Background: Tai Chi postures have recently been shown in a number of randomized controlled trials to improve balance and posture in a variety of patient groups. Balance and mobility are problems commonly encountered by people with Multiple Sclerosis (MS). This pilot study examines the effect of Tai-Chi __ampersandsignplusmn; Mental practise on balance, gait and mobility in people with MS. Objective: To determine the efficacy of both protocols in inducing balance and mobility improvements. Methods: About 25 volunteer MS patients were screened with Movement Imagery Questionnaire__ampersandsignmdash;Revised second version (MIQ-RS), Modified clinical test of sensory organisation and balance (mCTSIB) and Expanded Disability Status Scale (EDSS) before being included in this study. 16 people satisfying the inclusion criteria with Relapsing Remitting MS (RRMS) were randomly assigned to either a Tai Chi group or to Tai chi with mental practise group. The first group participated in 20 sessions of total 60 minutes duration (20 minutes mental practise followed by 40 minutes tai-Chi), for 10-12 weeks The second group participated in 20 sessions which were 40 minutes long for 10-12 weeks. Out of all the known forms of Tai-Chi forms, six wereselected an d practised during these sessions. Results: There was no significant difference between group 1and group 2 for age, gender, MS duration, MIQ score, mCTISB and EDSS. Both the groups showed significant improvement (p__ampersandsignlt;0.05)post respective therapies. The percentage improvement__ampersandsignnbsp;post intervention in both the groups was comparable. Even though Group 1 performed better than Group 2 across most tests, the difference were not significant and consistent. Conclusions: Both the treatment protocols improve the balance and mobility of the RRMS patients and Tai Chi intervention showed considerable improvement in test scores. The impact of mental practice was not statistically significant across all tests. However, patients who were allotted to this group showed better comprehension of Tai Chi forms and higher retention rate.__ampersandsignnbsp;