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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Radiance Research Academy</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">93</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url"/><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>Hematological and Bone Marrow Biopsy Evaluation in Non Hodgkin Lymphoma&#13;
</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kaur1</surname><given-names>Kanwalpreet</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sharma2</surname><given-names>Nidhi</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gupta3</surname><given-names>Karuna</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gulati4</surname><given-names>Sandhya</given-names></name></contrib><contrib contrib-type="author"><name><surname>Choudhary5</surname><given-names>Prerana</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>10</day><month>02</month><year>2017</year></pub-date><volume/><issue/><fpage>24</fpage><lpage>27</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>Aim: Bone marrow evaluationis an integral part of staging workup in patients with Non-Hodgkin__ampersandsignrsquo;s lymphoma (NHL). Aim of this study is to analyze incidence and histological pattern of bone marrow involvement in diagnosed cases of NHL.&#13;
Methodology: This is a retrospective study on 85 patients diagnosed with NHL. Bone marrow biopsy was performed under local anesthesia as a part of staging workup in cases of NHL. Complete blood counts (CBC) were also noted in each case.&#13;
Results: In this study, NHL cases comprised of low grade NHL 68.2%, intermediate grade 28.2% and high grade 3.5%. The age ranged from 10 to 75 years and M: F ratio was 1.07:1. 38.8% (33/85) cases showed bone marrow involvement. Majority of bone marrow involvement was seen in indolent lymphomas (87.8%). Most common pattern of involvement was mixed (12/33) followed by diffuse (9/33), interstitial (8/33) and nodular (4/33). 87.9% cases showed increase in reticulin which included reticulin grade 1(9/33), grade 2(14/33) and grade 3(6/33). Only 48.5% cases of bone marrow involved cases had CBC abnormalities while 51.5% were completely normal. CBC abnormalities included anemia (5/16), leucopenia (3/16), leukocytosis (8/16) and thrombocytopenia (9/16).&#13;
Discussion: In the present study, bone marrow involvement by non-Hodgkin lymphoma was seen in 38.8% cases. Other studies also described the incidence of bone marrow involvement from 27.6% to 53%. Predominant involvement was observed in indolent cases which were similarly noted in other studies.&#13;
Conclusion: Bone marrow biopsy is an essential part of staging work up of NHL affecting the prognosis and treatment.&#13;
</p></abstract><kwd-group><kwd>Non Hodgkin lymphoma</kwd><kwd> Bone marrow infiltration</kwd><kwd> Hemogram</kwd></kwd-group></article-meta></front></article>
