Background: Various authors have studied the effect of thyroid hormones to estimate the male factor in infertility. Some have concluded that thyroid hormones have a role to play in determining the quality of sperms and some state that the hormones do not have any effect on spermatogenesis. This study was done to observe the effect of thyroid hormones in the affected males. Materials and Methods: The male partners of 71 infertile couples participated in the study. Semen analysis was done in the affected males after an abstinence of three days. Thyroid hormones estimation and semen analysis was done on the same day. The males were grouped as Oligospermic, severe Oligospermic and Azoospermic after semen analysis. Normospermic males were used as a control group. Result: The age range of the affected males was 24 __ampersandsignndash; 53 years. The mean years of marital duration were 7.7 years. The thyroid hormonal level was within normal limits in all the 71 males investigated. In semen analysis, 17 males were Normospermic. 22 males were Oligospermic, 22 were severe Oligospermic and 10 were Azoospermic. The mean sperm count was 9.18 million/ ml in Oligospermic, 3.3 million/ml in severely Oligospermic, Nil in Azoospermic and 123.86 million/ml in Normospermic males. Conclusion: Thyroid hormones do not have any effect on spermatogenesis in males.