In our present case, we observed a variation in branching pattern of the thoraco-acromial artery which in turn is a branch of second part of axillary artery. Normally the thoraco-acromial artery arises as a single trunk giving rise to four branches. In the present case the thoraco-acromial artery was absent. The clavipectoral trunk and deltoacromial trunk arose directly from axillary artery. The clavipectoral trunk divided into clavicular and pectoral branch whereas the deltoacromial trunk divided into deltoid and acromial branch, the course and termination of branches were normal. The present variation was observed in right axillary artery of a male cadaver during routine dissection of undergraduate students, in Bidar institute of medical sciences, Bidar. There was no variation in the branching pattern of thoraco-acromial artery of second part of left axillary artery. The knowledge of such variation is of important for surgeons while performing cannulation of axillary artery for various procedures and also for orthopaedicians while reducing dislocations of shoulder and correction of fractures of upper end of humerus.