The main aim of the present work is to study the effect of DMPA and a polyherbal on the estrous cycle and to see the morphometrical changes in the ovary and the serum hormone leves of progesterone and estrogen in adult female albino rats. Animals were divided into four groups groups I as control. Group II,III and IV animals were treated with Injectable contraceptive DMPA at a dose of 0.3mg/kg.body wt./day/animal for one complete estrous cycle (four consecutive days at same interval everyday. Every day the vaginal smear was taken by cotton swab method and stained to see the cyclicity. On the fifth day, Group II animals were sacrificed. Group III animals were treated with polyherbal drug at a dose of 500mg/kg.body wt./day/animal for next one consecutive cycle and were sacrificed on 9th day. Group IV animals were withdrawn with the injectable contraceptive and from the 5th day to 9th day animals were maintained till day 9 and they were also sacrified on 9th day. Animals of all the groups were sacrificed by euthenesia method and ovaries were collected after proper perfusion and fixed in 10% formalin for histological and histomorphometric study. Control group of animals showed regular estrous cycle with four stages __ampersandsignndash; proestrous,estrous,metestrous and diestrous. DMPA treated group of animals showed prolonged diestrous stage. Polyherbal drug treated group showed a recovery to the normal cyclicity whereas the Group IV animals though there was a recovery it was very slow and in some animals the stage remained in diestrous stage itself. Ovary showed atretic follicles and more of corpus luteum when compared to control and group III animals showed more of mature and secondary follicles when compared to group IV animals.