Visfatin is a newly discovered member of adipokine family. It is a visceral adipokine, it has been found in skeletal muscle, liver, bone marrow and lymph. It was originally identified as a cytokine-like secreted protein that synergizes the effect of IL-7 and stem cell factor in promoting the growth and differentiation of B-cell lineage precursors. It is expressed in lymphocytes of peripheral blood and plays a role in lymphocytes maturation and inhibition of neutrophil apoptosis. It is an endocrine, autocrine as well as paracrine protein with many functions including enhancement of cell proliferation, biosynthesis of nicotinamide mono- and dinucleotide and induction of hypoglycemia. Visfatin has been shown to exert insulin mimetic and pro-inflammatory effects, One of the fundamental functions of visfatin is the modulation of immune and inflammatory processes. It has been reported that visfatin activated nuclear factor-kappa B which has a crucial role in regulating immune responses. Up-regulation of visfatin has been also identified in a variety of pathophysiological conditions of the immune system including rheumatoid arthritis, psoriasis, clinical sepsis and acute lung injury. Recently, there has been mounting body of studies investigating the association of visfatin with periodontal disease. This article gives an insight about visfatin and its correlation with periodontal disease.