This is a descriptive / retrospective crosssectional study. This study was carried out at the histopathology laboratory, Department of Pathology, B. J. Medical College, Ahmedabad from January 2008 to December 2009 on all splenecand tomy specimens and one splenculi biopsy. Total 200 cases were studied which were received already fixed in 10% neutral buffer formalin. Among the specimens the most common age group fell in 21-30 years (30%). Male to female sex ratio was1:1.1. In 30% cases cause of splenomegaly was not identified. Most common known cause for splenomegaly was portal hypertension (23.5%) followed by trauma (12.5%). Most common diagnosis made after microscopy and correlating clinical and radiological findings was fibrocongestive splenomegaly (67%), which was most commonly due to hepatic cause. Most common cause identified later in unidentified cases of splenomegaly was also fibrocongestive splenomegaly (69%).