Background: Identifying etiology and co-morbid conditions of SOL liver is important for further management. Objectives: To evaluate the different causes of Space Occupying Lesion (SOL) of liver and find out etiology of liver tumor among patients of SOL of liver and also short term follow up of treatable condition. Method: Observational study is done over 1 year on 40 patients aged above 12 years with SOL liver who has attended General Medicine outdoor and/or indoor of NRS Medical College and Hospital. Longitudinal type of prospective study techniques have been used to analyses data. Results: The study shows that the highest percentage (27.5) of SOL seen in 51-60 years of age group and male were affected more than females (70% and 30% respectively). Metastatic adeno carcinoma was the commonest cause of liver SOL (32.55) followed by amoebic and pyogenic liver abscess (20% and 15% respectively). On 6 months follow up there was 83.33% complete resolution of pyogenic abscesses and 37.5% complete resolution of amoebic liver abscesses. Conclusion: Majority of liver SOL are metastatic adenocarcinoma. Next common SOL is amoebic liver abscess, followed by pyogenic liver abscess. Majority of liver abscesses responded with antibiotics.