Aims: The present study is done to study the frequency, morphology and to find out the etiology of granulomatous lesions by clinicopathologic correlation wherever possible. Materials and methods: A retrospective analysis of 75 biopsy sections was done from August 2010 __ampersandsignndash; July 2014. Diagnosis was confirmed by haematoxylin and eosine stained slides alongwith the special stains wherever required. Results: A total of 75 cases of granulomatous lesions were identified of which 42(56.0%) were malesand 33(44.0%) were females. Granulomas due to tuberculosis accounted for the majority of the types of granulomas,i.e,46 cases(61.33%), followed by 7 (9.33%)cases of foreign body granulomas, 5 (6.67%) fungal granulomas, 4 (5.33%) actinomycosis, granulomas of unknown etiology were - 4(5.33%) cases of granulomatous synovitis, 1(1.33%) cases of granulomatous cystitis and 5 (6.67%) cases of non infectious skin granulomas. The granulomatous skin lesions reported were mostly infectious __ampersandsignndash;3(4.0%) leprosy, 2 (2.67%) lupus vulgaris, 3(4.0%)cases of actinomycosis, 1(1.33%) scrofuloderma, and fungal granulomas __ampersandsignndash; 2(2.67%) subcutaneous phaeohyphomycosis 1(1.33%) maduramycosis, 1(1.33%) chromoblastomycosis, 1(1.33%)zygomycosis; 5(6.67%)non infectious skin granulomas reported as granuloma annulare, erythema nodosum and acne agmeneta. Granulomatous lesions of the genitourinary tract constituted 8(10.67%) cases __ampersandsignndash; 3 (4.0%) tuberculosis of cervix and fallopian tube, 4 (5.33%) tuberculousepididymoorchitis and scrotal abscess; 1 (1.33%) granulomatous cystitis. Tuberculous lesions affecting the gastrointestinal tract were __ampersandsignndash; 3(4.0%)cases of fistula in ano, 1(1.33%) appendicular tuberculosis and 1(1.33%) case rectum.1(1.33%) case each of tuberculosis of spine and actinomycosis of tonsil was reported. AFB stain was positive in 14 (30.43%) cases of tuberculosis. Conclusion: Tuberculosis was the commonest cause of granulomatous lesion and lymph nodes were the most common site affected. Epithelioid type of granuloma was the most common morphology.