Introduction: Profunda femoris artery is the largest branch of femoral artery. It is frequently incorporated in vascular reconstructive procedures in the proximal leg. Objectives: This study is aimed at observing the site of origin of profunda femoris artery, measuring the distance between midinguinal point (MIP) and the site of origin of profunda femoris artery (PFA) and studying the variations of its branches. Materials and methods: This study was performed on one hundred and three lower limbs of properly embalmed cadavers.Results: We found that the mean distance between MIP and the site of origin of PFA was 4.3 __ampersandsignplusmn; 1.13 cm on the right side and on__ampersandsignnbsp;the left side it was 4.3 __ampersandsignplusmn; 1.08 cm. We also found that there was a high origin of PFA in 3 cases (5.8%) on the right side and in 4 cases (7.8%) on the left side. In two lower limbs, there was bilateral higher origin of PFA. The lateral circumflex femoral artery (LCFA) was arising from the femoral artery in 9.6% of right lower limbs and 2% of left lower limbs. The medial circumflex femoral artery (MCFA) was arising from the femoral artery in 3.9% of the left lower limbs. Conclusion: The anatomical knowledge of location of PFA and variations of its branches i.e. medial and lateral circumflex femoral arteries is important to avoid inadvertent damage to these vessels and to avoid complications during surgeries.