International Journal of Current Research and Review
ISSN: 2231-2196 (Print)ISSN: 0975-5241 (Online)
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IJCRR - Vol 05 Issue 15 , August, 2013

Pages: 6-11

Date of Publication: 17-Aug-2013

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Author: Dattatray Dombe, Takkallapalli Anitha, Sanjay Kalbande, Thaduri Naresh

Category: Healthcare

Abstract:Background: Accurate knowledge of coronary ostia is not only important for anatomists but also for radiologists and intervention cardiologists performing angiographies and shunt surgeries. The high prevalence, morbidity, mortality and enormous socioeconomic burden of coronary artery disease, has necessitated us to take up this study. We have made a sincere attempt to describe the normal and variant anatomy of the coronary ostia in 64 cadaveric hearts of Indian origin. The origin of coronary arteries, the number of coronary ostia, their location in relation to sinotubular junction and the diameter of coronary ostia were observed and their clinical implications are discussed. Aim: To study the variations in number, location of coronary ostia in aortic sinuses and measuring their diameter. Methodology: Sixty four cadaveric hearts with great vessels attached were analyzed in this study. The ascending aorta cut longitudinally at the posterior aortic sinus to visualize right and left posterior aortic sinus for analysis. Results: In all 64 heart specimens right coronary ostia was present in anterior aortic sinus and left coronary ostia in left posterior aortic sinus. Multiple coronary ostia were noted in 18.7% of cases. Conclusion: The great importance of coronary catheterization for diagnostic and therapeutic purposes has currently motivated the present study.

Keywords: Coronary arteries, Coronary ostia, Aortic sinuses, Anomalous.

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Coronary catheterization for diagnostic and therapeutic purposes has assumed significance in recent times, as the incidence of coronary artery diseases has seen an increasing trend in developing countries in the last few decades. Considering the hypothesis formulated by some authors [1,2] that changes in coronary flow may be due to changes in diameter, position and anatomic relations of the coronary ostia, this study provides data regarding the variations of coronary ostial origins, emphasizing the importance of such anatomic variants in the development of treatment.

In the vast majority of people, there are two main coronary arteries, right and left, which arise from separate ostia in the aorta. The bulbar aortic sinus and the proximal ascending aorta comprise the aortic root. A slight circumferential thickening, known as the sinotubular ridge (sinotubular junction) marks the separation of these two structures. The bulbous sinus and the three aortic cusps merge to form the sinuses of valsalva. The right sinus of valsalva lies right and anterior in the aortic root and contain the right aortic semilunar cusp, where as the left sinus of valsalva lies left and posterior in the aortic root and contains the left aortic semilunar cusp. The posterior sinus of valsalva lies posterior to the right sinus and contains the non coronary aortic semilunar cusp [3].

The coronary ostia are usually located below the sinotubular ridge within the sinus of valsalva, centrally located between the commissural attachments of the aortic cusps [4]. The ostium of each coronary artery tends to form a slight funnel, with the diameter of the left main coronary artery at its ostium slightly larger than that of the right coronary artery (mean 4.0 versus 3.2mm) [5].


64 formalin fixed cadaveric hearts with their great vessels attached were used in this study, which was carried out in the department of Anatomy at Chalmeda Anandrao Institute of Medical Sciences, Bommakal, Karimnagar, India, over a period of 3 years i.e. 2010 to 2013. The hearts were dissected, the pericardium involving the root of the aorta was removed, and the origin of the right and left coronary arteries was isolated. Then, the ascending aorta was sectioned approximately 3cm above the commissures of the aortic leaflets. Next, the aorta was longitudinally opened at the level of posterior aortic sinus (non coronary sinus) to enable the visualization and analysis of the right and left aortic leaflets and their respective coronary ostia. In addition, the coronary arteries were sectioned at the level of their origins in the aortic wall (Juxta mural portion of the coronary arteries). The coronary ostia in relation to the right and left aortic leaflets were identified. The origin of coronary arteries, number of coronary ostia, their location in relation to the sinotubular junction and the diameter of coronary ostia using the vernier caliper were noted and tabulated.


The following criteria have been taken into consideration

1) Origin of right and left coronary arteries.

2) Number of coronary ostia in various aortic sinuses.

3) Location of right and left coronary ostia in relation to sinotubular junction.

4) Diameter of right and left coronary ostia.



The morphometric and topographical analysis of coronary ostia have been implicated in various clinical conditions and awareness of these anatomical variants may decrease the morbidity and mortality associated with various invasive procedures.

The aortic root is a frequent site of interventional procedures in both adults and children. Understanding the precise nature and relation of the anatomical structures composing the aortic root including coronary orifices is valuable in percutaneous and transcatheter therapeutic techniques for valve or device implantations as well as in various open heart procedures [6].

The origin of coronary artery is an important parameter in cardiac procedures. A single coronary artery occurs in 0.024% of people. It is usually benign but may be associated with congenital heart disease, such as transposition of the great arteries, tetralogy of Fallot, truncus arteriosus and coronary artery fistula [7]. Despite the anomalous origin, the peripheral coronary artery distribution is usually normal. This entity can be mistaken for two separate ostia originating from the same sinus of valsalva or for artesia of coronary ostium [8]. In 25% of patients with a single coronary artery, a major branch crosses the infundibulum, which can not only cause chest pain, myocardial infarction or sudden death but also has technical implications for the surgeon when exposing the heart, instituting extracorporeal circulation or when performing a right ventriculotomy.

The origin of right and left coronary arteries from the anterior aortic and left posterior aortic sinuses respectively is 100% in the present study and matches the standard books of anatomy[9] [Table No.1].

Presence of multiple anomalous ostia is rare and could cause certain clinical consequences. An abnormal location or an accessory origin of the coronary orifices may disturb performing an aortotomy incision for aortic exposure, preparing a coronary button in root replacement, direct delivery of cardioplegia through the coronary orifices and approach for aortic root enlargement [5].

Solitary coronary ostium giving rise to solitary coronary arteries can be a substrate for sudden cardiac death and carries the potential to precipitate severe ischaemic heart disease, including myocardial infarction in younger patients [10]. However, we could not find a solitary coronary ostium in the present study [Table No: 2].  

When multiple ostia are observed in the anterior aortic sinus, the most common variation observed is an accessory orifice for right conus artery [11]. The third coronary artery usually forms an anastomosis with the likewise branch of left coronary artery. This anastomosis lies on the distal part of the pulmonary trunk and is known as the “vieussens arterial ring”. This may serve as collateral path between the right and left coronary arteries. Similar observation was made in our present study where 2 ostia arose from anterior aortic sinus in 11 cases (Fig: 2)  [Table No. 2]. 

In approximately 8% of hearts, the openings were three or more in number. In such cases, one of the extra ostia may be that of SA nodal artery. In 50% of cases, the SA nodal artery arises as a branch of the initial part of the right coronary artery [11]. In the present study, three coronary ostia were seen in anterior aortic sinus in 2 cases. One heart had 3 separate ostia in the anterior aortic sinus for the right coronary, right conus artery and a vasa vasorum to the pulmonary trunk.

The present study reports 4 separate ostia (Fig: 3) in the anterior aortic sinus of a single heart. One of the ostia was for the right coronary and the three accessory ostia were for the right conus and SA nodal arteries and vasa vasorum to the pulmonary trunk [Table No.2].

Presence of multiple ostia is a hazard to heart surgeries as the ostia of small arteries like third coronary artery are usually very small and barely get opacified in angiographies, thus these arteries miss detection preoperatively and can get nicked during surgery [12].

The preoperative knowledge of location of coronary ostia in relation to sinotubular junction is important in the management of patients with different pathologies involving the aortic root and coronary arteries. Alexander et al [13] stated that the right and left coronary ostia arise normally within the aortic sinuses or at the junction of sinus and tubular portions of aorta. Such a location of ostium allows maximal coronary filling during ventricular diastole. Alexander described a record position of ‘High take off coronary artery’ as 2.5cm above the sinoaortic junction. The detection of such high originating coronary arteries is clinically significant because it can decrease the diastolic coronary arterial filling and such arteries can be missed while performing procedures like coronary angiography.

Vlodover et al [14] stated that both the coronary ostia were observed above the sinotubular ridge in 6% of randomly selected hearts. This becomes important to the operator attempting to perform coronary angiography, where selective intubation of the anomalous vessel may be extremely difficult, especially in the case of the right coronary artery with a high anterior ostium.

In our present study 3.1% of cases of both right and left coronary ostia were above the sinotubular junction [Table No.3].

The diameter of coronary ostia is also significant. The proximal segment of each coronary artery is intramural; it courses through the aortic wall and is usually tapered or funnel shaped. Jenny sales cavalcanti et. al. [15] reported 16% reduction in juxta mural diameter of RCA compared to the ostial diameter and in LCA the reduction was 11%. This needs to be considered when designing stents for aorto-ostial coronary lesion in order to achieve optimal results avoiding retrograde aorto coronary dissection and reducing restenosis. The smaller dimension of some coronary artery segments has important diagnostic and therapeutic implications since for any interventional procedure the absolute size of the coronary artery matters.

It has been reported that occlusion or thrombosis is more common in vessels less than 2.5mm in diameter. A moderate (60%) stenosis in a 2.5mm vessel would have more effects on flow than the same degree of stenosis in a 3.5mm vessel as the cross sectional area in the former would be reduced to 1.76mm2 as compared to 3.46mm2 in a larger vessel. Thus a moderate plaque would cause significant implications in coronary revascularization.

In our present study, the mean ostial diameter of left coronary artery was larger than right coronary artery [Table No. 4].


Accurate knowledge of the locations of the coronary ostia in relation to the aortic root is critical for a number of interventional and surgical cardiovascular procedures, including cannulation or catheterization of the coronary arteries, aortic graft repair or root replacement and implantation of percutaneous aortic valves or transapical replacement. The recent advent of percutaneous aortic valves, providing a non-operative treatment of symptomatic aortic valve disease has necessitated continuing development of device, techniques and treatment protocols for optimization of percutaneous aortic valve procedures [16]. With the proximity of the coronary ostia to the aortic annulus and valve leaflets, a particularly challenging issue is the risk of obstruction of the coronary ostia during percutaneous aortic valve replacement.

Concerning percutaneous and transapical valve replacement, obstruction of the coronary arteries during and/or after implantation remains a risk that can have catastrophic consequences. Boudjemline and Bonhoeffer [17] point out that precise placement, with respect to height of percutaneous aortic valve is crucial. Locations too high above the valve annulus result in coronary ostial obstruction and locations too low can negatively impact left ventricular and/or mitral valve function.


Knowledge of variants in coronary anatomy is important as failure to recognize these anomalies may at times create challenges during radio diagnostic, various invasive and operative cardiac procedures.


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Research Incentive Schemes

Awards, Research and Publication incentive Schemes by IJCRR

Best Article Award: 

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJCRR Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJCRR. Women researcher, who intends to publish her research work in IJCRR as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJCRR’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJCRR. Student researchers, who intend to publish their research or review work in IJCRR as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to for more details.

Best Article Award

A Study by Jabbar Desai et al. entitled "Prevalence of Obstructive Airway Disease in Patients with Ischemic Heart Disease and Hypertension" is awarded Best Article for Vol 12 issue 17
A Study by Juna Byun et al. entitled "Study on Difference in Coronavirus-19 Related Anxiety between Face-to-face and Non-face-to-face Classes among University Students in South Korea" is awarded Best Article for Vol 12 issue 16
A Study by Sudha Ramachandra & Vinay Chavan entitled "Enhanced-Hybrid-Age Layered Population Structure (E-Hybrid-ALPS): A Genetic Algorithm with Adaptive Crossover for Molecular Docking Studies of Drug Discovery Process" is awarded Best article for Vol 12 issue 15
A Study by Varsha M. Shindhe et al. entitled "A Study on Effect of Smokeless Tobacco on Pulmonary Function Tests in Class IV Workers of USM-KLE (Universiti Sains Malaysia-Karnataka Lingayat Education Society) International Medical Programme, Belagavi" is awarded Best article of Vol 12 issue 14, July 2020
A study by Amruta Choudhary et al. entitled "Family Planning Knowledge, Attitude and Practice Among Women of Reproductive Age from Rural Area of Central India" is awarded Best Article for special issue "Modern Therapeutics Applications"
A study by Raunak Das entitled "Study of Cardiovascular Dysfunctions in Interstitial Lung Diseas epatients by Correlating the Levels of Serum NT PRO BNP and Microalbuminuria (Biomarkers of Cardiovascular Dysfunction) with Echocardiographic, Bronchoscopic and HighResolution Computed Tomography Findings of These ILD Patients" is awarded Best Article of Vol 12 issue 13 
A Study by Kannamani Ramasamy et al. entitled "COVID-19 Situation at Chennai City – Forecasting for the Better Pandemic Management" is awarded best article for  Vol 12 issue 12
A Study by Muhammet Lutfi SELCUK and Fatma COLAKOGLU entitled "Distinction of Gray and White Matter for Some Histological Staining Methods in New Zealand Rabbit's Brain" is awarded best article for  Vol 12 issue 11
A Study by Anamul Haq et al. entitled "Etiology of Abnormal Uterine Bleeding in Adolescents – Emphasis Upon Polycystic Ovarian Syndrome" is awarded best article for  Vol 12 issue 10
A Study by Arpita M. et al entitled "Estimation of Reference Interval of Serum Progesterone During Three Trimesters of Normal Pregnancy in a Tertiary Care Hospital of Kolkata" is awarded best article for  Vol 12 issue 09
A Study by Ilona Gracie De Souza & Pavan Kumar G. entitled "Effect of Releasing Myofascial Chain in Patients with Patellofemoral Pain Syndrome - A Randomized Clinical Trial" is awarded best article for  Vol 12 issue 08
A Study by Virendra Atam et. al. entitled "Clinical Profile and Short - Term Mortality Predictors in Acute Stroke with Emphasis on Stress Hyperglycemia and THRIVE Score : An Observational Study" is awarded best article for  Vol 12 issue 07
A Study by K. Krupashree et. al. entitled "Protective Effects of Picrorhizakurroa Against Fumonisin B1 Induced Hepatotoxicity in Mice" is awarded best article for issue Vol 10 issue 20
A study by Mithun K.P. et al "Larvicidal Activity of Crude Solanum Nigrum Leaf and Berries Extract Against Dengue Vector-Aedesaegypti" is awarded Best Article for Vol 10 issue 14 of IJCRR
A study by Asha Menon "Women in Child Care and Early Education: Truly Nontraditional Work" is awarded Best Article for Vol 10 issue 13
A study by Deep J. M. "Prevalence of Molar-Incisor Hypomineralization in 7-13 Years Old Children of Biratnagar, Nepal: A Cross Sectional Study" is awarded Best Article for Vol 10 issue 11 of IJCRR
A review by Chitra et al to analyse relation between Obesity and Type 2 diabetes is awarded 'Best Article' for Vol 10 issue 10 by IJCRR. 
A study by Karanpreet et al "Pregnancy Induced Hypertension: A Study on Its Multisystem Involvement" is given Best Paper Award for Vol 10 issue 09
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Awardees of COVID-19 Research

Woman Researcher Award

A Study by Neha Garg et al. entitled "Optimization of the Response to nCOVID-19 Pandemic in Pregnant Women – An Urgent Appeal in Indian Scenario" published in Vol 12 issue 09

A Study by Sana Parveen and Shraddha Jain entitled "Pathophysiologic Enigma of COVID-19 Pandemic with Clinical Correlates" published in Vol 12 issue 13

A Study by Rashmi Jain et al. entitled "Current Consensus Review Article on Drugs and Biologics against nCOVID-19 – A Systematic Review" published in Vol 12 issue 09

Emerging Researcher Award

A Study by Madhan Jeyaraman et al. entitled "Vitamin-D: An Immune Shield Against nCOVID-19" published in Vol 12 issue 09

Study by Dheeraj Kumar Chopra et al. entitled "Lipid-Based Solid Dispersions of Azilsartan Medoxomil with Improved Oral Bioavailability: In Vitro and In Vivo Evaluation" published in Vol 12 issue 19

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