Introduction: Diabetic Retinopathy (DR), one of the leading cause of visual impairment in adults, a kind of serious microvascular complication of Diabetes Mellitus. It is well known that purine metabolites are strongly associated with the development of diabetic microvascular complications. Uric acid, an end product of the purine metabolism, acts as a pro-oxidant and it may thus be a marker of oxidative stress. Objectives: 1. To Estimate and Compare Anthropometric and Biochemical parameters in Diabetic Retinopathy patients, Diabetes without Retinopathy and clinically proven healthy controls. 2. To correlate Serum Uric acid levels with Anthropometric and Biochemical indices in Diabetic Retinopathy patients. Materials and Methods: Study group consisted total of 150 subjects divided into three groups- Group I (Clinically proven healthy controls), Group II (Type 2 Diabetes Mellitus without retinopathy) and Group III (Diabetic retinopathy), visiting RL Jalappa hospital and Research centre Kolar. Anthropometric __ampersandsignamp; Biochemical parameters were estimated by standard methods. Results: Comparison of Anthropometric __ampersandsignamp; Biochemical parameters were done among the three Groups, we observed Age, Obesity index, Fasting Blood Sugar, HbA1c, Total Cholesterol, high density lipoproteins, low density lipoproteins __ampersandsignamp; Uric acid were statistically significant with p value __ampersandsignlt;0.05 and also positive correlation was observed for Body mass index,Fasting Insulin, Total Cholesterol, high density lipoproteins and low density lipoproteins with Uric Acid in Group III. Conclusion: Hyperglycemia and Oxidative stress in Type 2 Diabetes Mellitus leads to micro and macrovascular complications. In Group III, there was positive correlation of serum Uric Acid with Anthropometric __ampersandsignamp; Biochemical Indices. Therefore uric acid can be considered as a reliable marker which is less expensive and helps clinicians in controlling the progression of DM to microvascular complications like DR.