Background: According to various studies psychiatric morbidities in post Myocardial Infarction (MI) patients increases the morbidity and mortality. Prevalence of psychiatric morbidities is important for to early intervention and to improve the quality of life. There is a paucity of research on Indian subjects and specially those of this area of south Rajasthan. Aim: To find out the prevalence of Depression and Anxiety following first attack of acute Myocardial Infarction. Method: 60 cases with an established diagnosis of first episode of acute MI were assessed in cardiac OPD by a cardiologist during follow up, after 2-3 months of attack and they were compared with 60 healthy controls. Results: 40% myocardial infarction patients were found to be suffering from depressive episode, 35% from anxiety symptoms and 16.6% from mixed anxiety and depressive symptoms. Severity of Depression and Anxiety also measured and findings were significantly associated with MI patients as compared to healthy controls. Conclusion: The high proportion of patients with MI found to be suffering from symptoms of depression and/ or anxiety two to three months after MI highlights the essential need to assess these symptoms in all such patients during the post - MI period as they merit appropriate treatment along with that of MI.