Unani scholars managed certain ailments since antiquity by regulating the metabolic process through various modes of treatment. Ibnesina (Avicenna) has advocated certain principles of treatment. Regimenal therapy is one such core method of treatment through which the morbid matter is eliminated, its excessive production is checked or its spread is arrested and resolved by certain special techniques and there by restoring humoral equilibrium. One such procedure is Hijamat (Cupping).Hijamat is an Arabic word derived from the term ?Hajm__ampersandsignlsquo; which stands for volume, but technically used for sucking. It also means ?to minimize?, ?to restore to basic size? or ?to diminish the volume?.Neuralgic pains of lower limbs are one of the commonest manifestations of Irqunnasa (Sciatica). The overall incidence of this condition is projected to be between 13% and 40% with the malady has the potential to become chronic and obstinate with large socioeconomic ramifications. Irqunnasa is mostly managed by the mainstream therapists either by medication or surgical intervention or sometimes both. The consequence of evidence based medicine in terms of high cost, disease centric management and its associated side effects warrantsaviable alternative.A meticulous attempt has been made to explore the utility of this age old regimen in the management of Irqunnasa (sciatica).