Context: Several arthroscopic portals are used for arthroscopy for which understanding of anatomy of ankle and foot is very important. Aims: To study the anatomy of ankle joint in relation to the anterior, posterior and medial midline arthroscopic portals by dissection method. Methods and Material: The distance of the portals to the corresponding neurovascular structures was measured in 20 cadavers using a vernier caliper. Results: The mean distance between the anteromedial portal and the great saphenous vein and saphenous nerve was found to be 7.7 mm, that between the medial midline portal and the dorsalis pedis artery and deep peroneal nerve was found to be 1.7 mm. The mean distance between the anterocentral portal and the dorsalis pedis artery and deep peroneal nerve was found to be 1.4 mm, and that between the anterolateral portal and superficial peroneal nerve was found to be 2.5 mm. Absence of peroneus tertius was found in 2 out of 20 cases. The mean distance between posterolateral portal and sural nerve was found to be 15.9 mm. Conclusions: The present study confirmed that use of anteromedial portal for ankle arthroscopy is comparatively safe while indicating high chances of injury to dorsalis pedis artery and deep peroneal nerve in both anterocentral and middle midline portals. In case of anterolateral portal the study found the mean distance to be 2.5mm but variations in distribution of superficial peroneal nerve and in tendons of this region have to be studied beforehand to avoid injury to the nerve.