Aim: Metabolic Syndrome has become one of the most severe health problems of the 21st century. In India, the overall prevalence of metabolic syndrome among adolescents is 4.2 per cent. World Wide Web has become indispensable and the most effective distribution channel in this era of digital technology and is convenient to use and capable of reaching adolescents. With this in view, the present study aimed to develop an interactive website on metabolic syndrome, impart nutrition education with the developed website and evaluate its impact on the nutritional knowledge of obese adolescent girls (16-18 years). Methodology: An informative, responsive website was developed with the domain name metabolicsyndrome-km.com. The website included information on metabolic syndrome, causes, symptoms, risk factors, criteria to diagnose metabolic syndrome, diet plan for adolescents with metabolic syndrome, basic food groups, recommended daily allowances, indicator of metabolic syndrome and body mass index calculations. Result: The website was developed using Hypertext Markup Language (HTML), Cascading Style Sheets (CSS) and Adobe Photoshop. The calculations and the questionnaire were computed using PHP: Hypertext Preprocessor and JavaScript. The software applications used to create HTML for the nutrition website was Dreamweaver. Discussion: Obese adolescent girls (198) were educated and instructed to visit the developed metabolic syndrome website and changes in their nutritional knowledge and was evaluated. The nutritional knowledge attained through the website was evaluated by using a control panel with username and password url in which the viewers posted their questionnaire. A significant increase in nutritional knowledge after imparting nutrition education among obese adolescent girls was observed (p__ampersandsignlt;0.01). Conclusion: The findings from this study provide a primary intervention strategy to increase awareness and promote healthy lifestyle among adolescents through advanced methods of nutrition education.