International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - 7(15), August, 2015

Pages: 26-31

Date of Publication: 11-Aug-2015


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INVASIVE LOBULAR BREAST CARCINOMA (ILC) IN AN ELDERLY MALE ON PROLONGED RANITIDINE THERAPY

Author: Srikantaiah Hiremath, Nikhil Nanjappa B. A.

Category: Healthcare

Abstract:Breast carcinoma in men is an exceedingly rare entity, contributing to 1% of all breast cancers [1], of which invasive lobular carcinoma (ILC) accounts for 1.5% [2]. The average age at diagnosis is usually five years older compared to women [1, 3]. Although the exact aetiology remains unknown, hyperestrogenic states are attributed as the most likely cause [4]. Men with family history of female breast cancer are at 2.5 times more increased risk when compared to those with no family history [5]. Lobular histologic subtype of breast carcinoma in males is rare due to the lack of acini and lobules [6]. Some medications, such as cimetidine
[7, 8] are thought to multiply the risk of male breast cancer because they induce a hyperestrogenic state. The authors report a rare case of ILC in a 75 year old man, with no known risk factors for breast cancer. However, he had a history of prolonged self-prescribed ranitidine use for dyspeptic symptoms. Although there isn't enough evidence to suggest that ranitidine, like its predecessor cimetidine, may cause male breast cancer. The authors would like to draw attention to this possibility.

Keywords: Male breast carcinoma, Male breast cancer, Invasive lobular carcinoma males, Ranitidine induced male breast cancer

Full Text:

INTRODUCTION

Breast carcinoma in men is an exceedingly rare entity. As the incidence is very low, the exact aetiology remains unknown; however, it is largely attributed to oestrogen excess states. Men who have family history of female breast cancer are at 2.5 times increased risk when compared to those with no family history [5]. The average age at diagnosis is five years older compared to women [1, 9]. Most of the breast cancers in men are of ductal (in situ and invasive) type. Invasive lobular cancer is an extremely rare histopathological type of male breast cancer because lobular and acinar components are rarely found in the normal male breast [10]. Breast cancer in men carries a worse prognosis when compared to women, although the principles of management remain the same. We present an extremely rare case of invasive lobular carcinoma (ILC) in an elderly gentleman with no other risk factors but for prolonged ranitidine therapy. Although there is not enough evidence to suggest that ranitidine, like its predecessor cimetidine, may cause male breast cancer, the authors would like to draw attention to this possibility.

CASE REPORT

A 75 year old male fruit vendor presented with complaints of a lump in the right breast since 7 months. The lump developed insidiously and was associated with pain that led him to seek medical intervention. He did not have any associated medical co-morbidities and was not on any chronic medications. He did not have any history of gynaecomastia and was not on any form of hormone replacement therapy. His scrotum was normal on examination. He did not have any family history of breast or ovarian cancers. On retrospective questioning he admitted that would often consume ranitidine tablets for symptoms of gastritis which was easily available over the counter. On examination he had a 3*3 cm hard lump in the central quadrant of the right breast; the mobility ofwhich was restricted indicating fixity to the pectoralis muscle (Fig. 1). There was another hard 1*1 cm solitary lump lateral but separate from the aforementioned lump. One hard solitary central group lymph node was palpable on examination of the right axilla. Clincal AJCC stage of the tumour was T4cN1M0. Ultra sonogram of the breast and axilla complimented the clinical findings. A whole body PET-CT did not reveal any evidence of distant metastasis. Fine needle cytology evaluation confirmed the diagnosis of carcinoma breast in the primary lump, the satellite nodule as well as in the axillary lymph node. The patient underwent a modified radical mastectomy of the right breast (Fig. 2 and 3). Histopathological examination of the specimen showed invasive malignant tumour comprising of tumour cells arranged in nests and trabeculae. The tumour cells possessed round nuclei with minimal atypia, vesicular chromatin and prominent nucleoli. Stromal desmoplasia was seen along with mild lymphocytic infiltration. Multiple microcalcifications were present along with some perineural involvement. The overlying skin and underlying skeletal muscles were involved. Metastasis was present in 3 of the 9 lymph nodes studied along with extranodal spread. These findings were consistent with invasive lobular carcinoma (Fig. 4 and 5). Pathological AJCC stage was IIIB (pT4N1M0). The tumour was both estrogen and progesterone receptor positive on immunohistochemistry. The patient was advised to receive adjuvant chemotherapy but was not compliant. However, he has been on Tamoxifen (100 mg) for the last four years and has had no recurrence.

DISCUSSION

Breast carcinoma in men is an exceedingly rare entity. The prevalence of which is one per 100,000 persons and accounts for less than 1% of all breast cancers. It is responsible for less than 1% of all male malignancies [1]. The average age at diagnosis is usually between 63 and 71 years which is five years older compared to women with a range of 58 to 93 years [1, 2, 3]. This gentleman was 75 years old at the time of diagnosis which is a little more than the average, but consistent with the fact that male breast cancers occur in the 7th and 8th decades of life. Since male breast carcinomas have a low rate of incidence the exact aetiology remains largely unknown. However, some risk factors have been elucidated. Androgen aromatisation, obesity and alcoholic liver disease all of which are associated with increased levels of sex steroid binding globulin. These in turn incite a state of oestrogen excess and remain the most probable aetiologies [4]. Undescended testes, orchitis, orchiectomy, and sterility are other risk factors, albeit a causal association is yet to be determined. Some medications, such as cimetidine, are thought to multiply the risk of male breast cancer due to hyperestrogenism [5, 6]. A few controlled studies in animals and man have shown no stimulation of any pituitary hormone by ranitidine hydrochloride and no antiandrogenic activity. Studies have even claimed that cimetidine-induced gynaecomastia and impotence reduced when cimetidine was substituted with ranitidine [7]. However our patient was on long term over the counter ranitidine treatment. Whether ranitidine also has the same properties of its predecessor cimetidine remains unknown. Anecdotal evidence such as this may not be sufficient to justify our claim, but there certainly is a possibility that should be looked at. Men who have a family history of female breast cancer are at 2.5 times increases risk when compared to those with no family history [8]. Some studies attribute mutations in the genes BRCA1 and BRCA2 to male breast cancer but with a lower absolute risk and frequency compared to women [9]. Data from SEER (Surveillance, Epidemiology, and End Results cancer registry) of 2000 patients showed that 93.7% of breast cancers are ductal man or unclassified, 2.6% were papillary, 1.8% is mucinous and only 1.5% are lobular [2]. The ductal carcinoma in situ (DCIS) accounts for 10% of male breast cancers [2]. The in situ lobular carcinoma (LCIS) is rare due to the absence of terminal lobules, although it is found in association with ILC [10]. Goss et al. reported 1.9% of all male breast cancers as ILC [11]. Nahleh et al. reported the highest percentage of ILC when they analysed the Veterans Affairs Central Cancer registry with 612 male breast cancer patients [12]. ILC is completely different entity from the much more common invasive ductal carcinoma (IDC). Although ILC accounts for 12% of all female breast cancers, they are exceedingly rare in the male breast [13]. Lobular histologic subtype of breast carcinoma is due to the lack of acini and lobules in the normal male breast [14]. Endogenous or exogenous estrogenic stimulation may incite the development of acini and lobules in the male breast; this is referred as ‘lobulization’of the male breast. This could theoretically increase the risk of development of ILC in males [14]. ILC displays a wide variety of histologic subtypes from classical through solid to pleomorphic forms. The classical variant is found to have better prognosis. Male breast cancers are strongly hormone dependent tumours. Almost 90 and 81% are estrogen and progesterone receptor positive respectively [2, 15]. But overexpression and/or amplification of the Her2 gene is less than IDC [16]. Our patient was both oestrogen and progesterone receptor positive and has been on Tamoxifen daily for the last 4 years.

ILC characteristically lacks E-cadherin expression on immunohistochemical (IHC) staining and this property is now used as a diagnostic aid [10]. We were unable to carry out IHC staining due to cost constraints and hence reserve any judgements. Male breast cancer carries a worse prognosis than female [2]. This could be attributed to the lack the lobular component allowing the tumour to invade local structures like the chest wall more rapidly and also distant spread occurs sooner due to the same reason. Tumour size and the lymph node involvement are important prognostic factors just like in females [2]. Men with T2 tumours have a 40% increased mortality risk compared to those with T1 tumours [5]. Our patient presented with a T4a tumour for which he underwent a modified radical mastectomy. Despite having chosen not to receive adjuvant chemotherapy he has no evidence of recurrence and has survived for 4 years after the surgery. We do not wish to enter the debate on the need for adjuvant chemotherapy as the evidence is only anecdotal.

CONCLUSIONS

• The first case of ILC without known estrogen exposure was reported in 1989 [13], and about 30 cases have been reported since. Hence we felt the need to report this case.

• This gentleman had no history of gynaecomastia, no evidence of testicular abnormalities, no liver cirrhosis, no family history of breast or ovarian cancer, and was not on any hormone replacement therapy, but still developed invasive lobular breast carcinoma.

• The only possible contributory factor was chronic consumption of ranitidine.

• Ranitidine is easily available over the counter at a fraction of the cost compared to proton pump inhibitors. Dyspeptic symptoms are easily attributed to gastritis, especially in the elderly.

• Although there is isn’t sufficient evidence to suggest that ranitidine is a potential risk factor, there lies a pressing need to study this association further.

References:

1. Tunon de Lara C, G Goudy, MacGrogan G, M Durand, JM Dilhuydy, Avril A, E Stoeckle, I Bussieres, Debled M, De Mascarel I, Mauriac L. Breast cancer in humans: about 52 If supported in BergoniéInstitute of Bordeaux between 1980 and 2004. Obstetrics and Gynecology Fertility 2008 Apr; 36 (4): 386-394.

2. Giordano SH, DS Cohen, Buzdar AU, Perkins G, Hortobagyi GN. Breast carcinoma in men: a population-based study. Cancer. 2004 Jul 1; 101 (1): 51-7.

3. Goss PE, Reid C, Pintilie M, Lim R, N Miller. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital Pendant 40 years: 1955-1996 Cancer. 1999 Feb 1; 85 (3): 629-39.

4. JR Weiss, Moysich KB, Swede H. Epidemiology of male breast cancer. Cancer Epidemiol . Biomarkers Prev 2005; 14 (1): 20- 26.

5. Sorensen HT, Friis S, Olsen JH, Thulstrup AM, Mellemkjaer L, Linet M, Trichopoulos D, Vilstrup H, Olsen J. Risk of breast cancer in men with liver cirrhosis. Am J Gastroenterol. 1998;93:231–233.

6. San Miguel P, Sancho M, Enriquez JL, Fernandez J, GonzalezPalacios F. Lobular carcinoma of the male breast associated with the use of cimetidine. Virchows Arch. 1997;430: 261–263.

7. The Internet Drug Index (RxList). California: The Internet Drug Index [Cited 2015 March 1]. Available from: http://www.rxlist. com/zantac-drug/side-effects-interactions.htm

8. Laabadi K, Jayi S, Alaoui FF, et al. Breast Cancer man: about 6 cases. The Pan African Medical Journal 2013; 16: 70.

9. Sverdlov RS Barshack I, Bar Sade RB, RG Baruch, Hirsh-G Yehezkel, Dagan E, Feinmesser M Freeze A, Friedman E. Genetic analysis of male breast cancer in Israel. Genet Test. 2000; 4 (3): 313-7.

10. Espiémillion Gorins A. Breast normal to pathological: state of the art. Oxford University Press; 2001.

11. Goss PE, Reid C, Pintilie M, Lim R, Miller N. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996. Cancer. 1999;85:629–639.

12. Nahleh ZA, Srikantiah R, Safa M, Jazieh AR, Muhleman A, Komrokji R. Male breast cancer in the veterans affairs population: a comparative analysis. Cancer. 2007;109: 1471–1477.

13. Giordano SH. A review of the diagnosis and management of male breast cancer. Oncologist. 2005;10(7):471–479.

14. Zahir MN, Minhas K, Shabbir-Moosajee M. Pleomorphic lobular carcinoma of the male breast with axillary lymph node involvement: a case report and review of literature. BMC Clinical Pathology 2014;14:16.

15. Maly B, Maly A, Pappo I, Meir K, Pappo O. Pleomorphic variant of invasive lobular carcinoma of the male breast. Virchows Arch. 2005;446(3):344–345.

16. Varga Z1, Mallon E. Histology and immunophenotype of invasive lobular breast cancer. Daily practice and pitfalls. Breast Dis. 2008-2009; 30:15-9.

Announcements

Dr. Pramod Kumar Manjhi joined Editor-in-Chief since July 2021 onwards

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Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor@ijcrr.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor@ijcrr.com for more details.


Best Article Award

A study by Dorothy Ebere Adimora et al. entitled \"Remediation for Effects of Domestic Violence on Psychological well-being, Depression and Suicide among Women During COVID-19 Pandemic: A Cross-cultural Study of Nigeria and Spain\" is awarded Best Article of Vol 14 issue 23
A study by Muhas C. et al. entitled \"Study on Knowledge & Awareness About Pharmacovigilance Among Pharmacists in South India\" is awarded Best article for Vol 14 issue 22
A study by Saurabh Suvidha entitled \"A Case of Mucoid Degeneration of Uterine Fibroid with Hydrosalphinx and Ovarian Cyst\" is awarded Best article of Vol 14 issue 21
A study by Alice Alice entitled \"Strengthening of Human Milk Banking across South Asian Countries: A Next Step Forward\" is awarded Best article of Vol 14 issue 20
A study by Sathyanarayanan AR et al. entitled \"The on-task Attention of Individuals with Autism Spectrum Disorder-An Eye Tracker Study Using Auticare\" is awarded Best article of Vol 14 issue 19
A study by Gupta P. et al. entitled \"A Short Review on \"A Novel Approach in Fast Dissolving Film & their Evaluation Studies\" is awarded Best Article of Vol 14 issue 18.
A study by Shafaque M. et al. entitled \"A Case-Control Study Performed in Karachi on Inflammatory Markers by Ciprofloxacin and CoAmoxicillin in Patients with Chronic Suppurative Otitis Media\" is awarded Best Article of Vol 14 issue 17
A study by Ali Nawaz et al. entitled \"A Comparative Study of Tubeless versus Standard Percutaneous Nephrolithotomy (PCNL) \? A Randomized Controlled Study\" is awarded Best Article for Vol 14 issue 16.
A study by Singh R. et al. entitled \"A Prospective Study to Find the Association of Astigmatism in Patients of Vernal Keratoconjunctivitis (VKC) in a Tertiary Health Care Centre in India (Vindhya Region MP)\" is awarded Best Article for Vol 14 issue 15
A Study by Humaira Tahir et al. entitled "Comparison of First Analgesic Demand after Major Surgeries of Obstetrics and Gynecology between Pre-Emptive Versus Intra-Operative Groups by Using Intravenous Paracetamol: A Cross-Sectional Study" is awarded Best Article for Vol 14 issue 14
A Study by Monica K. entitled "Risk Predictors for Lymphoma Development in Sjogren Syndrome - A Systematic Review" is awarded Best Article for Vol 14 issue 13
A Study by Mokhtar M Sh et al. entitled "Prevalence of Hospital Mortality of Critically Ill Elderly Patients" is awarded Best Article for Vol 14 issue 12
A Study by Vidya S. Bhat et al. entitled "Effect of an Indigenous Cleanser on the Microbial Biofilm on Acrylic Denture Base - A Pilot Study" is awarded Best Article for Vol 14 issue 11
A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Tablet in Rodents" is awarded Best Article for Vol 14 issue 10
A Study by Muhammad Zaki et al. entitled "Effect of Hemoglobin Level on the Severity of Acute Bronchiolitis in Children: A Case-Control Study" is awarded Best Article for Vol 14 issue 09
A Study by Vinita S & Ayushi S entitled "Role of Colour Doppler and Transvaginal Sonography for diagnosis of endometrial pathology in women presenting with Abnormal Uterine Bleeding" is awarded Best Article for Vol 14 issue 08
A Study by Prabhu A et al. entitled "Awareness of Common Eye Conditions among the ASHA (Accredited Social Health Activist) Workers in the Rural Communities of Udupi District- A Pilot Study" is awarded Best Article for Vol 14 issue 07
A Study by Divya MP et al. entitled "Non-Echoplanar Diffusion-Weighted Imaging and 3D Fiesta Magnetic Resonance Imaging Sequences with High Resolution Computed Tomography Temporal Bone in Assessment and Predicting the Outcome of Chronic Suppurative Otitis Media with Cholesteatoma" is awarded Best Article for Vol 14 issue 06
A Study by Zahoor Illahi Soomro et al. entitled "Functional Outcomes of Fracture Distal Radius after Fixation with Two Different Plates: A Retrospective Comparative Study" is awarded Best Article for Vol 14 issue 05
A Study by Ajai KG & Athira KN entitled "Patients’ Gratification Towards Service Delivery Among Government Hospitals with Particular Orientation Towards Primary Health Centres" is awarded Best Article for Vol 14 issue 04
A Study by Mbungu Mulaila AP et al. entitled "Ovarian Pregnancy in Kindu City, D.R. Congo - A Case Report" is awarded Best Article for Vol 14 issue 03
A Study by Maryam MJ et al. entitled "Evaluation Serum Chemerin and Visfatin Levels with Rheumatoid Arthritis: Possible Diagnostic Biomarkers" is awarded Best Article for Vol 14 issue 02
A Study by Shanthan KR et al. entitled "Comparison of Ultrasound Guided Versus Nerve Stimulator Guided Technique of Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries" is awarded Best Article for Vol 14 issue 01
A Study by Amol Sanap et al. entitled "The Outcome of Coxofemoral Bypass Using Cemented Bipolar Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fracture of Femur in a Rural Setup" is awarded Best Article Award of Vol 13 issue 24
A Study by Manoj KP et al. entitled "A Randomized Comparative Clinical Trial to Know the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block Against Multimodal Analgesia for Postoperative Analgesia Following Caesarean Section" is awarded Best Article Award of Vol 13 issue 23
A Study by Karimova II et al. entitled "Changes in the Activity of Intestinal Carbohydrases in Alloxan-Induced Diabetic Rats and Their Correction with Prenalon" is awarded Best Article of Vol 13 issue 22
A Study by Ashish B Roge et al. entitled "Development, Validation of RP-HPLC Method and GC MS Analysis of Desloratadine HCL and It’s Degradation Products" is awarded Best Article of Vol 13 issue 21
A Study by Isha Gaurav et al. entitled "Association of ABO Blood Group with Oral Cancer and Precancer – A Case-control Study" is awarded Best Article for Vol 13 issue 20
A Study by Amr Y. Zakaria et al. entitled "Single Nucleotide Polymorphisms of ATP-Binding Cassette Gene(ABCC3 rs4793665) affect High Dose Methotrexate-Induced Nephrotoxicity in Children with Osteosarcoma" is awarded Best Article for Vol 13 issue 19
A Study by Kholis Ernawati et al. entitled "The Utilization of Mobile-Based Information Technology in the Management of Dengue Fever in the Community Year 2019-2020: Systematic Review" is awarded Best Article for Vol 13 issue 18
A Study by Bhat Asifa et al. entitled "Efficacy of Modified Carbapenem Inactivation Method for Carbapenemase Detection and Comparative Evaluation with Polymerase Chain Reaction for the Identification of Carbapenemase Producing Klebsiella pneumonia Isolates" is awarded Best Article for Vol 13 issue 17
A Study by Gupta R. et al. entitled "A Clinical Study of Paediatric Tracheostomy: Our Experience in a Tertiary Care Hospital in North India" is awarded Best Article for Vol 13 issue 16
A Study by Chandran Anand et al. entitled "A Prospective Study on Assessment of Quality of Life of Patients Receiving Sorafenib for Hepatocellular Carcinoma" is awarded Best article for Vol 13 issue 15
A Study by Rosa PS et al. entitled "Emotional State Due to the Covid – 19 Pandemic in People Residing in a Vulnerable Area in North Lima" is awarded Best Article for Vol 13 issue 14
A Study by Suvarna Sunder J et al. entitled "Endodontic Revascularization of Necrotic Permanent Anterior Tooth with Platelet Rich Fibrin, Platelet Rich Plasma, and Blood Clot - A Comparative Study" is awarded Best Article for Vol 13 issue 13
A Study by Mona Isam Eldin Osman et al. entitled "Psychological Impact and Risk Factors of Sexual Abuse on Sudanese Children in Khartoum State" is awarded Best Article for Vol 13 issue 12
A Study by Khaw Ming Sheng & Sathiapriya Ramiah entitled "Web Based Suicide Prevention Application for Patients Suffering from Depression" is awarded Best Article for Vol 13 issue 11
A Study by Purushottam S. G. et al. entitled "Development of Fenofibrate Solid Dispersions for the Plausible Aqueous Solubility Augmentation of this BCS Class-II Drug" is awarded Best article for Vol 13 issue 10
A Study by Kumar S. et al. entitled "A Study on Clinical Spectrum, Laboratory Profile, Complications and Outcome of Pediatric Scrub Typhus Patients Admitted to an Intensive Care Unit from a Tertiary Care Hospital from Eastern India" is awarded Best Article for Vol 13 issue 09
A Study by Mardhiah Kamaruddin et al. entitled "The Pattern of Creatinine Clearance in Gestational and Chronic Hypertension Women from the Third Trimester to 12 Weeks Postpartum" is awarded Best Article for Vol 13 issue 08
A Study by Sarmila G. B. et al. entitled "Study to Compare the Efficacy of Orally Administered Melatonin and Clonidine for Attenuation of Hemodynamic Response During Laryngoscopy and Endotracheal Intubation in Gastrointestinal Surgeries" is awarded Best Article for Vol 13 issue 07
A Study by M. Muthu Uma Maheswari et al. entitled "A Study on C-reactive Protein and Liver Function Tests in Laboratory RT-PCR Positive Covid-19 Patients in a Tertiary Care Centre – A Retrospective Study" is awarded Best Article of Vol 13 issue 06 Special issue Modern approaches for diagnosis of COVID-19 and current status of awareness
A Study by Gainneos PD et al. entitled "A Comparative Evaluation of the Levels of Salivary IgA in HIV Affected Children and the Children of the General Population within the Age Group of 9 – 12 Years – A Cross-Sectional Study" is awarded Best Article of Vol 13 issue 05 Special issue on Recent Advances in Dentistry for better Oral Health
A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" is awarded Best Article of Vol 13 issue 06
A Study by Chen YY and Ghazali SRB entitled "Lifetime Trauma, posttraumatic stress disorder Symptoms and Early Adolescence Risk Factors for Poor Physical Health Outcome Among Malaysian Adolescents" is awarded Best Article of Vol 13 issue 04 Special issue on Current Updates in Plant Biology to Medicine to Healthcare Awareness in Malaysia
A Study by Kumari PM et al. entitled "Study to Evaluate the Adverse Drug Reactions in a Tertiary Care Teaching Hospital in Tamilnadu - A Cross-Sectional Study" is awarded Best Article for Vol 13 issue 05
A Study by Anu et al. entitled "Effectiveness of Cytological Scoring Systems for Evaluation of Breast Lesion Cytology with its Histopathological Correlation" is awarded Best Article of Vol 13 issue 04
A Study by Sharipov R. Kh. et al. entitled "Interaction of Correction of Lipid Peroxidation Disorders with Oxibral" is awarded Best Article of Vol 13 issue 03
A Study by Tarek Elwakil et al. entitled "Led Light Photobiomodulation Effect on Wound Healing Combined with Phenytoin in Mice Model" is awarded Best Article of Vol 13 issue 02
A Study by Mohita Ray et al. entitled "Accuracy of Intra-Operative Frozen Section Consultation of Gastrointestinal Biopsy Samples in Correlation with the Final Histopathological Diagnosis" is awarded Best Article for Vol 13 issue 01
A Study by Badritdinova MN et al. entitled "Peculiarities of a Pain in Patients with Ischemic Heart Disease in the Presence of Individual Combines of the Metabolic Syndrome" is awarded Best Article for Vol 12 issue 24
A Study by Sindhu Priya E S et al. entitled "Neuroprotective activity of Pyrazolone Derivatives Against Paraquat-induced Oxidative Stress and Locomotor Impairment in Drosophila melanogaster" is awarded Best Article for Vol 12 issue 23
A Study by Habiba Suhail et al. entitled "Effect of Majoon Murmakki in Dysmenorrhoea (Usre Tams): A Standard Controlled Clinical Study" is awarded Best Article for Vol 12 issue 22
A Study by Ghaffar UB et al. entitled "Correlation between Height and Foot Length in Saudi Population in Majmaah, Saudi Arabia" is awarded Best Article for Vol 12 issue 21
A Study by Siti Sarah Binti Maidin entitled "Sleep Well: Mobile Application to Address Sleeping Problems" is awarded Best Article for Vol 12 issue 20
A Study by Avijit Singh"Comparison of Post Operative Clinical Outcomes Between “Made in India” TTK Chitra Mechanical Heart Valve Versus St Jude Mechanical Heart Valve in Valve Replacement Surgery" is awarded Best Article for Vol 12 issue 19
A Study by Sonali Banerjee and Mary Mathews N. entitled "Exploring Quality of Life and Perceived Experiences Among Couples Undergoing Fertility Treatment in Western India: A Mixed Methodology" is awarded Best Article for Vol 12 issue 18
A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09

List of Awardees

A Study by Ese Anibor et al. "Evaluation of Temporomandibular Joint Disorders Among Delta State University Students in Abraka, Nigeria" from Vol 13 issue 16 received Emerging Researcher Award


A Study by Alkhansa Mahmoud et al. entitled "mRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells" from Vol 13 issue 06 received Emerging Researcher Award


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Disclaimer: International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal.



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International Journal of Current Research and Review (IJCRR) provides platform for researchers to publish and discuss their original research and review work. IJCRR can not be held responsible for views, opinions and written statements of researchers published in this journal

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