International Journal of Current Research and Review
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IJCRR - Vol 04 Issue 05, March, 2012

Pages: 124-129

Date of Publication: 30-Nov--0001


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STUDY OF OESTROUS CYCLE AND HISTOMORPHOMETRY OF OVARY IN DMPA AND A
POLYHERBAL DRUG TREATED ADULT FEMALE ALBINO RATS

Author: Girija Sivakumar, Kamakshi.K.

Category: Healthcare

Abstract:The main aim of the present work is to study the effect of DMPA and a polyherbal on the
estrous cycle and to see the morphometrical changes in the ovary and the serum hormone leves of progesterone and estrogen in adult female albino rats. Animals were divided into four groups groups I as control. Group II,III and IV animals were treated with Injectable contraceptive DMPA at a dose of 0.3mg/kg.body wt./day/animal for one complete estrous cycle (four consecutive days at same interval everyday. Every day the vaginal smear was taken by cotton swab method and stained to see the cyclicity. On the fifth day, Group II animals were
sacrificed. Group III animals were treated with polyherbal drug at a dose of 500mg/kg.body wt./day/animal for next one consecutive cycle and were sacrificed on 9th day. Group IV animals were withdrawn with the injectable contraceptive and from the 5th day to 9th day animals were maintained till day 9 and they were also sacrified on 9th day. Animals of all the
groups were sacrificed by euthenesia method and ovaries were collected after proper perfusion and fixed in 10% formalin for histological and histomorphometric study. Control group of animals showed regular estrous cycle with four stages \? proestrous,estrous,metestrous and
diestrous. DMPA treated group of animals showed prolonged diestrous stage. Polyherbal drug
treated group showed a recovery to the normal cyclicity whereas the Group IV animals though
there was a recovery it was very slow and in some animals the stage remained in diestrous stage itself. Ovary showed atretic follicles and more of corpus luteum when compared to control and group III animals showed more of mature and secondary follicles when compared to group IV animals.

Keywords: oestrous cycle – DMPA – polyherbal drug – histomorphometry

Full Text:

INTRODUCTION
The menstrual cycle in women has been disturbed by various stress factors like chemical, physical, hormonal imbalance, emotional, psychological etc., All these disturbances lead to many changes in their reproductive cycle which includes irregular menstrual cycle, ovarian disturbances, etc., Various treatments have been taken by those women to regularize and normalize their disturbance in the reproductive cycle and reproductive organs and many of them end in vain. The main aim of the present work is to study the stress related changes occurring in reproductive cycle and the ovarian changes observed and a trial has been taken to observe the recovery of the animals by a poly-herbal drug formulation. The work has been carried out as trial in animal study using adult female albino rats as the estrous cycle can be compared with the menstrual cycle in human. ( Short,1972)

MATERIALS AND METHODS
Adult female albino rats weighing about 110-120gms were selected for the present study. Animals were procured after the approval of CPCSEA (No.01/002/2000), (No.01/010/2003). Demedroxyprogesteroneacetate (DMPA) which is commercially available in the name of Depo-provera was used as a chemical stress to induce disturbance in the estrous cycle in animals. A polyherbal drug formulation containing Crocus sativus,Cinamonumcamphora,Abromaaugu sta, Vitisquandragularis,Saracaindica was used to observe the recovery of the animal in its reproductive changes. These herbs were believed to have uterotonic effects (Thirugnanam,1994; Shanmugam,1989;Warrier,1994,Sangeetha, Mathur, Prakash,1989;Murugesa mudaliar,1998; KirtikarandBabu,1999) Animals were divided into four groupsof six animals each. Animals were caged in such a way three female and one male in the same cage with a meshed partition. All the animals were monitored for their normal estrous cycle by doing vaginal smear for two consecutive cycles and confirmed with their normal cyclicity. Then the animals were grouped and experimented. Group – I Control; Group – II DMPA treated; Group III – Polyherbal drug treated; Group IV – Withdrawal of DMPA. Group I animals were maintained with the normal feed and water till the end of the experiment. Group II animals were treated with DMPA at a dose of 0.03mg/kg.body wt./day/animal. This is to induce a disturbance in the estrous cycle of the group II animals (Amatayaku,1979). Group III animals were treated with polyherbal drug formulation from the day 5 after they were treated with DMPA same as like group II animals. It was given at a dose of 500mg/kg.body wt./animal. Polyherbal drug was given for the next following estrous cycle. Group IV animals were treated with DMPA same like group II,drug was withdrawn from 5th day and the animals were monitored from day 5 till the end of the experimental period. Tissues were subjected to histological study using routine Haematoxylin and Eosin stain and Histomorphometric study using Ocular and Stage Micrometer. Volume of the follicles, corpus luteum, were studied using reticule (BloomandFawcett,1968). Progesterone and Estradiol Hormonal assay were done using RIA kit (Coat-a-count method) of M/s Diagnostic Products Corporation (DPC), USA (Berquist et.al., 1983).

Methods
Control group of animals were subjected to vaginal smear study at a regular interval of 6 hours every day till the end of the experiment. Group II animals were treated with DMPA intramuscularlyeveryday at a dose of 0.3mg/kg.body wt./day/animal for one complete estrous cycle at regular interval Everett,1996). The first injection was given at 6pm once identifiedwith itsproestrous stage. On the fifth day the same time all the animals were sacrificed. Group III animals were treated with DMPA in the same way simultaneously along with Group II animals and from the fifth day for the next consecutive cycle they were treated with the polyherbal drug formulation orally at a dose of 500mg/kg.body wt./day/animal for four consecutive days. On the 9th day all the animals were sacrificed. Group IV animals were also treated with DMPA same like group II and after the 4th day, the animals were left free to monitor their recovery without any drug administration. On the 9th day group I, III and IV were sacrificed and tissues were collected for the study of all parameters. Animals were sacrificed by euthenesia. First animals were anaesthetized and were then sacrificed using overdose of chloroform. Then the animals were perfused properly using normal and formal saline. Ovaries were removed and fixed in 10% formalin for morphology, histology and histomorphometric studies. Ovaries were stained by routine Haematoxylinand Eosin method (Bancroft,1982). Histomorphometric studies were done on follicular and the luteal size (HirshfieldandMidgley,1978a).

Observations
Observations were made in all the four groups of animals on the following aspects Vaginal cytology, Morphology,Histology,MorphometryandHist omorphometry and progesterone and estradiol assay.

Vaginal cytology: In the control group, the vaginal cytology exihibited all the regular four stages of estrous cycleproestrous,estrous,metestrous and diestrous at regular intervals as per the literature study (Long and Evans,1922). All the stages existed as per the indicated duration. Vaginal smear showed different types of cells at different stages (Mandl,1951)Proestrous stage contains nucleated cells of different sizes and shape. Estrous stage showed cornification and squamatization of cells as a result of which the nucleus were seemed hidden and were not identified. Also the cells existed either single or in cluster of two or three cells. The vaginal liquid appeared clear and watery. In metestrous stage the cells got infiltered with leucocytes due to which the periphery of the cornified cells were bounded by leucocytes. The diestrous stage had only leucocytes and none other cells were identified. This stage is refered to as resting stage where no reproductive activity will take place. The vaginal fluid appears highly viscous and milkfish white inappearance. The duration of each stage had been shown in the tabulated column. In the DMPA treated group, the vaginal smear showed only a prolonged stage of diestrous stage as a result which it contains only leucocytes and none other cells. That indicates the animal remains in the resting stage (BhowmikandMukherjea,1988). In Polyherbal drug treated group, vaginal smear showed the recovery of different stages of estrous cycle that were identified with the control group. Cells of different types like nucleated in proestrousstage,squamatized cells in estrous stage were identified. In the group IV, after the withdrawal of DMPA the vaginal smear showed recovery of the normal cycle but the duration seemed to be longer than the polyherbal drug treated group. All the vaginal observations were shown in the tabulated column and compared by the bar diagram.

Morphology : Group I animals showed small oval ovary where as in group II the ovary became enlarged and irregular shaped structure. Group III and Group IV animals showed a varied size and shape when compare to group II animals.

Histology : In group I animals, the ovary showed follicles of different stages – primary, secondary, mature and graffian follicles (Mandl,andZukerman, 1952). Corpus luteum found to be present more in number in diestrous stage as it a resting stage. In group II animals, almost all the ovary showed more number of corpus luteum than the follicles and the size of the corpus luteum also found to be bigger than the group I animals (Oateberg,1979). In group III and IV animals, there was a considered increase in the number of follicles when compared to group II animals. There was difference in the follicular existence in group III and group IV animals. Histological studies were shown in the photographs.

Histomorphometry:Studies like size of the follicles of different stages, size of the corpus luteum, and volume of the ovarian tissue were tabulated and represented by bar diagrams. Follicular and Luteal diameters were measured and compared by bar chart.

Hormonal study : In the control group of animals, the progesterone estrogen levels fluctuate during different stages of estrous cycle (Nequin,AlvarezandSchwartz,1979). In DMPA treated group, the animals remained in prolonged diestrous stage and the hormonal assay were done at the diestrous stage in all the group of animals (PageandButcher,1982). The hormonal changes were tabulated and represented by graphical diagrams. Group III and IV animals show a recovery to their normal cyclicity and that of the group III is faster and regular in recovery than the group IV animals which are slow in recovery and also some animals remained in diestrous stage itself.

CONCLUSION
Group I animals showed normal estrous cycle with the four stages as per the literature study. Ovaries showed different stages of the growing follicles and the size of the corpus luteum remained as same as per the literature study. Group II animals showed a prolonged diestrous stage where the vaginal cytology smear showed the existence of leucocytes only. Ovary showed extensive number of corpus luteum. Ovarian follicles remained atretic condition and few primary follicles were identified. Group III animals which were treated with polyherbal drug formulation showed a gradual and fast recovery to normalcy with the evidence of the presence of cornified epithelial cells, nucleated cells and leucocytes at specified stages. Ovaries showed the gradual existence of follicles of different stages and the corpus luteum. In group IV, vaginal smear showed the recovery from the prolonged existence of diestrous stage, but in a slow manner and in some animals the recovery were not observed in the experimental period. Ovaries started showing few secondary follicles and one or two mature follicles. From the above study, it was clearly noticed that there was drastic effect of the usage of contraceptive (DMPA) on the estrous cycle and eventually disturbed the normal histology and histomorphometry of ovary. The treatment of the polyherbal drug on the contraceptive treated animals seemed to be very effective in regularizing the estrous cycle and subsequently produced changes in bringing back the normal histology of the ovary and it was proved by the histomorphometric studies. The withdrawal of DMPA also showed some effect in bringing back the normal cycle of the animal but not as effective as group III and also found to be less when compared to normal group. The serum progesterone and estrogen levels also found to be regularized in group III which were remaining in a single concentration in group II. They found to be more or less same in both Group III and IV.

ACKNOWLEDGEMENT
Authors acknowledge the immense help received from the scholars whose articles are cited and included in references of this manuscript. The authors are also grateful to authors/editors/publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

References:

1. Allen,E.(1922) The oestrous cycle in the mouse. American Journal of Anatomy 30:297-371

2. Ambasta,S.P.(1986) Abromaaugusta. Useful plants of India.Chap.2

3. Bancroft,D.J.(1982) Theory and Practice of histological techniques. Printed at Longmann group Ltd.,

4. Bloom,W. and Fawcett,D.W.(1968) A textbook of histology 9th edition P.No.858. Printed at Philadelphia: Saunders.

5. Boling,J.L. Blandau,R.J. Soderwall,A.L. and Young W.C.(1941) Growth of the graffianfollicels and the time of ovulation in albino rat. Anatomical Record.79:313-332.

6. Bhowmik,T. and Mukherjea,M.(1988) Histological changes in the ovary and uterus of rat after injectable contraceptive therapy. Contraception. 37(5):530-534.

7. Evrard,J.R. Buxton,B.H. and Rickson,D. (1976) Amenorrhea following oral contraception. American Journal of Obstreticsand Gynaecology.124:88

8. Everett,S.(1966) Injectable contraception,119-126. Handbook of contraception and Family planning. WBC Book Manufacturers,London.

9. Freeman,M.E.(1988) The ovarian cycle of the rat. Chapter 45:1893-1914 Printed at Raven Press Ltd., NewYork.

10. Hirshfield, A.N. and Midgley,A.R.(1978a) Morphometric analysis of follicular development in the rat. Biology of Reproduction.19:597-605

11. Kirtikar,K.R. and Babu,B.D.(1999) Abromaaugusta Indian Medicinal Plants,I.380-881.

12. Lee,R.A.(1969) Contraceptive and Endometrial effects of Medroxyprogesteroneacetate. American Journal of Obstreticsand Gynaecology.104:130-133.

13. Long, J.A. and Evan, H.M. (1922) The estrous cycle in the rat and its associated phenomenon. Memoirs ofUniversity of California. 6:1-148.

14. Mandl,A.M.(1951) The phases of the estrous cycle in the adult white rat. Journal of Experimental Biology.28:576-585.

15. Mandl,A.M. and Zuckermann,S.(1952) Cyclic Changes in the number of medium and large follicles in the adult rat ovary. Journal of Endocrinology.8:341-346.

16. Oateberg, E.G.(1979) Follicular growth and atresia in the mouse. Invitro 15:41-49

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Awards, Research and Publication incentive Schemes by IJCRR

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One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
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A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by situs slot and Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh et al. situs slot "Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma situs slot entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by situs slot et al entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09
Late to bed everyday? You may die early, get depression situs slot
Egg a day tied to lower risk of heart disease situs slot
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List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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