International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 09 Issue 02, January, 2017

Pages: 01-04

Date of Publication: 20-Jan-2017


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Retrospective Study of CNS Tumors in Tertiary Care Hospital

Author: Rajul Iqbal Desai, Nidhi Shailesh Soni, Iqbal Mohammad Desai, Kunjlata Rajput

Category: Healthcare

Abstract:Background: Central Nervous System(CNS) tumors are group of neoplasms having different prevalence in different sex and age groups and various parts of CNS. The aim of our study to show the prevalence of various brain tumors and their age and sex distribution.
Methodology: The present 1.5 years study from a single tertiary care center, Gujarat research and medical institute, the patient diagnosed with CNS tumors and registered between 2014 and 2015 in the pathology department were consecutively screened. The inclusion criteria were cases of CNS tumors of all age groups. The tumors of peripheral nervous system. With these criteria, a total of 107 cases of CNS tumors were studied, and their histological typing and grading was done.
Result: All the CNS tumors were divided into seven categories: Tumors of neuroepithelial tissue; tumors of the cranial and paraspinal nerves; tumors of the meninges; lymphomas and hematopoietic neoplasms; germ cell tumors; tumors of the sellar region; and metastatic tumors. most common lesions were Astrocytic Tumours followed by Meningeal Tumors. Male to Female ratio is 1.0 : 0.98.
Conclusion: Nowadays there is an increase in incidence of CNS tumors in developing countries because of advanced health care and diagnostic facilities. Astrocytic tumors are the most common followed by meningeal tumors. The study shows prevalent pattern and comparison with similar studies. This may help in locating prevailing etiological index of that region.

Keywords: Astrocytoma, Central nervous system, Meningioma

Full Text:

INTRODUCTION

Brain tumors though not very common, result in significant morbidity because of their poor survival rate. A number of studies from Western countries have reported on the pattern, incidence and mortality of brain and central nervous system (CNS) tumors. Tumors of the central nervous system are a group of neoplasms having different prevalence in different sex and age groups and various parts of CNS. The tumors of central nervous system are reported to be less than 2% of all malignancy1. In developing countries like India, there is lack of resources which result in missing the diagnosis of new cases hence the exact tumor burden is underestimated. Hospital-based prevalence data, therefore, forms the basis for estimating the disease load. Nowadays health care and diagnostic facilities have advanced which leads to  increase in incidence of CNS tumors in developing countries.3                

All the CNS tumors were divided into seven categories: Tumors of neuroepithelial tissue; tumors of the  cranial and paraspinal nerves; tumors of the meninges; lymphomas and hematopoietic neoplasms; germ cell tumors; tumors of the sellar region; and metastatic tumors. The WHO classification offers a crude histological grading system, in which each CNS tumor is classified as Grades I-IV according to its degree of malignancy. This system can provide an estimate for the prognosis of a patient. In this study, age, sex and the histological tumor type and grade were systematically recorded.

MATERIALS AND METHODS

The present 1.5 years study from a single tertiary care center, Gujarat research and medical institute, the patient diagnosed with CNS tumors and registered between 2014 and 2015 in the pathology department were consecutively screened. The H and E stained histopathological slides of biopsy received were evaluated. The cases were diagnosed and characterized where necessary using Immuno-histochemistry and categorized according to the WHO 2007 classification. The inclusion criteria were cases of CNS tumors of all age groups. The tumors of peripheral nervous system. With these criteria, a total of 107 cases of CNS tumors were studied, and their histological typing and grading was done.

RESULTS

Total 107 cases were found at Gujarat Research Medical Institute, GRMI, Rajasthan Hospital for the period of 1.5 years. In our study most common lesions were Astrocytic Tumours  followed by Meningeal Tumors .  Out of total 107 cases of CNS tumours, 25 cases were of Astrocytic Tumours and 21 cases  were of Meningeal tumours. There was almost equal sex ratio as there were 54 males & 53 females out of 107 cases of CNS tumours. Male to Female ratio is 1.0 : 0.98

In our study, age distribution revealed that tumors were more common in age group 41 to 50 years (32 cases)  followed by 31 to 40 years (22 cases).

In our study it is observed that Astrocytic Tumours have almost equal distribution in both Males & Females, However in Meningeal tumours are more common in females. And in the others category the most common tumor was Pituitary adenoma (12 cases).

DISCUSSION

In our study, we noted that Astrocytic tumour was the commonest tumor (23.31%) which was contrary to  Surawicz et al (1999)[5] in USA & Lee et al (2010)[6] in Korea  noticed that most common tumor was meningioma (31.2%).

Aryal G. et al (2011)[9] in Nepal noticed that astrocytomas were most common tumors of CNS followed by meningiomas. According to Materljan E et al (2004)[8], neuroepithelial tumors were common CNS neoplasm. Sex distribution showed that meningioma affects females more than males, as it was noted by Surawicz et al.[5]

In our study, astrocytoma was seen in males & females equally. According to Surawicz et al (1999) gliomas affect about 40% more males than females.[5] Our study showed that male to female ratio was 1.0 : 0.98, but  according to Balkishan B Yeole et al (2008) , brain – nervous system cancer were more common in male than female.[1] But according to Lee et al (2010) 6 CNS tumors occurred in females more often than in males (female to male, 1.43: 1).

According to WHO classification, majority of lesions belonged to Grade I in comparison to grade III or IV. But in cases of astrocytoma, grade III lesion was more common in comparison to Grade I lesion.

CONCLUSION

Nowadays there is an increase in incidence of CNS tumors in developing countries because of advanced health care and diagnostic facilities. Astrocytic tumors are the most common followed by meningeal tumors. The study shows prevalent pattern and comparison with similar studies. This may help in locating prevailing etiological index of that region.

References:

1. Tamkeen Masoodi, Ram Kumar Gupta et al, JK-Practitioner 2012;17(4),42-46.

2. Balkrishan B Yeole et al, Trends in Brain Cancer Incidence in India, Asian Pacific Journal of cancers prevention, Vol 9,2008

3. Sarita N, Kanwardeep K et al, Histopathological spectrum of CNS tumors, IJSS 2015;3(6),130-134.

4. Jain A, Sharma MC, Suri V, Kale SS, Mahapatra AK, Tatke M, et al. Spectrum of pediatric brain tumors in India: A multi-institutional study. Neurol India 2011;59:208-11.

5. Surawicz TS, Davis F, et al. Brain tumor survival: results from the National Cancer Data Base. (Accepted for publication in Journal of Neuro-Oncology).

6. Hoffman S, Propp JM, McCarthy BJ. Temporal trends in incidence of primary brain tumors in the United States, 1985-1999. Neuro Oncol 2006;8:27-37.

7. Alexandru D, Bota DA, Linskey ME. Epidemiology of central nervous system metastases. Prog Neurol Surg 2012;25:13-29.

8. Materljan E, Materljan B, Sepcić J, Tuskan-Mohar L, Zamolo G, Erman-Baldini I. Epidemiology of central nervous system tumors in Labin area, Croatia, 1974-2001. Croat Med J 2004;45:206-12.

9. Aryal G. Histopathological pattern of central nervous system tumor: A three years reterospective study. Journal of Pathology of Nepal, 2011;1:22-5.

10. Rigau V, Zouaoui S, Mathieu-Daudé H, Darlix A, Maran A, Tré- tarre B, et al. French brain tumor database: 5-year histological results on 25 756 cases. Brain Pathology,2011;21:633-44.

Research Incentive Schemes

Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

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‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma COLAKOGLU entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by Arpita M. et al entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09
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List of Awardees

Awardees of COVID-19 Research

Woman Researcher Award

A Study by Neha Garg et al. entitled "Optimization of the Response to nCOVID-19 Pandemic in Pregnant Women – An Urgent Appeal in Indian Scenario" published in Vol 12 issue 09

A Study by Sana Parveen and Shraddha Jain entitled "Pathophysiologic Enigma of COVID-19 Pandemic with Clinical Correlates" published in Vol 12 issue 13

A Study by Rashmi Jain et al. entitled "Current Consensus Review Article on Drugs and Biologics against nCOVID-19 – A Systematic Review" published in Vol 12 issue 09

Emerging Researcher Award

A Study by Madhan Jeyaraman et al. entitled "Vitamin-D: An Immune Shield Against nCOVID-19" published in Vol 12 issue 09


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