Back ground and Objective: Bacterial vaginosis (BV) is a polymicrobial syndrome having alteration of vaginal flora involving a decrease in Lactobacilli and predominance of anaerobic bacteria. Objective was to evaluate the efficacy of the Bark of Acacia arabica (chal babool) as an alternate therapy in the management of Bacterial Vaginosis. Methodology: This was a prospective, single blind, standard controlled randomized clinical trial on 45 patients (30 patients in test group and 15 in control group) who attended in and outpatient Department of OBG, National Institute of Unani Medicine hospital, Bangalore, India with complaint of abnormal vaginal discharge or vulvovaginal pruritus. Married patients aged 18- 45 years with regular cycles and diagnosed as having BV were included in this study. Patients were excluded if there was a blood stained discharge, any organic pelvic pathology, systemic illness, malignancy, AIDS, syphilis, gonorrhoea, pregnant and lactating women. Decoction of Chal babool was given orally (30gms twice daily) for one month and standard drug Tab. Metronidazole (400mg twice daily) for 7 days was given in test and control group respectively. For diagnosis and cure rate of bacterial vaginosis, Amsel__ampersandsignrsquo;s criteria were used. Results: There was a significant improvement in the subjective and objective parameters; test drug was found to have similar effective as in control drug in the management of Bacterial Vaginosis (P =1.000) statistically. Conclusion: Patients in both groups have shown improvement by treatment. This study confirms the efficacy of chal Babool as potent astringent and antimicrobial. Phase -3 clinical study shall be recommended with large sample size and prolonged duration.