Background: Atherosclerosis is one of the major causes of morbidity and mortality worldwide. Autopsy study is a gold standard for atherosclerosis. None of the study done on autopsy to prove the carotid atherosclerosis has the generalized nature. Objective: To examine the association between carotid atherosclerosis with coronary, aorta and renal arteries in non cardiac patients using histological analysis. Methods: We histologically examined 91 patients died of non cardiac cause. Atherosclerotic lesion in carotid, coronary, aorta and renal arteries were noted and graded according to modified AHA classification of atherosclerosis using morphological descriptions (2000). Results: Mean of carotid atherosclerosis was 11.5__ampersandsignplusmn;0.71, in coronary it was 37.33__ampersandsignplusmn;7.57, in aorta the mean we found was 27__ampersandsignplusmn;9. The mean of renal artery atherosclerosis was 2.75__ampersandsignplusmn;0.71. The association of carotid atherosclerosis with coronary, aorta and renal arteries was statistically significant (p __ampersandsignlt; 0.05). Conclusion: In present study we conclude that if carotid atherosclerosis is present, patient will be having coronary, aortic atherosclerosis but patient might have renal atherosclerosis. If carotid atherosclerosis is absent it doesn__ampersandsignrsquo;t mean that patient won__ampersandsignrsquo;t be having atherosclerosis in any other vessels.