Oral candidiasis is a general opportunistic infection of the oral cavity caused by an over growth of Candida genus,the most common being Candida albicans.The prevalence varies depending on certain predisposing factors and age.There are three extensive groupings consisting of acute candidiasis, chronic candidiasis, angularcheilitis.Risk factors comprise impaired salivary gland function,drugs, dentures, high carbohydrate diet, and extremes of life, smoking, diabetes mellitus, Cushing__ampersandsign#39;s syndrome and immunosuppressive conditions.Fluconazole oral suspension as a systemic therapy was used to treat oral candidiasis in HIV-infected patients and provided a longer disease-free interval before relapse