Introduction: Post-operative visual status after successful penetrating keratoplasty depends mainly on the clarity of the graft and the refractive error, particularly the astigmatic component. Severe irregular astigmatism is often seen after keratoplasty which can delay visual rehabilitation, even with a clear graft. Aim: The aim of this study was to co-relate post- keratoplasty astigmatism by using different number of sutures and different donor graft sizes. Material and Method: In this prospective study, 80 eyes of patients underwent penetrating keratoplasty with interuppted suturing techniques with different numbers of sutures and by using different size of donor graft size. Conclusion: Post operative corneal irregular astigmatism was noted to be more common with increased number of sutures and large donor graft size.