Background and Objectives: In chronic anemia the heart has to entertain a hyperdynamic circulation in order to compensate for reduced oxygen carrying capacity of blood. Chronic alterations of cardiac workload results in changes of LV geometry. The diagnosis of left ventricular hypertrophy (LVH) based on LV mass has been incorporated in the clinical practice as an important marker of CVD. Hence, present study was undertaken with the objective of estimating the LV mass in pts with chronic severe anemia and comparing with controls. Methodology: Present study was conducted in Al-Ameen Medical College and District Hospital, Bijapur. 31 anemic patients (aged 18-40 yrs) with Hb ? 7 gm% and equal no. of age and gender matched normal subjects were selected. All anemic patients and controls were subjected for hemoglobin estimation and M mode 2D Echocardiography. Echocardiographic parameters IVSTd, LVPWd, LVIDd were studied, LVM and LVMI were derived. Statistics-by Student__ampersandsignrsquo;s unpaired__ampersandsignlsquo;t__ampersandsignrsquo; test, correlation analysis. Results: Our study demonstrated increased LVM and LVMI in anemic patients compared to controls. Both correlated negatively with Hb levels. Interpretation and Conclusion: Left ventricular mass is an independent risk factor for prediction of cardiovascular events.Echocardiography is a simple, noninvasive imaging method in the evaluation of cardiac morphology and dynamics, hence can be used to evaluate LVM in chronic anemia. The findings of increased LVM and LVMI in anemic patients of our study are indicative of LV hypertrophy. Hypertrophy of cardiac myocytes occurs to meet the demand of increased rate of use of mechanical energy in response to sustained Hemodynamic overloading of the heart.