Objective: To detect association of serum lipid profile, uric acid and body mass index in preeclampsia and to measure their clinical significance. Methods: A prospective case-control study was conducted at Kamineni Institute of Medical Sciences, Narketpally. One hundered patients with pre-eclampsia were compared with age matched 100 normotensive pregnant woman. Body mass index was calculated. Blood pressure was measured. Their serum levels of triglycerides (TG), Cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) and serum uric acid were measured. Data was analysed by students t-test and Chi?square test. Results: Blood pressure, body mass index ,TG, VLDL, LDL, cholesterol and serum uric acid level were significantly higher in preeclamptic women (p__ampersandsignlt;0.05); while serum HDL was significantly low in preeclamptic women (p__ampersandsignlt;0.05). Conclusion: Lipid abnormalities, mostly elevated TG, cholesterol, LDL, VLDL, maternal obesity and uric acid are associated with preeclampsia. Early detection of these parameters may help in their better management.