Objective: To compare the efficacy of honey phonophoresis versus low intensity laser therapy in female genital herpes simplex II. Research Methodology: Forty female patients suffering from genital herpes simplex type II assigned randomly into 2 groups; honey phonophoresis group (A) and low intensity laser group (B). Intensity of pain and serological response were recorded before and after 3 weeks of treatment. Results: The results of study showed that there were significant differences between both groups post-treatment as p value__ampersandsignlt; 0.05. Percentage of improvement in VAS, IgG, IgM after intervention were 60%, 45%, 8%, respectively for group (A ) while for group (B) were 82%, 66%, 56%, Respectively. Conclusion: The study concluded that low intensity laser was more effective than Honey phonophoresis in the treatment of genital herpes type II.