piper betel on small intestinal transit.

Keywords: Piper betel, Intestinal transit, Chlorpromazine, Calcium channel.

Full Text:

INTRODUCTION Gastrointestinal dysmotility impacts on the quality of life of patients for example, a significant percentage of patients with diabetes have gastrointestinal dysmotility. Gastrointestinal complications of diabetes can affect one or more parts of the gut and produce nausea, vomiting, abdominal pain, constipation and/or diarrhea. Abnormal gastric emptying, or gastroparesis, may lead to poor glucose control and complications of diabetes 1, 2, 3 . The gastrointestinal tract is in a continuous state of contraction, relaxation and secretion. These functions are controlled by neurohumoral systems, which in turn are regulated by various receptor systems, such as cholinergic, adrenergic, serotonergic, opioidergic and calcium channels. Many drugs affect GI transit by acting as agonists or antagonists at specific cellular receptors, such as cholinergic4 , adrenergic5 , serotonergic6, 7, opioidergic8, 9 , and calcium channels10, 11 .

In present study we used Piper Betel for screening of gastrointestinal motility. Piper Betel popularly known as ‘Pan’ in India belongs to family piperaceae. In India Peoples are widely using this after having meals for digestion and warm taste, medicinally it has stimulant, antiseptic, sialogogue activity12. It is reported that calcium is involved in the contraction of smooth muscle. It increases small intestinal motility through L-Type channel10, 11. Thus the present study was designed to investigate the effect of benzene extract of Piper betel on small intestinal motility. The main objective of the present study was to evaluate the involvement of Ca2+ in acceleration of intestinal transit time by using chlorpromazine which blocks calcium channel on smooth muscle cell and relaxes by attenuating intestinal motility.

Material and Method Preparation of Extract: The fresh leaves of Piper betel were collected from local market at village Pusad in Yavatmal district region, Maharashtra, India. The collected leaves of Piper betel were dried under shade and undergone crushing in electric blender to form powdered and subjected to extraction by using Maceration in a air tight closed container by using benzene as a solvent. The extract was concentrated by evaporation at room temperature and used for testing a gastrointestinal motility.

Material: benzene extract of Piper betel leaves, Activated charcoal (S.D. Fine chemical, Mumbai) and Chlorpromazine (La Pharmaceutical Pvt. Ltd., Ahmedabad), Metaclopramide (Wallace Pharmaceutical Ponda,Goa.)

Experimental animals: All the experiments were carried out in adult Swiss albino male mice. The animals were fasted for 15 hrs prior experimentation while had free access to water, and they were housed in a natural (12 hrs each) light–dark cycle. The animals were acclimatized to the laboratory conditions for at least 5 days before exposed for experimentation. The experimental protocol was approved by the Institutional Animal Ethics Committee (IAEC) and the care of laboratory animals was taken according to the guidelines of CPCSEA, Ministry of Forests and Environment, Government of India (registration number 729/02/a/ CPCSEA).

Administration of Extract: Suspension of Benzene extract was prepared in 0.5% carboxymethyl cellulose using tween 20 (0.2% v/v) as a suspending agent. The extract was administered in a dose of 400 and 800mg/kg p.o. respectively. Control groups were given only 0.5% carboxymethyl cellulose with tween 20 (0.2% v/v).
Administration of charcoal: The mice were administered charcoal meal consisting of 4 % of activated charcoal and 2% carboxy methyl cellulose orally (10ml/kg) after 1 hr. of respective treatments.

Administration of Chlorpromazine: The mice were administered with Chlorpromazine (5mg/kg p.o.)30 min prior treated with drugs.

Administration of Metaclopramide: The mice were administered with Metaclopramide (10mg/kg p.o.) as similar with test extract.

EXPERIMENTAL DESIGN Mice were randomly divided into 7 groups of 5 animals each. All the animals were fasted for 15 hrs. Group 1 served as a control and received vehicle only. Group 2, 3 were selected for evaluating acceleratory effects of Piper betel on intestinal transit while group 4, 5, 6 were selected for assessing the calcium channel in acceleration of intestinal transit by using chlorpromazine while group 7 was selected as standard Metaclopramide.

Acceleratory effect of Piper betel on GI transit in normal mice: For evaluation of acceleratory effect on intestinal transit, group 2, 3 received benzene extract of Piper betel (400 and 800mg/kg p.o) respectively.

Statistical Analysis All value are expressed as the mean ± S.D. Statistical significance was assessed by the unpaired Student’s t test for all results.

RESULTS

Acceleratory Effect of Piper betel on Intestinal Transit Benzene extract of Piper betel administration at higher doses (800 mg/kg) produced a significant (P < 0.05 Table 1) acceleration of intestinal transit while at lower dose (400 mg/kg) unable to produce significant effects (Table 1 and Figure 1).

Calcium channel: Influence of Piper betel on delay transit by Chlorpromazine 30 minute prior treatments, group 4, 5, 6, 7 of animals were treated with Chlorpromazine (5 mg/kg p.o.) for induction of delayed intestinal transit. In which group 4 served as a pure Chlorpromazine treated group for evaluating calcium channel in induction of delaying transit time, while remaining groups received benzene extract of piper betel (400 and 800mg/kg p.o) and standard Metaclopramide (10mg/kg p.o) respectively. 1 hr after treatments all the groups of animals were administered 4% activated charcoal meal and 20 min later killed by cervical dislocation for determination of intestinal transit. The small intestine was removed from the pyloric sphincter to the ilioceacal junction and the distance travelled by the charcoal meal was noted and expressed as percentage of intestinal transit using following formula13 .

Cholinergic system: Inhibitory effects of Chlorpromazine Chlorpromazine (5 mg/kg p.o.) produced significant (P < 0.05 Table 1) attenuation of intestinal transit by 28.85% when compared with vehicle treated group. In Chlorpromazinel-pretreated group, administration of benzene extract (400 and 800mg/kg) inhibits the delay of intestinal transit while the significant effect was observed at higher (800mg/kg p.o.) dose only (P < 0.05 Table 1). Chlorpromazine able to produce inhibition of intestinal transit upto 24.47 % in at lowest dose benzene extract of Piper betel.

DISCUSSION The gastrointestinal tract is in a continuous state of contraction, relaxation and secretion. These functions are controlled by neurohumoral systems, which in turn are regulated by various receptor systems, such as cholinergic, adrenergic, serotonergic, opioidergic and calcium channels4-11, 15.The results of the present study indicate that Piper betel accelerate the intestinal transit dose dependently. I found to accelerate the transit by 82.32 and 89.5% at dose of 400 and 800mg/kg of benzene extract of Piper betel respectively. The significant (P < 0.05 Table 1) acceleration was observed at higher dose (800mg/kg) compared to vehicle treated group (Table 1 and Figure 1). Various agents used to evaluate the pathways for acceleration or attenuation of intestinal transits e.g.

Chlorpromazine used for evaluation calcium channel10, 11 , clonidine used for adrenergic pathway14 , naloxone in opioidergic pathway9 , ondasetron in serotonergic system7 , and atropine in cholinergic mechanism4 . In present study we used chlorpromazine was used for delaying in the transit time by interfering calcium channel pathways11 . Calcium is involved in the initiation of contraction of smooth muscle10, 11. The visceral smooth muscle has a poorly developed sarcoplasmic reticulum and the increase in intracellular calcium concentration is primarily due to Ca2+ influx from the extracellular fluid via voltagegated Ca2+ channels15. The L-type calcium channel is present in many cells and it is the main source of Ca2+ for contraction of smooth muscle16. The result of the study found that chlorpromazine significantly inhibit the response of Piper betel by inhibiting the availability of calcium from extracellular sites represent from the result of inhibition of intestinal transit upto 24.47% compared to vehicle control (Table 2) indicating the involvement of Ca2+ channels in normal physiology of small intestinal motility (Table 2). When Chlorpromazine treated group was administered with Piper betel, it reverses the delay of intestinal transit induced by chlorpromazine (Figure 1).

This finding indicates that Piper betel possibly acts through calcium channel. In present study Piper betel increases the intestinal transit possibly by increasing the intracellular calcium concentration through calcium channel. Since, Chlorpromazine could able produce upto 24.47 % inhibitions of intestinal transit in presence lowest dose of Piper betel while in presence of higher dose chlorpromazine was able to inhibit by 15.85% only which was comparable to standard Metaclopramide (Table 1). This indicates Piper betel could partly produce acceleratory effect by increasing the intracellular calcium concentration through calcium channel and also by some other pathways as Chlorpromazine could not completely prevent the acceleratory effect of Piper betel.

References:

1. Horowitz. M., O’Donovan. D., Jones. K.L., Feinle. C., Rayner. C.K., Samsom. M; Diabet. Med, 2002; 19, 177-194

2. Smith. D.S., Ferris, C.D; Drugs, 2003;63, 1339-1358

3. Perusicova. J; Vnitr. Lek, 2004; 50, 338-343

4. Ghosh. M.N; Quantitative study of antagonists on isolated preparations. In: Ghosh MN, ed. Fundamentals of experimental pharmacology. 3rd ed. Kolkata: Hilton and Company., 2005, 134- 147

5. Donoso. M.V., Carvajal. A., Paredes. A., Tomic. A., Koenig. C.S., Huidobro-Toro. J.P; Peptides, 2002; 23, 1663-1671

6. Kiso. T., Ito. H., Miyata. K., Kamato. T., Naitoh. Y., Iwaoka. K., Yamaguchi. T; Eur. J. Pharmacol, 2001; 431, 35-41.

7. Nagakura. Y., Naitoh. Y., Kamato. T., Yamano. M., Miyata. K; Eur. J. Pharmacol. 1996; 311, 67-72

8. Gutstein, H.B., Akil, H; Opioid analgesics. In: Brunton LL, Lazo JS, Parker KL, eds. Goodman and Gilman’s The pharmacological basis of therapeutics. 11th ed. New York: McGraw-Hill Companies, Inc., 2006, 547-590

9. Sternini. C., Patierno, S., Selmer, I.S., Kirchgessner. A; Neurogastroenterol. Motil, 2004; 16 Suppl 2, 3-16

10. Raiha I, Sourander L (1993). GI motility disorders: diagnostic workup and use of prokinetic therapy. Geriatrics. 48(11): 57- 60.

11. Abel MH, Hollingsworth M. The potencies and selectivities of four calcium antagonists as inhibitors of uterine contractions in the rat in vivo. Br J Pharmacol. 1985 May; 85(1):263–269.

12. P. Guha: Betel leaf:The neglected green gold of India. J. Hum Ecol., 19(2) 2006

13. Macht. D. I., and Barbara-Gose. J; J Am. Pharm. Sci. Edu, 1931; 20, 558.

14. DiTullio. N.W., Cieslinski, L., Matthews, W.D., Storer, B; J. Pharmacol. Exp. Ther. 1984; 228, 168-173

15. Horowitz, B., Ward, S.M., Sanders, K.M; Annu. Rev. Physiol. 1999; 61, 19-43

16. Sanders. K.M; Gut, 2000; 47 Suppl 4, iv23- iv25; discussion iv26

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Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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