Background: Frozen shoulder, one of the leading causes of shoulder pain with incidence of 2% in India is frequently treated by physiotherapist. Very few studies have emphasized combination of modalities or comparison of combined treatments for frozen shoulder till date. Thus, there is a need to evaluate the effectiveness of combined treatments for better implications in clinical practice. This study was aimed at comparing the efficacy of end range mobilization (ERM) and interferential current therapy (IFT) with moist heat and stretching on pain, range of motions and disability of shoulder in acute stage of frozen shoulder. Methodology: This clinical trial includes 43 subjects in the acute stage of frozen shoulder with SPADI score __ampersandsigngt; 30. Group 1 (n=22) received treatment including moist heat application and shoulder stretching exercises whereas group 2 (n=21) received end range mobilisation with interferential current therapy. Follow up was taken at 6th day of treatment using SPADI, ROM and VAS for pain. Results: Between Group comparison showed no statistically significant improvement (p=0.41) on VAS Score. However, Abduction (p=0.006), Flexion (p=0.03), and Internal Rotation (p=0.03) were statistically and clinically significant in group 2. Improvement was not observed for external rotation (p=0.8) and SPADI scale (p=0.57). Conclusion: The results demonstrated that the end range mobilization can be used for better improvement in ROM in acute stage of frozen shoulder. Both the treatment strategies can be equally useful for pain management.