Background and Objectives: Malaria and Hepatitis B Virus (HBV) infections are co-endemic throughout much of the tropical and Sub-Saharan Africa and both present major threat to public health. Nigeria is endemic for both Malaria and Hepatitis B virus infections. Presence of both infections concurrently in an individual might have significant clinical and public health implications. Hence the present study was undertaken to detect the prevalence of Hepatitis B-Malaria co-infections in a tertiary health center in Northwestern Nigeria. Methodology: The study was carried out on 200 patients presenting with fever to the General Outpatient Department (GOPD) of the Murtala Muhammed Specialist Hospital (MMSH) Kano using Gold Standard microscopy and rapid diagnostic test (RDT). Results: Fifty one (25.5%) out of the total subjects studied were malaria positive. Females presented with higher rate of malaria infection with 18% prevalence than males with 7.5%. Age group 15-24 had the highest malaria prevalence (11%), followed by age group 25-34 with 6.5%. Thirteen (6.5%) subjects were HBsAg positive. Males had higher rate of infection with 4.5% prevalence than females with 2.0%. Nine individuals representing 4.5% of the total population had co-infection with higher prevalence observed among the males with 3.0%. Age groups 25-34 were observed to have high co-infection rate of 1.5% and the least prevalence was observed among the age group 15-24 with 0.5% prevalence for both males and females. Conclusion: These findings ware discussed in the light of the prevalence of co-infection with the two ailments and showed a decreasing trend of the infections.