International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
logo
slider
slider
slider
slider
Bootstrap Slider

Indexed and Abstracted in: Crossref, CAS Abstracts, Publons, Google Scholar, Open J-Gate, ROAD, Indian Citation Index (ICI), ResearchGATE, Ulrich's Periodicals Directory, WorldCat (World's largest network of library content and services)

Search Articles

Track manuscript

Full Html

IJCRR - Vol 03 Issue 03, March, 2011

Pages: 04-11

Print Article   Download XML  Download PDF

BEHAVIORAL AND BIOCHEMICAL STUDIES OF SEEDS OF CORIANDRUM SATIVUM IN VARIOUS
STRESS MODELS OF DEPRESSION

Author: Kharade SM, Gumate DS, Patil VM, Kokane SP, Naikwade NS

Category: Healthcare

Abstract:Depression is one of the most common and costly brain diseases; there is a need to develop
more effective medications to treat this devastating disorder. Among Indian population there is
an increasing demand for herbal drugs due to their low side effects. Hence the plants are the
good candidates for evaluation of antidepressant activity. The aim of present work was to
investigate the antidepressant activity of seeds of Coriandrum Sativum using various behavioral
models of depression. For this purpose Behavior tests like Forced swimming test and Tail
suspension test were used. And also Biochemical estimation of Monoamine oxidase-B enzyme
activity was carried out. Both extract of Coriandrum Sativum shows significant antidepressant
effect and also inhibit the Monoamine oxidase –B enzyme. Taking together, the finding in the
current study shows that extracts of seeds of Coriandrum Sativum displays a behavioral profile
consistent with an antidepressant like action. Further research should be aimed to isolating the
active principle responsible for antidepressant activity and exploring the mechanism by which
it produce a antidepressant effect.

Keywords: Depression, Forced swimming test, Tail suspension test, Monoamine oxidase-B, antidepressant activity.

Full Text:

INTRODUCTION

Depression is one of the most prevalent psychopathologies in the world. Conventional antidepressant treatment has many limitations such as some are slow to take effect, side effect profile limiting compliance and there are also a large number of treatment resistant patients.1 Such a profile has necessitated new therapeutic strategies in offering faster onset of action and augmenting the therapeutic actions of currently existing antidepressants and thus getting a greater efficacy in a larger proportion of patients. Coriandrum Sativum L. has been recommended for relief of insomnia in Iranian traditional medicine and also brain tonic in Ayurveda2 . On the other hand various plants have been recommended brain tonics wiz. Withania somnifera (Ashwagandha)3 . Asparagus racemosus (Shatavari) 4 . `Bacopa monniera (Brahmi) were evaluated for their antidepressant effect5 . However, no pharmacological activity of Coriandrum Sativum have yet evaluated for its antidepressant effect. As the coriander seeds were evaluated for anxiolytic effect6 . And the present work was undertaken to determine the antidepressant effect of aqueous extracts and fatty oil of coriander seeds. The two models are used for present study i. e. forced swimming test and Tail suspension test. Both models reflect a state of despair which can reduce by several agents which are therapeutically effective in human depression7 . The immobility displayed by rodents when subjected to an unavoidable and inescapable stress has been hypothesized to reflect behavioral despair which in turn may reflect depressive disorders in humans. Clinically effective antidepressants reduce the immobility that mice display after active and unsuccessful attempts to escape when suspended by the tail.7 . It was suggested that mice or rats forced to swim in a restricted space from which they cannot escape are induced to a characteristic behavior of immobility. Measurement of immobility time was carried out by observing the motor activity of mice, which were placed in a pool of water.

MATERIAL AND METHOD Seeds of Coriandrum Sativum were collected from local market in Sangli. The seeds of Coriandrum Sativum identified by the Department of Botany at Deccan Education Society?s Willingdon College, Sangli.\

Preparation of aqueous extract Air dried seeds was homogenized to a fine powder. Hundred grams of powdered coriander was infused in 500 ml cold distilled water for 24 h, brought to the boil, then removed from the heat source and allowed to infuse for 15 min. The extract was filtered, then concentrated over the water bath and brought to dryness under vacuum6 . The yield of the extract was 6.5%.

Preparation of Fixed oil extract The seeds of the Coriandrum Sativum were ground in mixer. The 100gm of powdered material was macerated with 500ml of Diethyl ether for 2 hrs. The solvent was evaporated.8, 9. The yield of the extract was 1.02% w/v. The toxicity study was carried out according the test procedure described in OECD Guideline (425) to estimate acute oral toxicity of drug.10 from the result obtained by toxicity study, it was concluded that the drug extracts are safe and non toxic for use.

Screening methods

Male Swiss mice weighing 25gm were used. The animals were kept under normal light-dark conditions and at a constant temperature. The animals had free access to standard laboratory food and water. The mice were divided three groups, six animals in each group. One group served as control and received distilled water. And other two received 200 mg/kg & 400 mg/kg doses of Aqueous extract of Coriandrum Sativum for Forced swimming test and 300mg/kg & 600mg/kg for Tail suspension test. Aqueous extract of Coriandrum Sativum was suspended in distilled water, immediately prior to use and given as orally dosage. For the Diethyl ether extract, 0.4 ml/kg, 0.6 ml/kg given as orally for Forced swimming test and 0.6ml/kg & 0.8 ml/kg for Tail suspension test.

Forced swimming test After 14 day administration of drug, Measurement of immobility time was carried out by observation the motoric activity of the mice, which were placed in a pool of water. A glass cylinder, 25 cm in diameter, height 23 cm was filled with water to a height of 12 cm. The temperature of water was 23+_ 10 c on the day of testing, after 30 min of dosing animal were subjected to test. Measurement was carried out for six min. The first two minute the animal was allowed to adjust tothe new condition after this two minute, the immobility time that alternated with conditions of enhanced motor activity was measured. Immobility time was measured with a stopwatch for the next four minute11 .

Tail suspension test The tail suspension test was the second method for assessing the antidepressant effect of the extract. Thirty minutes after the single drug or vehicle injection, mice were subjected to the test. A cord of about 50 cm in length was stretched between two mental tripods at a height of ca 70 cm, to which the mice were attached by the tail with sticky tape. After the initial period of vigorous motor activity, the mice become still and the immobility time was measured with a stopwatch, for a total duration of 4 minutes12

Statistics For quantitative data statistical analysis was initially performed by using a one way analysis of variance (ANOVA).

Biochemical estimation Preparation of brain Monoamine oxidase13

Rats (n=12) were decapitated and allowed to bleed. The brains were removed as quickly as possible, placed on a filter paper and their weights determined. All subsequent procedures were performed at 0–4 8C. The brains were rinsed thoroughly in cold saline (0.9% NaCl), then homogenized in 4 volume (w/v) of 0.25 M sucrose, 0.1 M sodium phosphate buffer (pH 7.4) in a Teflon glass homogenizer. The homogenates were centrifuged at 600×g for 10 min. The supernatant fraction was divided into 3-ml portions in small screw-cap vials and kept frozen for later assaying of MAO.

Kinetic assay of MAO-B 13 All assays were carried out in triplicate at 30 � 0.1 0C in 0.1 M sodium phosphate buffer, pH 7.4. Results are mean values � standard deviation of the mean. MAO-B activity was measured using benzylamine as substrate as follows: Mitochondrial protein (100 ml, 600 µg protein) in 0.1 M sodium phosphate buffer, pH 7.4 (total assay volume, 3 ml) was incubated in cuvette (pathlength 10 mm) in Ultramicroscopy and 1000 nm wavelength in UV/visible Spectrophotometer. The reaction was started by addition of benzylamine (25 ml of 1 mM solution in water) and the progress of the reaction (formation of benzaldehyde) was monitored at 250 nm. Initial velocities as A/min were measured from the time scanning of the reactions at 250 nm, ? (M - 1 cm-1 ) 12500. The maximum velocity was expressed as µ mol/mg protein per min13 .

RESULT AND DISCUSSION

Forced swimming test and Tail suspension test are currently most widely used models of animal depression11. And has been validated for use with rat and mice. The indices of depression in these models were “Immobility Time” Shorter immobility time, stronger antidepressant effect. In present study, two doses 200 mg/kg, 400 mg/kg of Aqueous extract and 2 ml/kg, 4 ml/kg of Diethyl ether extract have been administered for 14 successive days in FST model (Table no. 1). While 300 mg/kg and 600 mg/kg of aqueous extract and 6 ml/kg, 8 ml/kg of Diethyl ether extract of seeds of Coriandrum Sativum have been administered for 14 successive days in TST (Table no.2). The efficacies of the extracts were found to be comparable to fluoxetine (SSRI) and Imipramine (Tricyclic antidepressant). While comparing the results obtained by above two models,

Which have been used different stress situations to induce states of terror and despair, it can be observed that the Diethyl ether extract i. e. fatty oil shows more potent effect on reduction of immobility time than aqueous extract(Table no. 3). According to the M. Emamghoreishi et al, the aqueous extract of coriander seed caused a dose dependent general reduction of the spontaneous activity in pentobarbital-induced sleeping time, decreased general locomotor activity and neuromuscular coordination6 . Present study also supports the above findings. But fatty oil of seeds of coriandrum sativum did not show significant change in locomotor activity of mice as compared to control. So it did not produce any motor effect. It is confirmed the assumption that the antidepressant effect of fatty oil of seeds of Coriandrum Sativum is specific. Depression is related to alterations of the monoamine oxidase. MAO-A and MAO-B are biochemical markers of depression. The conversion of Benzyl amine to benzaldehyde has been shown to occur readily in tissue homogenates and to be dependent upon monoamine oxidase activity. The reaction can be followed conveniently in a spectrophotometer and has been developed in to simple and rapid method for the assay of monoamine oxidase14. The results were expressed in % of control. In the present study, the Aqueous extract of seeds of Coriandrum Sativum showed marked decreases MAO-B activity with time(figure no. 1 & 2). Hence aqueous extract of seeds of Coriandrum Sativum showed antidepressant like activity probably by inhibiting MAO enzyme, thus increased monoamine levels of brain.

CONCLUSION

Taking together, the finding in the current study shows that extracts of seeds of Coriandrum Sativum displays a behavioral profile consistent with an antidepressant like action.

1. In the psychopharmacological evaluation, the extracts of seeds of Coriandrum Sativum tested in forced swimming test & Tail suspension test, shows significantly antidepressant like action.

2. On the other hand , it was observed that Diethyl ether extract of seeds of Coriandrum Sativum showed more significant antidepressant effect than that of Aqueous extract when statistically significant difference compared to the control group of animal.

3. MAO-B is one of the biochemical marker of depression, antidepressant drug achieve their therapeutic effect through reversing alteration of this markers. Aqueous extract of seeds of Coriandrum Sativum showed antidepressant activity probably by inhibiting MAO enzyme.

4. By reviewing all the observations of FST & TST , it was indicated that both the extract of Coriandrum Sativum seeds have antidepressant like effect similar to that of Imipramine & Fluoxetine, therefore, it will be used in clinical practice.

References:

1. American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders (DSMIV).4th Edition(2000). American Psychiatric Press Inc, Washington DC, USA..

2. Kirtikar KR, Basu BD. Indian medicinal plants, Vol-II, 5th ed. Delhi: periodical experts book agency(1991). 8 International Journal of Current Research and Review www.ijcrr.com Vol. 03 issue 03 Mar 2011

3. Gupta, Rana. Withania somnifera (Ashwagandha): A Review(2007) Pharmacognosy Reviews.1(1): 129-136.

4. Dr.Moharana Dinabandhu. Shatavari, Jastimadhu and Aswagandha the Ayurvedic Therapy(2008), Orissa Review.1-16.

5. Sheikh, Ahmada A, Siripurapu K, Kuchibhotla V, Singh S, Palit G (2007) Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats, Journal of Ethnopharmacolog.111:671–676.

6. Emamghoreishi M, Khasaki M, Aazam MF (2005) Coriandrum sativum: Evaluation of its anxiolytic effect in the elevated plus-maze. Journal of Ethnopharmacology. 96: 365–370.

7. Vogel HG, Drug Discovery and Evaluation; 2nd ed(2002), New York.542-575.

8. Hosseinzadeh H, Madanifard M (2005) Anticonvulsant Effects of Coriandrum Sativum L. Seed Extracts in Mice; original article.

9. Emamghoreishi M, Heidari-Hamedani H(2006) Sedative-Hypnotic Activity of Extracts and Essential Oil of Coriander Seeds. Iran J Med Sci. 31(1):22-27.

10. OECD guideline for testing of chemicals; Acute Oral Toxicity- Upand-Down Procedure: 425 adapted 17th dec (2001) 1-26.

11. Porsolt RD, Le Pichon M, Jalfre M(1977) Depression: a new animal model sensitive to antidepressant treatments. Nature.266: 730-732.

12. Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology. 85: 367-370.

13. Shaban NZ, Ali AE, Masoud MS(2003) Effect of cadmium and zinc ethanolamine complexes on rat brain monoamine oxidase-B activity in vitro. Journal of Inorganic Biochemistry.95:141–148.

14. Weissbach E, Thomas E, Smith John W, Daly BA (1960)Rapid Spectrophotometric Assay of Monoamine Oxidase Based on the Rate of Disappearance of Kynuramine. J Bioloqical Chemistry. 235(4):1160-1163.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

COPE guidelines for Reviewers

SCOPUS indexing: 2014, 2019 to 2021


Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


RSS feed

Indexed and Abstracted in


Antiplagiarism Policy: IJCRR strongly condemn and discourage practice of plagiarism. All received manuscripts have to pass through "Plagiarism Detection Software" test before Toto Macau forwarding for peer review. We consider "Plagiarism is a crime"

IJCRR Code of Conduct: To achieve a high standard of publication, we adopt Good Publishing Practices (updated in 2022) which are inspired by guidelines provided by Committee on Publication Ethics (COPE), Open Access Scholarly Publishers Association (OASPA) and International Committee of Medical Journal Editors (ICMJE)

Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



ABOUT US

International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

Contact

148, IMSR Building, Ayurvedic Layout,
        Near NIT Complex, Sakkardara,
        Nagpur-24, Maharashtra State, India

editor@ijcrr.com

editor.ijcrr@gmail.com


Copyright © 2023 IJCRR. Specialized online journals by ubijournal .Website by Ubitech solutions