Introduction: With the widespread use of automated cell counters, clinicians in any field of medicine may encounter thrombocytopenia. The symptomatology of thrombocytopenia varies greatly and the underlying cause may be either inconsequential (pseudo-thrombocytopenia) or life threatening. Aims and Objectives: To evaluate different causes of thrombocytopenia along with study of clinical profile and laboratory parameters in patients with thrombocytopenia. Materials and Method: A total of 100 patients with thrombocytopenia admitted to Civil Hospital, Ahmedabad and were evaluated. Patients with platelet count __ampersandsignlt;1 lack/mm3 were included in study whereas patients with malignancy and chemotherapy induced thrombocytopenia were excluded. Results: The present study includes age group 13-70 years. The highest incidence of thrombocytopenia belonged to the age group 21-30 years (30%) followed by 13-20 years (24%) and 31-40 years (22%).The diseases that causes thrombocytopenia commonly like Megaloblastic anemia and infections (malaria, dengue, enteric fever, and septicemia) are common in younger population. Our study shows almost __ampersandsignfrac34; of total patients were below age of 40 years. Conclusion: Bleeding manifestations were present in 1/3rd of patients and the common site is skin and mucous membrane in 1/3rd patients the main cause of which was ITP and majority patients had platelet count __ampersandsignlt;20,000/__ampersandsignmu;l.