Piper Betel Popularly known as __ampersandsignlsquo;Pan__ampersandsignrsquo; in India belongs to family Piperaceae. Medicinally it has stimulant, antiseptic, sialogogue activity. It is reported that calcium is involved in the initiation of contraction of smooth muscle. It increase intestinal motility through L-Type. Chlorpromazine blocks the calcium channel on smooth muscle and relaxes by attenuating intestinal motility. The present study was to evaluate the influence of benzene extract of Piper betel (BEPB) on small intestinal motility (SIT). The study was also undertaken to evaluate the mechanism involve in SIT. BEPB (400 and 800 mg/kg p.o) administered to 15 hrs fasted Swiss albino mice. 4% charcoal meal was administered (10 ml/kg p.o) 1hr after the drug administration and after 20 min all animals were dissected for determination of SIT. For exploration of calcium channel in gastrointestinal motility chlorpromazine (5mg/kg p. o.) was administer 30 min prior administration of drug respectively. The results of study indicate that BEPB accelerate the intestinal transit in normal mice. At 800mg/kg dose it was found to accelerate the transit by 89.5% compared to normal mice which was significant at (P __ampersandsignlt; 0.05) compared to vehicle group. Chlorpromazine inhibits GI transit by 28.85% in normal mice. In presence of BEPB it able to reverse the effect ofchlorpromazine, while the significant effect was observed only at 800mg/kg BEPB. In presence of BEPB chlorpromazine could able to produce upto15.85% inhibitions of SIT which was comparable to standard Metaclopramide (10mg/kg p.o) indicates BEPB could partly produce acceleration effect through calcium involvement as well as by some other pathway as chlorpromazine could not completely inhibit the acceleratory effect of Piper betel on small intestinal transit.