Aim: There are only few cases presented with Amlodipine-induced gingival enlargement so far. The main purpose of this case report is to discuss about Amlodipine-influenced gingival enlargement in a 56 years old female hypertensive patient and its periodontal management and maintenance. Case Report: In this case report, patient with a history of hypertension for past 2 years and presenting with Amlodipine-induced gingival enlargement and various approaches to manage it were discussed. Discussion: One of the common clinical features of gingival disease is gingival enlargement, otherwise termed as Gingival Overgrowth. Gingival enlargement occurs as a side effect following the administration of certain drugs. The most common drugs causing gingival enlargement are Anticonvulsants for eg Phenytoin, immuno-suppressants like Cyclosporine and calcium channel blockers (Nifedipine). Amlodipine - a third-generation calcium channel blocker is found to be associated with Gingival overgrowth even when prescribed in a very low dose of about 5mg. Conclusion: The results of this case report suggested that the combined non-surgical and surgical therapy resulted in complete healing of the gingival overgrowth with less post-operative complication.