Depression is one of the most common and costly brain diseases; there is a need to develop more effective medications to treat this devastating disorder. Among Indian population there is an increasing demand for herbal drugs due to their low side effects. Hence the plants are the good candidates for evaluation of antidepressant activity. The aim of present work was to investigate the antidepressant activity of seeds of Coriandrum Sativum using various behavioral models of depression. For this purpose Behavior tests like Forced swimming test and Tail suspension test were used. And also Biochemical estimation of Monoamine oxidase-B enzyme activity was carried out. Both extract of Coriandrum Sativum shows significant antidepressant effect and also inhibit the Monoamine oxidase –B enzyme. Taking together, the finding in the current study shows that extracts of seeds of Coriandrum Sativum displays a behavioral profile consistent with an antidepressant like action. Further research should be aimed to isolating the active principle responsible for antidepressant activity and exploring the mechanism by which it produce a antidepressant effect.