Transfusion of blood and blood products such as Whole Blood, Red Cell Concentrate, Platelet Concentrate, and Fresh Frozen Plasma play an important role in treating hospitalised patients. The irrational use of medical technology is a major factor in increased healthcare expenses. We have done a crossectional studyto estimate the appropriate usage of blood and blood products transfusions in P.D.U. Medical College and Hospital, Rajkot,Gujarat,(India). Methodology: We analysed 1050 blood and blood products requests for transfusion. A total of 1078 blood and blood products transfusions were evaluated in these patients. A review of the patients medical record was done on each request for blood and blood products for examplediagnosis, indication for transfusion, number of units requested and the speciality prescribing it. Overall prevalence of appropriate use of blood and blood products was assessed according to NACO (National AIDS Control Organization) guidelines. Results: A total of 1050 requests were received for blood and blood products transfusion from various departments .These patients received 1078 transfusions.Maximum number of blood transfusion requests were received from Obstetrics and Gynecology department. Maximumnumber of transfusions were done in Medicine department. Out of these total transfusions, Red Cell Concentrates were maximum. According to our study maximum inappropriate transfusions were of Red Cell Concentrates.Total prevalence of appropriate use of blood and blood products was 81%. Conclusion: There is a need for continuous auditabout the use of blood and blood products as therapy. This helps in reduction of prevalence of inappropriate use of blood products, thus thereby reduces the expenditure on health care.