An operative management of complex physiochemical properties of drugs is vital for their effective cellular uptake and action. During the last decade, the complexity of drugs addressed in the state-of-the-art therapeutics has increased along with the computational capability to generate more and more detailed information from the structure activity relationships. With the development of drug delivery carrier, particularly polymer carriers, targeted release of drugs have reached new levels. Whilst slower than other architectures - like hydrogels - at the beginning of the new generation cargo molecules, silver nanoparticle (AgNPs) incorporated drug carriers have now reached new levels in both amelioration of toxicity and in enhancing stability and solubility of drugs. These progresses allow AgNPs integrated systems to generate output which are competent with the ones obtained from the cutting-edge polymer carriers, while keeping the benefits of conserved action at varying physiological conditions.