Arthritis is one of the commonest joint disorder affecting millions of people worldwide with an estimated 15% (40 million) of Americans had some form of arthritis in 1995 and by the year 2020, an estimated 59.4 million will be affected. In India it affects 15% (180 million) people. Ancient Unani scholars have elaborately described inflammation and pain of joints under the caption of Waja ul Mafasil and managed with multidimensional approach, in contrast with the present day management of disease mainly with non-steroidal anti-inflammatory drugs (NSAIDs) which will be having large number of adverse effects. This review article highlight the salient features describing arthritis with reference to Waja ul Mafasil for empathizing disease condition as enunciated by Unani scholars to provide a better alternative in terms of cost effective managements and side effects.