International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 05 Issue 07, April, 2013

Pages: 84-87

Date of Publication: 18-Apr-2013


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DOPING IN SPORTS: CURRENT REVIEW

Author: Motilal C. Tayade, Sunil M. Bhamare, Prathamesh Kamble, Kirankumar Jadhav

Category: Healthcare

Abstract:Nowadays doping is critical issue at International level in sport Physiology. This is not only concerned with health matter but also with the moral as well as ethical values of humanity affecting honest team spirit of sports competition. This is directly affecting sports, competitions around the world. Blood doping is the misuse of specific substances to increase one's red blood cell mass, which allows the body to transport more oxygen to muscles and therefore increase performance and stamina of player or person. There are seen a list numbers of life threatening side effects occurred as a result of blood doping like increases in blood viscosity, myocardial infarction, embolism, stroke, infections, allergic reactions and certain risk of blood born disease like HIV,Hepatitis etc. Anti-doping policies instituted by individual sporting governing bodies may conflict with local laws. There is no such correlation between these authorities and government laws. Nowadays there are a numbers of techniques as well as drugs are using by players, which is really a challenge to detect them by experts and fight the war against doping. However it is our responsibility to fight against them, with update of knowledge and events.

Keywords: Doping, Erythropoietin, Sport Physiology, Antidoping policies

Full Text:

INTRODUCTION

Nowadays doping is critical issue at International level in sport Physiology. This is not only concerned with health matter but also with the moral as well as ethical values of humanity affecting honest team spirit of sports competition. This is directly affecting sports, competitions around the world. Initially term ‘doping’ was restricted only with blood doping. But today the area of doping increases in such a way that the available tests become helpless for doping detection. However avoidance of doping is necessity and duty of experts by updating their knowledge in this field. Any form of practices leading to use of specific drugs with an objective to improve performance or stamina in sport can be referred as Doping. This is considering as unethical by respective organizations where such incidences are repetitively occurring either at National as well as International level. International Olympic committee declares this issue as unlawful and unethical. These committees often charges regular serious actions against such events occurred by time to time. This organization always tries extreme efforts for Doping free sports. 1 Doping is widely used by sportspersons in an attempt to improve their performance without any fear or unawareness related to their consequences or side effects. These practices not only hampers the quality of sports but it may be consider as one part as corruption in sports, thus affecting sport spirit.2 Blood doping is the misuse of specific substances to increase one's red blood cell mass, which allows the body to transport more oxygen to muscles and therefore increase performance and stamina of player or person. This can be achieving either by direct use of either erythropoietin (EPO), synthetic oxygen carriers or direct blood transfusions. The first documented organized doping controls were carried out in the 1970s. In 1993, the Czech Antidoping Charter was signed and the Antidoping Committee was established. The medical commission of International Olympic Committee decides and declares regularly, which substances and methods are should be prohibited.3

DOPING FORMS
1. Hormone abuse in sports :
steroidal and peptide hormones and their modulators, stimulants, glucocorticosteroids, beta2- agonists, diuretics and masking agents, narcotics, and cannabinoids all these, hormones constitute by far the highest number of adverse analytical findings reported by antidoping laboratories.3

2. Blood doping: Blood doping is systemically defined by WADA (World Anti-Doping Agency) as the misuse of techniques and/or substances to increases ones red blood cell count. 4 It is used by either autologus ways or Homologus ways. Most commonly this involves the removal of two units of the athletes blood several weeks prior to competition. The blood is then frozen until 1- 2 days before the competition, when it is thawed and injected back into the athlete. This is known as autologous blood doping. Homologous doping is the injection of fresh blood, removed from a second person, straight into the athlete. 1

3. Use of Artificial Oxygen Carriers: A second method of blood doping involves the use of artificial oxygen carriers. Hemoglobin oxygen carriers (HBOC's) and Perfluorocarbons (PFC's) are chemicals or purified proteins which have the ability to carry oxygen. They have been developed for therapeutic use, however are now being misused as performance enhancer's.

Medical Uses of Blood Doping: Artificial Oxygen carriers are the only form of blood doping have important medical use. They were developed for use in emergencies when there is no time for determining and cross-matching a patients blood-type for transfusion, when there is a high risk of infection, or simply when no blood is available.

DISCUSION

Blood doping is most commonly used by endurance athletes, such as distance runners, skiers and cyclists. By increasing the number of red blood cells within the blood , higher volumes of the protein haemoglobin are present. Haemoglobin binds to and carries Oxygen from the lungs, to the muscles where it can be used for aerobic respiration. Blood doping therefore allows extra Oxygen to be transported to the working muscles, resulting in a higher level of performance, without the use of the anaerobic energy systems. Several Studies have shown that blood doping can improve the performance of endurance athletes.5

Side Effects of Blood Doping : There are seen a list numbers of life threatening side effects occurred as a result of blood doping like increases in blood viscosity, myocardial infarction, embolism, stroke, infections, allergic reactions and certain risk of blood born disease like HIV,Hepatitis etc.

Erythropoietin and Blood doping: Erythropoietin (EPO) is a naturally occurring hormone, secreted mainly by the kidneys, which plays an important role in the regulation of production of red blood cells. The use of EPO started in the 1980's as a quicker, cleaner alternative to blood doping. Testing for EPO only became possible after 2000. Testing may be done by using both blood and urine sample. Erythropoietin is mainly use by endurance athletes such as long distance runners and cyclists.3

Physiology of Erythropoietin: EPO stimulates bone marrow to produce more red blood cells and therefore haemoglobin. For this reason EPO is most commonly used amongst endurance athletes as a higher RBC count means better oxygen transportation and so a higher rate of aerobic respiration. The faster the rate of aerobic respiration, the higher the level at which the athlete can work without utilising the anaerobic systems which produce lactic acid and cause fatigue Side effects of Erythropoietin: There is found major side-effects of using erythropoietin which have proven to be fatal. These are dangerous due to increases in viscosity of blood leads to fever, seizers, nausea, anxiety, lethargy etc.

Doping and Law:
1. There are certain laws concerned with punishment in an event occur by sport person. However due to worldwide lack of any uniform policies, doping was leading as Local issue. This is a major drawback in putting applications of strict antidoping laws.

2. Anti-doping policies instituted by individual sporting governing bodies may conflict with local laws. There is no such correlation between these authorities and government laws.

3. Athletes caught in doping may be subject only to penalties from their locality as well from the individual sporting governing body. The body has a only right to bar the player from their association. However these players may continue their carrier through other routes due to lack of uniformity.

Doping and India
A Zee Research Group analysis released in October 2012 states the fact, doping associated with performance enhancing drugs badly affecting moral, ethical foundations and spirit of competitiveness in modern sports. Sports across the world including India at some or the other point have suffered from doping matter.6 Bangalore based National Anti-Doping Agency (NADA) has introduced blood sampling and testing in India, with the kabaddi World Cup, in 2010.7 In India, the awareness concerned with doping increasing at International as well as National level sports. This is a promising facts noted in Indian doctors, players as well as in officers.

4. The legal status of anabolic steroids varies from country to country.

5. These limitations hamper the strictness concern with such serious issue.

Doping – New challenges:
Recently German doping specialist Mario Thevis explained more than 100 certain undetectable performance enhancing drugs. According to him these are very difficult to detect due to their structural characteristics.8 It is very difficult to develop tests against these drugs.

CONCLUSION

Nowadays there are a numbers of techniques as well as drugs are using by players, which is really a challenge to detect them by experts and fight the war against doping. However it is our responsibility to fight against them, with update of knowledge and events.

ACKNOWLEDGEMENT

Authors acknowledge the great help received from the scholars whose articles cited and included in references of this manuscript. The authors are also grateful to authors / editors / publishers of all those articles, journals and books from where the literature for this article has been reviewed and discussed. Authors are grateful to IJCRR editorial board members and IJCRR team of reviewers who have helped to bring quality to this manuscript.

References:

1. Teach PE: http://www.teachpe.com/drugs/epo.php ; Downloaded on 14/12/2012

2. Belson, Ken , N.F.L. Seeks Congressional Help on Drug Policy, The New YorkTimes,(2009-11-04). http://www.nytimes.com/2009/11/04/sports/f ootball/04starcaps.html?_r=1andhpw. Retrieved 2010-05-27.

3. Jeschke J, Nekola J, Chlumský J.Doping in sports. Cas Lek Cesk. 1999 May 10;138(10):291-7.

4. Hartgens F.Medication, athletes and doping regulations. Ned Tijdschr Geneeskd. 2008 Aug 16;152(33):1844-8.

5. Lippi G, Guidi G.Doping and sports. Minerva Med. 1999 Sep;90(9):345-57.

6. Zee Research Group report. The curse of doping in sports. Tuesday, Oct 16, 2012, 21:41 IST Place: New Delhi | Agency: Zee Research Group. http://www.dnaindia.com/india/report_thecurse-of-doping-in-sports_1753162

7. TNN, NADA to crack down on blood doping. Times of India; 17 April 2010. http://articles.timesofindia.indiatimes.com/20 10-04-07/others/28117471_1_blood-dopingnada-samples;downloaded on 03/01/2013.

8. John Mehaffey. Doping-Undetectable new blood boosters available says expert. Olympycs 2012, Reutuers Edition US; http://www.reuters.com/article/2012/03/15/do ping-epo idUSL4E8EF70520120315; Downloaded on 03/01/2013.

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Best Article Award

A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma COLAKOGLU entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by Arpita M. et al entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09
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List of Awardees

Awardees of COVID-19 Research

Woman Researcher Award

A Study by Neha Garg et al. entitled "Optimization of the Response to nCOVID-19 Pandemic in Pregnant Women – An Urgent Appeal in Indian Scenario" published in Vol 12 issue 09

A Study by Sana Parveen and Shraddha Jain entitled "Pathophysiologic Enigma of COVID-19 Pandemic with Clinical Correlates" published in Vol 12 issue 13

A Study by Rashmi Jain et al. entitled "Current Consensus Review Article on Drugs and Biologics against nCOVID-19 – A Systematic Review" published in Vol 12 issue 09

Emerging Researcher Award

A Study by Madhan Jeyaraman et al. entitled "Vitamin-D: An Immune Shield Against nCOVID-19" published in Vol 12 issue 09

Study by Dheeraj Kumar Chopra et al. entitled "Lipid-Based Solid Dispersions of Azilsartan Medoxomil with Improved Oral Bioavailability: In Vitro and In Vivo Evaluation" published in Vol 12 issue 19


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